Lessons Learned: The Bush Foundation Infant Toddler Development Program Turns 10

Describes a complex ten-year initiative to develop curricula and train faculty, state agencies, and the child care community in reducing barriers to the healthy development of young children in Minnesota, North Dakota, and South Dakota

Direct determination of absolute stereochemistry of α-methylselenocysteine using the Mosher method

Mosher amides of α-methylselenocysteine were synthesized to determine the absolute stereochemistry of the sterically hindered α-carbon utilizing 1H, 13C, 19F, and 77Se NMR spectroscopies. After analysis of these spectra using the established Mosher method, the stereochemistry of the α-carbon was determined to be (R), which was subsequently confirmed using x-ray crystallography

A potassium crown ether complex with dichloroaurate(I)

This is the published version, also available here: http://dx.doi.org/10.1107/S1600536803000813.The title compound, (1,4,7,10,13,16-hexaoxa­cyclo­octane)­potassium di­chloro­aurate(I), [K(C12H24O6)][AuCl2], consists of potassium ion encapsulated by the 18-membered crown ether 1,4,7,10,13,16-hexaoxa­cyclo­octane and a linear di­chloro­aurate(I) monoanion. The potassium occupies a crystallographic center of symmetry with a ring coordination number of six, and two chlorides in axial sites at a distance of 3.2306 (5) Å. The linear anionic species sits on another crystallographic center of symmetry

GREATER SKELETAL CONTRIBUTIONS TO LEG STIFFNESS IN HIGHCOMPARED TO LOW-ARCHED ATHLETES DURING RUNNING AND LANDING MOVEMENTS.

The contributions of skeletal and muscular structures to stiffness may underlie the distinct injury patterns observed in high- (HA) and low-arched (LA) athletes. This study compared skeletal and muscular contributions to leg stiffness in HA and LA athletes during running and landing. Ten HA and 10 LA female athletes performed five over ground running trials and five step off landing trials. Leg stiffness, and skeletal and muscular contributions to leg stiffness were calculated using Visual 3D and MatLab. HA athletes had greater leg stiffness (p=0.010) and skeletal stiffness (p=0.016) in running. During landing, HA had greater leg stiffness (p=0.015) and skeletal stiffness (p\u3c0.001) while LA athletes had greater muscular stiffness (p=0.025). These findings demonstrate that HA athletes place a greater reliance upon skeletal structures for load attenuation during running and landing which may underlie their distinct injury patterns

Evaluation of the Indiana Child Care Financing Initiative

A research report evaluating the results of the Indiana Child Care Financing Initiative, a statewide effort to improve child care in Indiana. The report summarizes results in the areas of improving capacity, quality, and community awareness of child care issues, as well as the role of 69 local projects in initiating or expanding local partnerships focused on child care

Charge-localized p-phenylenedihydrazine radical cations: ESR and optical studies of intramolecular electron transfer rates

1,4-Bis(2-tert-butyl-2,3-diazabicyclo[2.2.2]oct-3-yl)benzene-1,4-diyl (2) its 2,5-dimethyl and 2,3,5,6-tetramethyl derivatives (3 and 4), their radical cations, and bis-radical dications are studied. Crystal structures including those of 2^+BPh_4^-, 3^(2+)(BPh_4^-)_2, 4^+BPh_4^-, and 4^(2+)(BPh_4^-)_2 establish that ring methylation causes more N-lone pair, aryl π twist without changing the NAr,NAr distance significantly and that both 2^+ and 4^+ have the charge localized in one hydrazine unit. NMR measurements show that 3^+ has about 6% of its spin at the four aryl CH and CMe carbons, while 4^+ has about 1.5% of its spin at the four CMe carbons. The average distance between the unpaired electrons of 3^(2+) and 4^(2+) was obtained from the dipolar splittings of their thermally excited triplet states and, as expected, is significantly smaller for 3^(2+) (5.25 Å) than for 4^(2+) (5.63 Å). Rate constants for electron transfer between the hydrazine units of 3^+ and 4^+ in CH_2Cl_2 and CH_3CN were determined by dynamic ESR. The intervalence radical cations show charge transfer bands corresponding to vertical electron transfer between the ground state and the highly vibrationally excited electron-shifted state, allowing calculation of the parameters controlling electron transfer. Electron transfer parameters obtained from the CT bands using adiabatic energy surfaces which approximate the CT band shapes observed produce rate constants within experimental error of those extrapolated to room temperature from the ESR data for both 3^+ and 4^+ in both solvents, without using tunneling corrections. The effects of mixing of the electronic wave functions of the reduced and oxidized hydrazine units of 2^+ on d_(NN), the C(t-Bu)N,NA(Ar) twist angle, and the aryl nitrogen lone pair, aryl π twist angle which are observed by X-ray are close to those predicted from the position of the minima on the ET coordinate X of the adiabatic energy surface calculated from the CT band

(2,3,7,8,12,13,17,18-Octa­ethyl­por­phin­ato)(trifluoro­methane­sulfonato)iron(III)

The title compound, [Fe(CF3O3S)(C36H44N4)], is an iron(III) porphyrin complex with the trifluoro­methane­sulfonate anion as an axial ligand. The Fe atom is displaced by 0.219 (2) Å toward the trifluoro­methane­sulfonate anion from the 24-atom mean plane of the porphyrin, resulting in a distorted FeN4O square-based pyramidal geometry. One ethyl­ene group is disordered over two orientations in a 0.502 (6):0.498 (6) ratio

[5,10,15,20-Tetra­kis(4-meth­oxy­phen­yl)porphyrinato-κ4 N,N′,N′′,N′′′](trifluoro­methane­sulfonato-κO)­iron(III)

The title compound, [Fe(CF3O3S)(C48H36N4O4)], is a five-coordinate iron(III) porphyrin complex with a trifluoro­methane­sulfonate anion as an axial ligand. The FeIII atom is displaced by 0.40 (1) Å towards the trifluoro­methane­sulfonate anion from the 24-atom mean plane of the porphyrin. The average Fe—Np distance is 2.044 (2) Å and the Fe—O distance is 2.001 (2) Å

Dinitro­sylbis[tris­(4-chloro­phen­yl)phosphane]iron

The title dinitrosyl iron diphosphane complex, [Fe(NO)2(C18H12Cl3P)2] or Fe(NO)2 L 2 [L = P(C6H4-p-Cl)3] belongs to the family of metal dinitrosyl compounds with the general formula Fe(NO)2(L)x, referred to collectively as dinitrosyl iron compounds (DNICs). The iron atom is tetra­hedrally coordinated by two phosphane ligands and two NO groups with Fe—N—O bond angles of 178.76 (15) and 177.67 (14)°

Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water.

The selective detection of citrate anions is essential for various biological functions in living systems. A quantitative assessment of citrate is required for the diagnosis of various diseases in the human body; however, it is extremely challenging to develop efficient fluorescence and color-detecting molecular probes for sensing citrate in water. Herein, we report a macrocycle-based dinuclear foldamer (1) assembled with eosin Y (EY) that has been studied for anion binding by fluorescence and colorimetric techniques in water at neutral pH. Results from the fluorescence titrations reveal that the 1·EY ensemble strongly binds citrate anions, showing remarkable selectivity over a wide range of inorganic and carboxylate anions. The addition of citrate anions to the 1·EY adduct led to a large fluorescence enhancement, displaying a detectable color change under both visible and UV light in water up to 2 μmol. The biocompatibility of 1·EY as an intracellular carrier in a biological system was evaluated on primary human foreskin fibroblast (HF) cells, showing an excellent cell viability. The strong binding properties of the ensemble allow it to be used as a highly sensitive, detective probe for biologically relevant citrate anions in various applications