Motivation and attitudes toward changing health (MATCH): A new patient-reported measure to inform clinical conversations.

ObjectiveTo identify and assess patient motivation to initiate or maintain behavior changes.MethodsAttitudinal statements were developed from structured patient interviews and translated into 18 survey items. Items were analyzed with exploratory factor analysis (EFA).ResultsAn EFA with 340 type 2 diabetes patients identified three areas of patient attitudes toward changing health behaviors: (1) willingness to make changes (3 items; α = 0.69), (2) perceived ability to make or maintain changes (3 items; α = 0.74), and (3) and feeling changes are worthwhile (3 items; α = 0.61). Greater perceived ability and feelings of worthwhileness were associated with positive psychosocial and behavioral management indicators. All three areas were associated with confidence and attitudes toward making a specific behavioral change (e.g., improve diet).ConclusionsMATCH is an internally consistent and valid 9-item scale that provides a profile of factors influencing motivation that can be used in clinical and research settings

Quantum spin liquids and the metal-insulator transition in doped semiconductors

We describe a new possible route to the metal-insulator transition in doped semiconductors such as Si:P or Si:B. We explore the possibility that the loss of metallic transport occurs through Mott localization of electrons into a quantum spin liquid state with diffusive charge neutral "spinon" excitations. Such a quantum spin liquid state can appear as an intermediate phase between the metal and the Anderson-Mott insulator. An immediate testable consequence is the presence of metallic thermal conductivity at low temperature in the electrical insulator near the metal-insulator transition. Further we show that though the transition is second order the zero temperature residual electrical conductivity will jump as the transition is approached from the metallic side. However the electrical conductivity will have a non-monotonic temperature dependence that may complicate the extrapolation to zero temperature. Signatures in other experiments and some comparisons with existing data are made.Comment: 4 pages text + 3 pages Appendices, 3 Figures; v2 - References Adde

Steroid sulfatase:a pivotal player in estrogen synthesis and metabolism

International audienceSteroid sulfatase plays a pivotal role in regulating the formation of biologically active steroids from inactive steroid sulfates. It is responsible for the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone, respectively, both of which can be subsequently reduced to steroids with estrogenic properties (i.e. estradiol and androstenediol) that can stimulate the growth of tumors in hormone-responsive tissues of the breast, endometrium and prostate. Hence, the action of steroid sulfatase is implicated in physiological processes and pathological conditions. It has been five years since our group last reviewed the important role of this enzyme in steroid synthesis and the progress made in the development of potent inhibitors of this important enzyme target. This timely review therefore concentrates on recent advances in steroid sulfatase research, and summarises the findings of clinical trials with Irosustat (BN83495), the only steroid sulfatase inhibitor that is being trialed in postmenopausal women with breast or endometrial cancer

Machine Induced Background in the Low Luminosity Insertions of the LHC

The effect of the machine induced background is studied for the low luminosity insertions of the LHC. Estimations for the fluxes of the secondary particles, induced by the proton losses in the LHC, are presented for several running conditions of the collider. The formation of the background in the machine structure is discussed

SHIP2:structure, function and inhibition

SHIP2 is a phosphatase that acts at the 5-position of phosphatidylinositol 3,4,5-trisphosphate. It is one of several enzymes that catalyse dephosphorylation at the 5-position of phosphoinositides or inositol phosphates. SHIP2 has a confirmed role in opsismodysplasia, a disease of bone development, but also interacts with proteins involved in insulin signalling, cytoskeletal function (thus having an impact on endocytosis, adhesion, proliferation and apoptosis) and immune system function. The structure of three domains (constituting about 38% of the protein) is known. Inhibitors of SHIP2 activity have been designed to interact with the catalytic domain with sub-micromolar IC50 values: these come from a range of structural classes and have been shown to have in vivo effects consistent with SHIP2 inhibition. Much remains unknown about the roles of SHIP2 and possible future directions for research are indicated

Synthesis and in vitro antimicrobial SAR of benzyl and phenyl guanidine and aminoguanidine hydrazone derivatives

A series of benzyl, phenyl guanidine, and aminoguandine hydrazone derivatives was designed and in vitro antibacterial activities against two different bacterial strains (Staphylococcus aureus and Escherichia coli) were determined. Several compounds showed potent inhibitory activity against the bacterial strains evaluated, with minimal inhibitory concentration (MIC) values in the low µg/mL range. Of all guanidine derivatives, 3-[2-chloro-3-(trifluoromethyl)]-benzyloxy derivative 9m showed the best potency with MICs of 0.5 µg/mL (S. aureus) and 1 µg/mL (E. coli), respectively. Several aminoguanidine hydrazone derivatives also showed good overall activity. Compounds 10a, 10j, and 10r–s displayed MICs of 4 µg/mL against both S. aureus and E. coli. In the aminoguanidine hydrazone series, 3-(4-trifluoromethyl)-benzyloxy derivative 10d showed the best potency against S. aureus (MIC 1 µg/mL) but was far less active against E. coli (MIC 16 µg/mL). Compound 9m and the para-substituted derivative 9v also showed promising results against two strains of methicillin-resistant Staphylococcus aureus (MRSA). These results provide new and potent structural leads for further antibiotic optimisation strategies

Synthesis and in vitro antimicrobial SAR of benzyl and phenyl guanidine and aminoguanidine hydrazone derivatives

A series of benzyl, phenyl guanidine and aminoguandine hydrazone derivatives was designed and in vitro antibacterial activities against two different bacterial strains (Staphylococcus aureus and Escherichia coli) were determined. Several compounds showed potent inhibitory activity against the bacterial strains evaluated, with minimal inhibitory concentration (MIC) values in the low μg/mL range. Of all guanidine derivatives, 3-[2-chloro-3-(trifluoromethyl)]-benzyloxy deriva-tive 9m showed the best potency with MICs of 0.5 μg/mL (S. aureus) and 1 μg/mL (E. coli), respec-tively. Several aminoguanidine hydrazone derivatives also showed good overall activity. Com-pounds 10a, 10j and 10r-s displayed MICs of 4 μg/mL against both S. aureus and E. coli. In the ami-noguanidine hydrazone series, 3-(4-trifluoromethyl)-benzyloxy derivative 10d showed the best po-tency against S. aureus (MIC 1 μg/mL), but was far less active against E. coli (MIC 16 μg/mL). Com-pound 9m and the para-substituted derivative 9v also showed promising results against two strains of methicillin-resistant Staphylococcus aureus (MRSA). These results provide new and potent struc-tural leads for further antibiotic optimisation strategies

V405 Aurigae: A High Magnetic Field Intermediate Polar

Our simultaneous multicolor (UBVRI) circular polarimetry has revealed nearly sinusoidal variation over the WD spin cycle, and almost symmetric positive and negative polarization excursions. Maximum amplitudes are observed in the B and V bands (+-3 %). This is the first time that polarization peaking in the blue has been discovered in an IP, and suggests that V405 Aur is the highest magnetic field IP found so far. The polarized flux spectrum is similar to those found in polars with magnetic fields in the range B ~ 25-50 MG. Our low resolution circular spectropolarimetry has given evidence of transient features which can be fitted by cyclotron harmonics n = 6, 7, and 8, at a field of B = 31.5 +- 0.8 MG, consistent with the broad-band polarized flux spectrum. Timings of the circular polarization zero crossovers put strict upper limits on WD spin period changes and indicate that the WD in V405 Aur is currently accreting closely at the spin equilibrium rate, with very long synchronization timescales, T_s > 10^9 yr. For the observed spin to orbital period ratio, P_{spin}/P_{orb} = 0.0365, and P_{orb} ~ 4.15 hr, existing numerical accretion models predict spin equilibrium condition with B ~ 30 MG if the mass ratio of the binary components is q_1 ~ 0.4. The high magnetic field makes V405 Aur a likely candidate as a progenitor of a polar.Comment: To appear in The Astrophysical Journal, September 1 Issue (2008), 9 pages, 10 figure