Effects of a Unilateral Strength and Plyometric Training Program for Division I Soccer Players

The current thesis examined the effects of a unilateral strength and plyometric program on power (bilateral and unilateral vertical jumps), speed (20 meter sprint), and agility (Agility T- Test) in collegiate soccer players compared to a traditional bilateral-based training program. Due to the fact that a majority of the research on performance variables in athletes is done using bilateral lifting and plyometric programs, yet most movements in field sports such as sprinting and changing direction are unilateral-based, this specific topic could have value for enhanced performance for athletic populations. The participants included 34 male and female Division-I soccer players who were paired up and then randomly assigned to a six week unilateral-based or bilateral-based training program. Pre and post tests were conducted prior to and after the six week training, respectively. In relation to pretest results, athletes’ bilateral vertical jump, unilateral vertical jump, 20 meter sprint, and T-Agility Test increased after six week training. The test scores were significantly correlated. Multivariate analysis of covariance results showed that pretest co- variates were significant predictors for the corresponding posttest outcome, yet there was not a significant difference between the unilateral and bilateral training group’s improvements (Wilks’ λ = .88, F3,13 = .37, p = .86). Athletes in the unilateral training group scored slightly better than those in the bilateral training group, yet not significantly. This study demonstrated the value of a unilateral program on power, speed, and agility, but more research has to be conducted to deter- mine if it could actually be a more optimal program than a traditional bilateral-based program

Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy

BACKGROUND: Diabetic nephropathy is the leading cause of end stage renal disease. All three cell types of the glomerulus, podocytes, endothelial cells and mesangial cells, play important roles in diabetic nephropathy. In this report we used Meis1-GFP transgenic mice to purify mesangial cells from normal mice and from db/db mice, which suffer diabetic nephropathy. The purpose of the study is to better define the unique character of normal mesangial cells, and to characterize their pathogenic and protective responses during diabetic nephropathy. METHODS: Comprehensive gene expression states of the normal and diseased mesangial cells were defined with microarrays. By comparing the gene expression profiles of mesangial cells with those of multiple other renal cell types, including podocytes, endothelial cells and renal vesicles, it was possible to better define their exceptional nature, which includes smooth muscle, phagocytic and neuronal traits. RESULTS: The complete set of mesangial cell expressed transcription factors, growth factors and receptors were identified. In addition, the analysis of the mesangial cells from diabetic nephropathy mice characterized their changes in gene expression. Molecular functions and biological processes specific to diseased mesangial cells were characterized, identifying genes involved in extracellular matrix, cell division, vasculogenesis, and growth factor modulation. Selected gene changes considered of particular importance to the disease process were validated and localized within the glomuerulus by immunostaining. For example, thrombospondin, a key mediator of TGFβ signaling, was upregulated in the diabetic nephropathy mesangial cells, likely contributing to fibrosis. On the other hand the decorin gene was also upregulated, and expression of this gene has been strongly implicated in the reduction of TGFβ induced fibrosis. CONCLUSIONS: The results provide an important complement to previous studies examining mesangial cells grown in culture. The remarkable qualities of the mesangial cell are more fully defined in both the normal and diabetic nephropathy diseased state. New gene expression changes and biological pathways are discovered, yielding a deeper understanding of the diabetic nephropathy pathogenic process, and identifying candidate targets for the development of novel therapies

Book Reviews

Reviews of the following books: Maine: A Bibliography of Its History by John D. Haskell, Jr.; Tombstones and Paving Blocks: The History of the Granite Industry in Maine by Roger E. Grindle; Josiah Volunteered: A Collection of Diaries, Letters and Photographs of Josiah H. Sturtevant, His Wife Helen and His Four Children edited by Arnold H. Sturtevan

Rare and exotic mineralogy of the western subcomplex of the Deadhorse Creek "diatreme", Northwestern Ontario

The Deadhorse Creek ‘Diatreme’ is a Proterozoic vent breccia that probably formed in response to early mid-continent rifting. Following emplacement of the breccia, the western subcomplex experienced three alteration events, producing the complex mineralogy observed in the main mineralized zone. Each event has produced a unique mineral paragenesis and the timing o f each has been deduced from both textural and compositional evidence. While independent, these events made use o f the same pre-existing fracture system along which the western subcomplex is situated. In order, these events were: intrusion o f granitic fluids, alkaline metasomatism, and thermal metamorphism due to the emplacement o f the Coldwell alkaline complex. Following the alteration events, and presumably a result o f denudation, oxidization and leaching o f the main mineralized zone has produced a supergene paragenesis of: calcite, tyuyamunite, hollandite and barite. The main mineralized zone was enriched in first- and second-row transition metals, rare-earth elements, beryllium, Th and U. The mineralization is represented by the presence of: aegirine-jervisite, aegirine-natalyite, barite, baryhte, hollandite, coffinite, hematite, Umenorutile, magnetite, monazite-(Ce), phenakite, pyrite, rutile, thorite, thorogummite, thortveitite, tyuyamunite, uraninite, V-crichtonite, xenotime-(Y), zircon, zircon-thorite-coffinite solid solutions and a few unnamed mineral species. The resulting mineralogy is both unique and complex, with several rare minerals and new compositional extremes reported (i.e., Nb-V-rutile, aegirine-jervisite, aegifine-natalyite, zircon-thorite-coffinite solid solutions, Dy-xenotdme-(Y), thortveitite, baotite, barylite and Vcrichtonite). In addition, unique parageneses are reported, giving further insight into the geochemistry o f Be, Ba, Sc, V, N b, Ti and Cr and conditions of formation of phenakite, baryhte, thortveitite, crichtonite, ilmenorutile, barian feldspars and zircon-thorite-coffinite solid solutions

Determination of monocular and binocular field preferences and their relationships to eye dominancy

Determination of monocular and binocular field preferences and their relationships to eye dominanc

Pretreatment of Human Cerebrovascular Endothelial Cells with CO-releasing Molecule-3 Interferes with JNK/AP-1 Signaling and Suppresses LPS-induced Proadhesive Phenotype.

OBJECTIVE: Exogenously administered CO interferes with PMN recruitment to the inflamed organs. The mechanisms of CO-dependent modulation of vascular proadhesive phenotype, a key step in PMN recruitment, are unclear. METHODS: We assessed the effects/mechanisms of CO liberated from a water-soluble CORM-3 on modulation of the proadhesive phenotype in hCMEC/D3 in an in vitro model of endotoxemia. To this end, hCMEC/D3 were stimulated with LPS (1 μg/mL) for six hours. In some experiments hCMEC/D3 were pretreated with CORM-3 (200 μmol/L) before LPS-stimulation. PMN rolling/adhesion to hCMEC/D3 were assessed under conditions of laminar shear stress (0.7 dyn/cm(2) ). In parallel, expression of adhesion molecules E-selectin, ICAM-1, and VCAM-1 (qPCR), activation of transcription factors, NF-κB and AP-1 (ELISA), and MAPK-signaling (expression/phosphorylation of p38, ERK1/2, and JNK1/2; western blot) were assessed. RESULTS: The obtained results indicate that CORM-3 pretreatment reduces PMN rolling/adhesion to LPS-stimulated hCMEC/D3 (p \u3c 0.05). Decreased PMN rolling/adhesion to hCMEC/D3 was associated with CORM-3-dependent inhibition of MAPK JNK1/2 activation (Tyr-phosphorylation), inhibition of transcription factor, AP-1 (c-Jun phosphorylation), and subsequent suppression of VCAM-1 expression (p \u3c 0.05). CONCLUSIONS: These findings indicate that CORM-3 pretreatment interferes with JNK/AP-1 signaling and suppresses LPS-induced upregulation of the proadhesive phenotype in hCMEC/D3

Evidence for Cyclical Fractional Crystallization, Recharge, and Assimilation in Basalts of the Kimama Drill Core, Central Snake River Plain, Idaho: 5.5-Million-Years of Petrogenesis in a Mid-crustal Sill Complex

Basalts erupted in the Snake River Plain of central Idaho and sampled in the Kimama drill core link eruptive processes to the construction of mafic intrusions over 5.5 Ma. Cyclic variations in basalt composition reveal temporal chemical heterogeneity related to fractional crystallization and the assimilation of previously-intruded mafic sills. A range of compositional types are identified within 1,912 m of continuous drill core: Snake River olivine tholeiite (SROT), low K SROT, high Fe-Ti, and evolved and high K-Fe lavas similar to those erupted at Craters of the Moon National Monument. Detailed lithologic and geophysical logs document 432 flow units comprising 183 distinct lava flows and 78 flow groups. Each lava flow represents a single eruptive episode, while flow groups document chemically and temporally related flows that formed over extended periods of time. Temporal chemical variation demonstrates the importance of source heterogeneity and magma processing in basalt petrogenesis. Low-K SROT and high Fe-Ti basalts are genetically related to SROT as, respectively, hydrothermally-altered and fractionated daughters. Cyclic variations in the chemical composition of Kimama flow groups are apparent as 21 upward fractionation cycles, six recharge cycles, eight recharge-fractionation cycles, and five fractionation-recharge cycles. We propose that most Kimama basalt flows represent typical fractionation and recharge patterns, consistent with the repeated influx of primitive SROT parental magmas and extensive fractional crystallization coupled with varying degrees of assimilation of gabbroic to ferrodioritic sills at shallow to intermediate depths over short durations. Trace element models show that parental SROT basalts were generated by 5–10% partial melting of enriched mantle at shallow depths above the garnet-spinel lherzolite transition. The distinctive evolved and high K-Fe lavas are rare. Found at four depths, 319, 1045, 1,078, and 1,189 m, evolved and high K-Fe flows are compositionally unrelated to SROT magmas and represent highly fractionated basalt, probably accompanied by crustal assimilation. These evolved lavas may be sourced from the Craters of the Moon/Great Rift system to the northeast. The Kimama drill core is the longest record of geochemical variation in the central Snake River Plain and reinforces the concept of magma processing in a layered complex