Isolation and characterization of homoisoflavonoids from Scilla persica HAUSSKN

Plantas medicinais apresentam muitas atribuições tradicionais, incluindo o tratamento de doenças de origem infecciosa. A pesquisa científica é extremamente importante na avaliação dos usos tradicionais. Neste estudo, cinco homoisoflavonóides: 3-(4'-hidroxibenzilideno)-5,7-diidroxi-6-metoxicroman-4-ona(autumnalina), 3-(4'-hidroxibenzil)-5,7-diidroxi-6- metoxicroman-4-ona (3,9-diidro-autumnalina), 3-(3',4'-diidroxibenzil)-5,8-diidroxi-7- metoxicroman-4-ona, 3-(3',4'-diidroxibenzilideno)-5,8-diidroxi-7- metoxicroman-4-ona e 3-(3',4'-diidroxibenzilideno)-5,7-diidroxi-6- metoxicroman-4-ona foram isolados dos bulbos da planta Scilla persica HAUSSKN. Suas estruturas foram estabelecidas com base na extensa análise espectroscópica, como RMN, EM, IV e UV.Medicinal plants have many traditional claims including the treatment of ailments of infectious origin. In the evaluation of traditional claims, scientific research is extremely important. In this study, five homoisoflavonoids named 3-(4'-hydroxybenzylidene)-5,7-dihydroxy-6-methoxychroman-4-one(Autumnalin),3-(4'-hydroxybenzyl)-5,7-dihydroxy-6-methoxychroman-4-one (3,9-dihydro-autumnalin), 3-(3',4'-dihydroxybenzyl)-5,8-dihydroxy-7-methoxychroman-4-one,3-(3',4'-dihydroxybenzylidene)-5,8-dihydroxy-7-methoxychroman-4-one and 3-(3',4'-dihydroxybenzylidene)-5,7-dihydroxy-6-methoxychroman-4-one, were isolated from the bulbs of the plant Scilla persica HAUSSKN. Their structures were established on the basis of extensive spectroscopic analyses such as NMR, MS, IR and UV

Enhancement of growth performance and hematological changes in rainbow trout (Onchorhynchus mykiss) alevins fed with Bifidobacterium bacteria

The study of probiotic application as an important rearing strategy was started more than 30 years ago and most of these studies were carried out to increase growth and survival of larvae. Effect of Bifidobacterium animalis PTTC-1631 and B. lactis PTTC-1736 as probiotic supplement has been studied on growth performance and hematological changes on rainbow trout, Oncorhynchus mykiss alevins with initial body weight of 0.583 ± 0.197 g. The commercial diet was supplemented with graded levels of probiotics (1×107, 2×107 and 3×107 CFU g-1 dry feed) to obtain 3 sets of experimental diets (T1, T2, and T3 respectively) and fed four times a day for 60 days. T1 alevin showed the best growth performance in terms of specific growth rate, weight gain, metabolic growth rate, feed conversion ratio and survival rate. The highest red and white blood cell concentrations were noticed in fish fed T2 and T3 diets, respectively, no significant difference was observed in hemoglobin content. T1 showed the significant elevation of serum biochemical parameters and reduction of cortisol level. The results of present study might suggest likely positive effects of probiotic supplements with concentration of 1×107 CFU g-1 dry feed on growth and hematology on rainbow trout alevins

Comparison of the Effect of Inhalational Isoflurane-Nitrous Oxide Anesthesia and Intravenous Propofol-Remifentanil Anesthesia on Postoperative Pain

Background: The severity of postoperative pain varies widely in the different types of anesthesia. The aim of the present study was to compare the effect of isoflurane-nitrous oxide anesthesia and propofol-remifentanil anesthesia on postoperative pain after foot and ankle surgery. Methods: In this double-blind clinical trial, 60 eligible patients were divided into two equal intervention and control groups; the first group inhaled anesthesia with isoflurane-nitrous oxide and the control group were given intravenous anesthesia with propofol-remifentanil using the quadruple random block model and postoperative pain intensity was measured and compared in the two groups. Data on pain severity were collected at different times and analyzed using SPSS statistical software and related tests. The significant level was set at 0.05.   Results: Of the 60 participants, 38 (52.4%) were male and 22 (47.6%) were female. The mean age of the participants was 33.9±15.1 years. The intensity of pain in the recovery room and up to 4 hours after surgery was significantly (Pvalue<0.001) lower in the intervention group but after 4 hours there was no significant difference between the two groups. So, it can be seen in the present study that there was a significant decrease (Pvalue<0.036) in the number of cases requiring analgesics prescribed in the recovery room and up to 4 hours after surgery in the intervention group. Conclusions: According to the results, evaporation anesthetic isoflurane-nitrous oxide can be used in the stage of induction of anesthesia in orthopedic surgeries, and has achieved good results in reducing pain, especially during the first 4 hours, postoperative. Key Words: Isoflurane, Propofol, Inhaler Anesthesia, IV Anesthesia, Postoperative Pai

Association between Serum Thyroid Hormones and Fatty Liver Disease

Background: Non-alcoholic fatty liver disease is one of the most common chronic liver diseases. Given the lack of definitive documentation for the effect of thyroid gland disorders on fatty liver, this study was conducted to determine the relationship between serum thyroid hormones levels and fatty liver in patients referring to Imam Hossain Hospital in Shahroud, in 2016.Methods: This case-control study was performed on 150 patients. The case group consisted of fatty liver patients whose disease was diagnosed based on laboratory and ultrasound findings, and a control group of patients with any other diseases without fatty liver. After liver ultrasonography, blood samples were taken from all patients and thyroid hormones levels were measured.Results: Of the 150 patients examined, the mean BMI of the patients was 24.79±6.9 kg / m2, which was significantly higher in the case group (P<0.012). The mean FBS level, was 131.5±83.5 mg / dl, which was significantly higher (P<0.001) in the case group. Similarly, the mean of TG was 245.5±128.5 mg / dl, which was significantly higher in the case group (P<0.047). On the other hand, the mean LDL of patients was 145.5±30.5 mg / dl, which was significantly higher (P<0.012) in patients with fatty liver. Further, the mean TSH of patients was significantly higher in the case group (P<0.014). Finally, there were no significant differences between the two groups regarding other variables.Conclusions: The results of this study suggested that thyroid gland disorders, especially hypothyroidism, were significantly higher in patients with fatty liver than in other patients. Nevertheless, they could not be influential in the incidence, exacerbation and persistence of fatty liver as a favorable factor

Association between Serum Thyroid Hormones and Fatty Liver Disease

Background: Non-alcoholic fatty liver disease is one of the most common chronic liver diseases. Given the lack of definitive documentation for the effect of thyroid gland disorders on fatty liver, this study was conducted to determine the relationship between serum thyroid hormones levels and fatty liver in patients referring to Imam Hossain Hospital in Shahroud, in 2016.Methods: This case-control study was performed on 150 patients. The case group consisted of fatty liver patients whose disease was diagnosed based on laboratory and ultrasound findings, and a control group of patients with any other diseases without fatty liver. After liver ultrasonography, blood samples were taken from all patients and thyroid hormones levels were measured.Results: Of the 150 patients examined, the mean BMI of the patients was 24.79±6.9 kg / m2, which was significantly higher in the case group (P<0.012). The mean FBS level, was 131.5±83.5 mg / dl, which was significantly higher (P<0.001) in the case group. Similarly, the mean of TG was 245.5±128.5 mg / dl, which was significantly higher in the case group (P<0.047). On the other hand, the mean LDL of patients was 145.5±30.5 mg / dl, which was significantly higher (P<0.012) in patients with fatty liver. Further, the mean TSH of patients was significantly higher in the case group (P<0.014). Finally, there were no significant differences between the two groups regarding other variables.Conclusions: The results of this study suggested that thyroid gland disorders, especially hypothyroidism, were significantly higher in patients with fatty liver than in other patients. Nevertheless, they could not be influential in the incidence, exacerbation and persistence of fatty liver as a favorable factor

Comparison of Diagnostic Value of ESR, CRP and Leukocytosis with Pathologic Findings among Patients with Acute Appendicitis

Background: Acute appendicitis is a serious condition that is occasionally falsely diagnosed. The correct diagnosis of this condition helps reduce unnecessary surgeries or complications due to the lack of diagnosis. Laboratory tests are used to diagnose this condition. The present study was conducted to compare the diagnostic value of the ESR, the CRP level and leukocytosis with pathological findings in patients with acute appendicitis.Methods: This descriptive study examined 125 cases with a primary diagnosis of appendicitis from August 2015 to October 2016 at Imam Hossein Hospital in Shahroud, Iran. The patients’ blood samples were collected for ESR, CRP and leukocyte testing and were then sent to the laboratory. After the appendectomies, samples of their appendices were sent to the pathology laboratory for further examination. The blood test results were compared with the pathological findings and analyzed in terms of sensitivity, specificity and positive and negative predictive values.Results: In this study, 59.2% of the cases were male and the rest were female. Acute appendicitis and other pathological appendices were confirmed in 91 patients (72.8%) based on their pathological evaluation and 34 cases (27.2%) were reported as normal. The sensitivity and specificity were obtained as 57.1% and 79.4% for ESR. These indices were 78.0% and 83.5% for CRP and 74.4% and 50% for leukocytosis.Conclusions: The results of this study showed that, in addition to basic laboratory findings, ESR, CRP and leukocytosis testing can also be helpful in the correct diagnosis of acute appendicitis; however, the predictive value of CRP was the highest

The Relationship between Uric Acid and Blood Glucose in Diabetic Patients

Background: some studies have shown that there is a correlation between serum uric acid and blood glucose levels so that these changes are not exactly clear. This study was conducted to determine the relationship between uric acid and blood glucose in diabetic patients. Methods: This cross-sectional study was performed on 190 type 2 diabetic (DM) patients in Shahroud by convenience sampling method. FBS, uric acid, triglyceride, and total cholesterol under standard conditions were measured. Patients were divided into four groups in terms of uric acid level. Results: In this study, 53.7% of patients were male. The average age of cases was 58.3 ± 13.5 years. There was a significant difference in uric acid between age groups (Pvalue<0.023), educational levels (Pvalue<0.041), BMI (Pvalue<0.012) and cholesterol (Pvalue<0.002) groups. Also, there was a significant reverse relationship between mean FBS (Pvalue<0.001), blood glucose two hours after feeding (Pvalue<0.001), and HbA1c (Pvalue<0.02) with different levels of uric acid. Conclusions: The results showed that there was a significant and reversal relationship between the levels of uric acid and glucose levels. In order to control the level of uric acid, the level of glucose in these patients is also to be measured and controlled. Keywords: Diabetes mellitus, Blood glucose, Uric acid.   &nbsp

Comparison of Diagnostic Value of ESR, CRP and Leukocytosis with Pathologic Findings among Patients with Acute Appendicitis

Background: Acute appendicitis is a serious condition that is occasionally falsely diagnosed. The correct diagnosis of this condition helps reduce unnecessary surgeries or complications due to the lack of diagnosis. Laboratory tests are used to diagnose this condition. The present study was conducted to compare the diagnostic value of the ESR, the CRP level and leukocytosis with pathological findings in patients with acute appendicitis.Methods: This descriptive study examined 125 cases with a primary diagnosis of appendicitis from August 2015 to October 2016 at Imam Hossein Hospital in Shahroud, Iran. The patients’ blood samples were collected for ESR, CRP and leukocyte testing and were then sent to the laboratory. After the appendectomies, samples of their appendices were sent to the pathology laboratory for further examination. The blood test results were compared with the pathological findings and analyzed in terms of sensitivity, specificity and positive and negative predictive values.Results: In this study, 59.2% of the cases were male and the rest were female. Acute appendicitis and other pathological appendices were confirmed in 91 patients (72.8%) based on their pathological evaluation and 34 cases (27.2%) were reported as normal. The sensitivity and specificity were obtained as 57.1% and 79.4% for ESR. These indices were 78.0% and 83.5% for CRP and 74.4% and 50% for leukocytosis.Conclusions: The results of this study showed that, in addition to basic laboratory findings, ESR, CRP and leukocytosis testing can also be helpful in the correct diagnosis of acute appendicitis; however, the predictive value of CRP was the highest

Outcomes and Risk Factors Associated with Burn Injuries in Children

Background: Burn injuries and their complications are still considered major threats to society’s health standards. The aim of this study was to describe the epidemiological profile, outcome, and factors associated with children’s burn injuries in Shahroud (northeastern Iran). Methods: This cross-sectional study was performed over a three-year period (2013–2015) on children 12 years and under who were admitted to Imam Hossein Hospital in Shahroud with burn injuries. In this study, we reviewed medical records of hospitalized burn patients, and an analysis was performed using SPSS software. Results: Of the 195 patients, 111 cases (56.9%) were male and the rest were female. The mean age was 6.34 ± 5.32 years (0–12 years). The highest proportion of burn injuries were in the 5- to 8-year-old group (47.2%), and the most common environment in which burn injuries occurred was the home (72.3%). The most common cause of burns was a hot liquid (56.9%). The mean TBSA was 20.11 ± 10.5% and the mean LHS was 9.81 ± 3.85 days. The most frequent burn areas were the upper limbs (46.6%), and second-degree burns were the most common type (48.2%). The mortality rate was 10.8%.Conclusions: The results of this study show that burn injuries in the pediatric population most commonly occur at home from a hot liquid, resulting in second-degree burns on upper-limb areas. So a large percentage of them are preventable with a little attention

Outcomes and Risk Factors Associated with Burn Injuries in Children

Background: Burn injuries and their complications are still considered major threats to society’s health standards. The aim of this study was to describe the epidemiological profile, outcome, and factors associated with children’s burn injuries in Shahroud (northeastern Iran). Methods: This cross-sectional study was performed over a three-year period (2013–2015) on children 12 years and under who were admitted to Imam Hossein Hospital in Shahroud with burn injuries. In this study, we reviewed medical records of hospitalized burn patients, and an analysis was performed using SPSS software. Results: Of the 195 patients, 111 cases (56.9%) were male and the rest were female. The mean age was 6.34 ± 5.32 years (0–12 years). The highest proportion of burn injuries were in the 5- to 8-year-old group (47.2%), and the most common environment in which burn injuries occurred was the home (72.3%). The most common cause of burns was a hot liquid (56.9%). The mean TBSA was 20.11 ± 10.5% and the mean LHS was 9.81 ± 3.85 days. The most frequent burn areas were the upper limbs (46.6%), and second-degree burns were the most common type (48.2%). The mortality rate was 10.8%.Conclusions: The results of this study show that burn injuries in the pediatric population most commonly occur at home from a hot liquid, resulting in second-degree burns on upper-limb areas. So a large percentage of them are preventable with a little attention