Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

Somatic cells can accumulate structural variations such as deletions. Here, Møller et al. show that normal human cells generate large extrachromosomal circular DNAs (eccDNAs), most likely the products of excised DNA, that can be transcriptionally active and, thus, may have phenotypic consequences

Results of differential expression analysis for the manuscript "N-of-one differential gene expression without control samples using a deep generative model"

<p>Output files for the differential gene expression analysis in the manuscript "N-of-one differential gene expression without control samples using a deep generative model".  The zip file contains three folders with the results for DESeq2 and the DGD (named NB-GMM in the folders).</p><p>- The folder  False_positives_Fig4B contains the results presented in figure 4B of the manuscript. The file False_positive_single_vs_all.csv contains the results for the one-vs-all experiments. The file False_positive_5_vs_all.csv contains the results for the 5-vs-all experiments.</p><p>- The folder enrichment_plots contains the results presented in figure 4C of the manuscript. Each subfolder (e.g. Basal, HER2E, LumA, LumB) contain the differential expression analysis results for each breast cancer subtype.</p><p>- The folder fig5 contains the results presented in figure 5 of the manuscript. The results for each cancer are presented in a folder.</p&gt