56 research outputs found

    Intersubject Regularity in the Intrinsic Shape of Human V1

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    Previous studies have reported considerable intersubject variability in the three-dimensional geometry of the human primary visual cortex (V1). Here we demonstrate that much of this variability is due to extrinsic geometric features of the cortical folds, and that the intrinsic shape of V1 is similar across individuals. V1 was imaged in ten ex vivo human hemispheres using high-resolution (200 ÎĽm) structural magnetic resonance imaging at high field strength (7 T). Manual tracings of the stria of Gennari were used to construct a surface representation, which was computationally flattened into the plane with minimal metric distortion. The instrinsic shape of V1 was determined from the boundary of the planar representation of the stria. An ellipse provided a simple parametric shape model that was a good approximation to the boundary of flattened V1. The aspect ration of the best-fitting ellipse was found to be consistent across subject, with a mean of 1.85 and standard deviation of 0.12. Optimal rigid alignment of size-normalized V1 produced greater overlap than that achieved by previous studies using different registration methods. A shape analysis of published macaque data indicated that the intrinsic shape of macaque V1 is also stereotyped, and similar to the human V1 shape. Previoud measurements of the functional boundary of V1 in human and macaque are in close agreement with these results

    Production of knowledge revisited - the impact of academic spin-offs on public research performance in Europe (PROKNOW): abbreviated description of the research project funded by the European Commission

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    "The EU-funded project 'Production of Knowledge Revisited: The Impact of Academic Spin-Offs on Public Research Performance in Europe (PROKNOW)' aims at analysing the interactions between public research institutions and academic spin-offs focussing on the impact of entrepreneurial activities on the academic research system. Based upon approaches in organisational sociology, science policy studies and science studies and analysing the gains and losses of spin-off activities for public research institutions, PROKNOW examines the relevance of public and private forms of knowledge in innovative processes of knowledge production. Academic spin-offs often epitomise innovative forms of knowledge production and are thus an exemplary topic to study innovation processes in the interaction of science, economy and society. PROKNOW proposes a European-wide comparison of research institutions in seven countries, including the three biggest research systems, Germany, France and the UK, and the -often considered to be innovative -systems of the Netherlands, Switzerland and Finland, and the associated candidate country Bulgaria. Institutionally, PROKNOW analyses different forms of public sector research institutions, university and extrauniversity institutions. In terms of economic sectors, the project focuses on life sciences, information sciences and nanotechnology. Thus, PROKNOW can help provide the institutional and organisational conditions for a profitable interaction between public research institutions and academic spin-offs." (author's abstract)"Das Eu-geförderte Projekt 'Production of Knowledge Revisited: The Impact of Academic Spin-Offs on Public Research Performance in Europe (PROKNOW)' analysiert Interaktionen zwischen öffentlichen Forschungseinrichtungen und deren akademischen Ausgründungen ('Spin-offs') und hat dabei die Folgen der unternehmerischen Aktivitäten auf das akademische Forschungssystem im Fokus. Auf der Grundlage von Ansätzen aus der Organisationssoziologie und der neueren Wissenschaftsforschung fragt das Projekt nach Gewinnen und Verlusten von Spin-off-Aktivitäten für öffentliche Forschungseinrichtungen und leistet damit einen Beitrag zur Erforschung zum Verhältnis öffentlicher und privater Wissensformen in innovativen Prozessen der Wissensproduktion. Anhand von akademischen Ausgründungen lassen sich Innovationsprozesse als Interaktion von Wissenschaft, Wirtschaft und Gesellschaft in exemplarischer Weise untersuchen. PROKNOW wird einen europaweiten Vergleich der Forschungseinrichtungen in sieben Ländern unternehmen. Ausgewählt wurden die drei größten Forschungssysteme, Deutschland, Frankreich und Großbritannien sowie die vielfach als innovativ eingeschätzten Systeme der Niederlande, der Schweiz und Finnlands und des EU-Beitrittskandidaten Bulgarien, die jeweils für avancierte Ansätze stehen. Dabei wird PROKNOW verschiedene Formen von öffentlichen Forschungseinrichtungen, universitäre und außeruniversitäre Einrichtungen analysieren. Das Projekt wird sich auf die Bereiche Biowissenschaften, Informations- und Nanotechnologien konzentrieren. Damit kann PROKNOW dazu beitragen, die institutionellen und organisatorischen Rahmenbedingungen für eine fruchtbare Interaktion von öffentlichen Forschungseinrichtungen und akademischen Spin-offs zu optimieren." (Autorenreferat

    Overview of the 3rd International Competition on Plagiarism Detection

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    [EN] This paper overviews eleven plagiarism detectors that have been developed and evaluated within PAN’11. We survey the detection approaches developed for the two sub-tasks “external plagiarism detection” and “intrinsic plagiarism detection,” and we report on their detailed evaluation based on the third revised edition of the PAN plagiarism corpus PAN-PC-11.This work was partly funded by the European Commission as part of the WIQEI IRSES project (grant no. 269180) within the FP7 Marie Curie People Framework, by MICINN as part of the TextEnterprise 2.0 project (TIN2009-13391-C04-03) within the Plan I+D+i, and as part of the VLC/CAMPUS Microcluster on Multimodal Interaction in Intelligent Systems.Potthast, M.; Eiselt, A.; Barrón Cedeño, LA.; Stein, B.; Rosso, P. (2011). Overview of the 3rd International Competition on Plagiarism Detection. CEUR Workshop Proceedings. 1177. http://hdl.handle.net/10251/46639S117

    Frequency and Nature of Incidental Extra-Enteric Lesions Found on Magnetic Resonance Enterography (MR-E) in Patients with Inflammatory Bowel Diseases (IBD)

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    The aim of this study was to determine the occurrence of extra-enteric findings in a large cohort of patients undergoing magnetic resonance enterography (MR-E) and to classify the clinical significance of these findings.We retrospectively analyzed 1154 MR-E performed in 1006 patients referred to our radiological department between 1999-2005. The reasons for referral were suspected or proven inflammatory bowel diseases (IBD) (n = 710), further diagnostic work-up for small bowel disease because of non-specific abdominal symptoms (SBD; n = 182) or suspected small bowel malignancies (SBM; n = 114). All extra-enteric findings were reviewed by a radiologist and a gastroenterologist and were classified as having high, moderate, or low significance for further diagnostic or therapeutic procedures.The average age of all patients was 40+/-16 (Mean+/-SD) years (y) (IBD 35+/-13 y; SBD 49+/-16 y; SBM 57+/-15 y). A total of 1113 extra-enteric findings were detected in 600 of 1006 patients (59.6%). Of these findings 180 (16.2%) were judged as having a high, 212 (19.0%) a moderate and 721 (64.8%) a low significance. On a per group basis in patients with IBD 12.0% of the findings were of major clinical significance compared to 13.7% and 33.3% in patients with SBD and SBM, respectively. The most common major findings were abscesses (69.9%) in the IBD group and extraintestinal tumors, metastases or masses in the SBD and SBM groups (41.9% and 74.2%, respectively).MR-E reveals a substantial number of extra-enteric findings, supporting the role of a cross-sectional imaging method for the evaluation of the small bowel

    Integration und Desintegration der Kulturen im europäischen Mittelalter

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    Das mittelalterliche Europa war keine christliche Einheitskultur, sondern geprägt von vielfältigen Prozessen des Kontakts und der Abgrenzung zwischen Kulturen, bei denen die drei monotheistischen Religionen Christentum, Judentum und Islam eine herausragende Rolle spielten. Seit 2005 erforscht das DFG-Schwerpunktprogramm "Integration und Desintegration der Kulturen im europäischen Mittelalter" die Geschichte Europas als Geschichte kultureller Differenzen. Der Band dokumentiert die Dynamiken und Erträge eines wissenschaftsorganisatorischen Experiments: Gegliedert in fächerübergreifende Arbeitsgruppen, erforschten 24 Einzelprojekte aus 14 Disziplinen Integrations- und Desintegrationsprozesse von Skandinavien bis Ägypten, von der Iberischen Halbinsel bis zu den Steppen Zentralasiens in komparativem Zugriff; sie präsentieren ihre Ergebnisse nun in Beiträgen, die von mehreren Autorinnen und Autoren gemeinsam verfasst worden sind. Dabei werden Begriffe wie "Kultur" problematisiert und schon eingeführte Konzepte wie "Integration/Desintegration", "Inklusion/Exklusion", "Hybridisierung" und "Transfer" als Instrumente transkultureller Mediävistik auf den Prüfstand gestellt. Das Ende der Laufzeit des Schwerpunktprogramms gibt zugleich Anlass, methodisch-theoretische Einsichten der gemeinsamen Forschung wie auch praktische Erfahrungen bei der transdisziplinären Zusammenarbeit zu bilanzieren
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