[M(CQ)2] complexes (M = Ni, Pd and Pt, CQ = clioquinol) - analogues of carboplatin

Otrzymano związki koordynacyjne [M(CQ)2] (M = Ni, Pd lub Pt, CQ = 5-chloro-7-jodo-chinolin-8-ol, kliochinol) i zbadano za pomocą spektroskopii w podczerwieni i analizy termicznej. Na podstawie rentgenografii strukturalnej stwierdzono, że kompleksy [Ni(CQ)2] i [Pd(CQ)2] są molekularnymi związkami koordynacyjnymi z atomami centralnymi, wokół których skoordynowane są w układzie płaskim kwadratowym atomy azotu i tlenu dwóch dwukleszczowych cząsteczek kliochinolu w konfiguracji trans. Zbadano również oddziaływania niewiążące w tych dwu kompleksach. Struktury krystalicznej [Pt(CQ)2] nie ustalono, ale na podstawie dyfraktogramów proszkowych stwierdzono, że wszystkie trzy badane kompleksy są izostrukturalne. Oceniono aktywność biologiczną tych związków.[M(CQ)2] (M = Ni, Pd or Pt, CQ = 5-chloro-7-iodo-quinolin-8-ol, clioquinol) coordination compounds were prepared and characterized by infrared spectroscopy and thermal analysis. X-ray structure analysis revealed that the [Ni(CQ)2] and [Pd(CQ)2] complexes are molecular coordination compounds with central atoms square-planarly coordinated by nitrogen and oxygen atoms of two trans-arranged bidentate molecules of clioquinol. Nonbonding interactions in these two complexes were also investigated. The crystal structure of [Pt(CQ)2] was not solved but according to powder diffractograms of all three prepared complexes, all complexes are isostructural. Biological activities of these compounds were evaluated

Experimental Study of the Magnetocaloric Effect in Ni(en)(H 2

Magnetocaloric properties of Ni(en)(H₂O)₄SO₄·2H₂O powder were investigated in temperature range from 2 K to 30 K in magnetic fields up to 7 T using isothermal magnetization measurements. The maximum value of the isothermal entropy change in the field 7 T is about 8 J/(kg K), with a refrigerant capacity of 55 J/kg. Temperature dependence of the isothermal entropy change under different magnetic fields is in good agreement with theoretical predictions from crystal electric field parameters

Experimental Study of the Magnetocaloric Effect in Ni(en)(H₂O)₄SO₄·2H₂O - An S = 1 Molecular Magnet with Easy-Plane Anisotropy

Magnetocaloric properties of Ni(en)(H₂O)₄SO₄·2H₂O powder were investigated in temperature range from 2 K to 30 K in magnetic fields up to 7 T using isothermal magnetization measurements. The maximum value of the isothermal entropy change in the field 7 T is about 8 J/(kg K), with a refrigerant capacity of 55 J/kg. Temperature dependence of the isothermal entropy change under different magnetic fields is in good agreement with theoretical predictions from crystal electric field parameters

[Ni(en)(H2O)4][SO4]⋅2H2O[Ni(en)(H_2O)_4][SO_4] \cdot 2H_2O - an S = 1 Molecular Magnet with Easy-Plane Anisotropy

Structural analysis of $[Ni(en)(H_2O)_4][SO_4] \cdot 2H_2O$ was performed and it suggests that the crystal field should play a dominant role in the magnetic properties of the system. This conjecture coincides well with the specific heat and susceptibility behaviour. The analysis confirmed that the compound can be treated as a spin 1 single molecule magnet with nonmagnetic ground state introduced by easy-plane single-ion anisotropy D/$k_B$≈11 K and neglecting in-plane anisotropy E/D <0.1

Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent

© 2019 Dušan S. Dimić et al. The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography. It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure. The compound was tested in vitro against different cell lines, healthy human keratinocyte HaCaT, cervical squamous cell carcinoma SiHa, breast carcinoma MCF7, and hepatocellular carcinoma HepG2. Compared to control, the new derivate showed a stronger effect on both healthy and carcinoma cell lines, with the most prominent effect on the breast carcinoma MCF7 cell line. The molecular docking study, obtained for ten different conformations of the new compound, showed its inhibitory nature against CDK S protein. Lower inhibition constant, relative to one of 4-OH-coumarine, proved stronger and more numerous interactions with CDK S protein. These interactions were carefully examined for both parent molecule and derivative and explained from a structural point of view