Synthesis and antimicrobial activity of carboxylate phosphabetaines derivatives with alkyl chains of various lengths

The purpose of the present study was to investigate the antibacterial activity of fifteen novel nanosized alkyl esters of carboxylate phosphabetaine: β-(carboxyalkyl)ethyltriphenylphosphonium bromides 4-8, β-(carboxyalkyl)-β-methylethyltriphenylphosphonium bromides 9-13, and β-(carboxyalkyl)-α-methylethyltriphenylphosphonium bromides 14-18. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive and gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate that the synthesized phosphonium salts 4-18 possess a broad spectrum of activity against the tested microorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, and 31P NMR spectral studies. © 2013 Irina V. Galkina et al

Synthesis and antimicrobial activity of bis-4,6-sulfonamidated 5,7-dinitrobenzofuroxans

A new series of bis-4,6-sulfonamidated 5,7-dinitrbenzofuroxans 7-11 had been synthesized and tested for antimicrobial activity. The structures of new sulfanilamide derivatives were characterized by elemental analysis, IR spectroscopy, and mass spectrometry (MALDITOF). The synthesized compounds were tested for their in vitro antimicrobial activity using the disk diffusion method against Gram-positive bacteria Staphylococcus aureus; the Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis; the fungal strain Aspergillus niger; and the yeast-like pathogenic fungus Candida albicans. Our results indicate that the compounds 7-11 exhibit potent antimicrobial activity. The stability of the compounds was evaluated by TG and DSC methods. © 2014 Irina V. Galkina et al

Synthesis and biological evaluation of novel carboxylate phosphabetaines derivatives with long alkyl chains

© 2016 Taylor & Francis Group, LLC.The purpose of the present study was to investigate the antibacterial activity of novel alkyl esters of carboxylate phosphabetaine: β-(carboxyalkyl)ethyltributylphosphonium bromides 4–8. The in vitro microbiological activity of the synthesized phosphonium bromides against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. Microbiological results indicate the synthesized phosphonium salts possess a broad spectrum of activity against the testedmicroorganisms. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, 31P NMR spectral studies

Synthesis, structure, and antibacterial activity of aminobenzofuroxan and aminobenzofurazan

The amination of 4,6-dichloro-5,7-dinitrobenzofuroxan and 4,6-dichloro-5,7-dinitrobenzofurazan with dibenzylamine followed the aromatic nucleophilic substitution pattern (SNAr) and gave products of replacement of both chlorine atoms in the six-membered ring with elimination of hydrogen chloride. Regardless of the reactant ratio, 4,6-dichloro-5,7- dinitrobenzofuroxan was converted into 4,6-bis(dibenzylamino)-5,7- dinitrobenzofuroxan, whereas 4,6-dichloro-5,7-dinitrobenzofurazan under analogous conditions gave rise to unusual bisammonium derivative which lost proton from the amino group on C4 and benzyl group from the amino group on C6; as a result, the corresponding diamine with secondary and tertiary nitrogen atoms was obtained. The structure of the isolated compounds was determined by IR and NMR spectroscopy, elemental analysis, and X-ray analysis; their thermal stability was studied by simultaneous thermogravimetry and differential scanning calorimetry. © 2013 Pleiades Publishing, Ltd

Synthesis and structure of novel phosphorylated azomethines

© 2016 Taylor & Francis Group, LLC.The condensation of do-, hexa-, octadecan-1-amines with bromo- and nitrobenzaldehydes yielded a series of Schiff bases in good yields. Subsequent reaction of these compounds with dioctylphosphine oxide yielded phosphorylated azomethines and some were characterized using X-ray crystallography. The structure of the isolated compounds was determined by IR and NMR spectroscopy, elemental analysis, and their thermal stability was studied by simultaneous thermogravimetry and differential scanning calorimetry. All of the synthesized compounds were tested for their antibacterial and anti-Candida activity. A number of the compounds exhibited antimicrobial activity comparable to that of the commercially available drugs, ciprofloxacin and clotrimazole

Tumor Necrosis Factor-mediated survival of CD169⁺ cells promotes immune activation during vesicular stomatitis virus infection

Innate immune activation is essential to mount an effective antiviral response and to prime adaptive immunity. Although a crucial role of CD169+ cells during vesicular stomatitis virus (VSV) infections is increasingly recognized, factors regulating CD169+ cells during viral infections remain unclear. Here, we show that tumor necrosis factor is produced by CD11b+ Ly6C+ Ly6G+ cells following infection with VSV. The absence of TNF or TNF receptor 1 (TNFR1) resulted in reduced numbers of CD169+ cells and in reduced type I interferon (IFN-I) production during VSV infection, with a severe disease outcome. Specifically, TNF triggered RelA translocation into the nuclei of CD169+ cells; this translocation was inhibited when the paracaspase MALT-1 was absent. Consequently, MALT1 deficiency resulted in reduced VSV replication, defective innate immune activation, and development of severe disease. These findings indicate that TNF mediates the maintenance of CD169+ cells and innate and adaptive immune activation during VSV infection