Alteration and vein mineralisation within the Lizard complex, south Cornwall: Constraints on the timing of serpentinisation.

Two distinct episodes of serpentinisation have been identified within the peridotites of the Lizard complex. The first episode (primary serpentinisation) is represented by the complex and pervasive hydration of the Lizard peridotite. The second (later) episode is characterised by a pale to dark green, pseudo-fibrous mixture of lizardite and chrysotile that is restricted to fractures (vein serpentine). Mineralised north-north-west and east-north-east trending fault zones contain fragments of vein serpentine generated during this second episode. Faults with similar orientations and mineralogy within the gabbro unit contain adularia which have been previously elated by Ar-10-Ar-39 and K-Ar methods at 210-220 Ma (Triassic). Stable isotope ratios indicate that the mineralisation within the gabbro and peridotite is genetically similar. The primary and secondary serpentinisation episodes are therefore interpreted as pre-Triassic in age. A latest Carboniferous to early Permian age is proposed for the formation of vein serpentine and a late Devonian to Carboniferous age is proposed for the primary serpentinisation episode. This is envisaged to have taken place post-obduction but a pre-obduction initiation of serpentinisation cannot be discounted

A re-interpretation of the internal structure of the Lizard complex ophiolite, south Cornwall.

publication-status: PublishedPrevious models for the tectonic-stratigraphy of the Lizard complex ophiolite have proposed three thrust-bounded units. However, our studies indicate that post-obduction extensional faulting may have exerted a hitherto unrecognised effect on the present distribution of lithologies. Field and previously published geophysical evidence suggest that the uppermost tectonic unit (the Crousa Downs Unit) represents the downfaulted upper levels of the Goonhilly Downs Unit. Deformed lithologies previously thought to be part of the Goonhilly Downs Unit are reassigned to the underlying Basal Unit. A revised model for the tectonic-stratigraphy is presented. The Basal Nappe is underlain by the Basal Thrust and comprises the Traboe schists, the Landewednack schists and the Old Lizard Head Series. The Goonhilly Downs Nappe, underlain by the Goonhilly Downs Thrust, structurally overlies the Basal Nappe and comprises serpentinised peridotite, Trelan and Crousa Gabbro and the Porthoustock Sheeted Dyke Complex. This work highlights the importance of late- to post-Variscan extensional deformation in south Cornwall

Early Jurassic palaeoenvironments in the Surat Basin, Australia - marine incursion into eastern Gondwana

Interpretations of palaeodepositional environments are important for reconstructing Earth history. Only a few maps showing the Jurassic depositional environments in eastern Australia currently exist. Consequently, a detailed understanding of the setting of Australia in Gondwana is lacking. Core, wireline logs, two‐dimensional and three‐dimensional seismic from the Precipice Sandstone and Evergreen Formation in the Surat Basin have been used to construct maps showing the evolution of depositional environments through the Early Jurassic. The results indicate the succession consists of three third‐order sequences (Sequence 1 to Sequence 3) that were controlled by eustatic sea level. The lowstand systems tract in Sequence 1 comprises braidplain deposits, confined to a fairway that parallels the basin centre. The strata were initially deposited in two sub‐basins, with rivers flowing in different orientations in each sub‐basin. The transgressive systems tract of Sequence 1 to lowstand systems tract of Sequence 3 is dominated by fluvio–deltaic systems infilling a single merged basin centre. Finally, the transgressive and highstand systems tracts of Sequence 3 show nearshore environments depositing sediment into a shallow marine basin. In the youngest part of this interval, ironstone shoals are the most conspicuous facies, the thickness and number of which increase towards the north and east. This study interprets a corridor to the open ocean through the Clarence–Moreton Basin, or the Carpentaria and Papuan basins, evidence of which has been eroded. These results challenge a commonly held view that eastern Australia was not influenced by eustasy, and propose a more dynamic palaeogeographic setting comprising a mixture of fluvial, deltaic and shallow marine sedimentary environments. This work can be used to unravel the stratigraphic relationships between Mesozoic eastern Australian basins, or in other basins globally as an analogue for understanding the complex interplay of paralic depositional systems in data poor areas

Physical activity attenuates the influence of FTO variants on obesity risk: A meta-analysis of 218,166 adults and 19,268 children

Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268). Methods and Findings: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r2>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (pinteraction= 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. Concl

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Diversity of repC plasmid-replication sequences in Rhizobium leguminosarum

International audienc

Diversity of repC plasmid-replication sequences in Rhizobium leguminosarum

International audienc