6,899 research outputs found
Three dimensional imaging of short pulses
We exploit a slightly noncollinear second-harmonic cross-correlation scheme
to map the 3D space-time intensity distribution of an unknown complex-shaped
ultrashort optical pulse. We show the capability of the technique to
reconstruct both the amplitude and the phase of the field through the coherence
of the nonlinear interaction down to a resolution of 10 m in space and 200
fs in time. This implies that the concept of second-harmonic holography can be
employed down to the sub-ps time scale, and used to discuss the features of the
technique in terms of the reconstructed fields.Comment: 16 pages, 6 figure
Dynamic heterodyne near field scattering
The technique heterodyne near field scattering (HNFS), originally developed for low-angle static light scattering, has also been implemented for carrying out dynamic light scattering. While the classical dynamic light scattering method measures the intensity-intensity correlation function, dynamic HNFS gives directly the field-field correlation function, without any assumption on the statistical properties of the sample, as the ones required by the Siegert relation. The technique has been tested with calibrated Brownian particles and its performances compared to those of the classical dynamic light scattering method.The technique heterodyne near field scattering (HNFS), originally developed for low-angle static light scattering, has also been implemented for carrying out dynamic light scattering. While the classical dynamic light scattering method measures the intensity-intensity correlation function, dynamic HNFS gives directly the field-field correlation function, without any assumption on the statistical properties of the sample, as the ones required by the Siegert relation. The technique has been tested with calibrated Brownian particles and its performances compared to those of the classical dynamic light scattering method. \ua9 2008 American Institute of Physics
Heterodyne near-field scattering: A technique for complex fluids
The heterodyne near-field scattering (HNFS) technique for studying complex fluids such as colloidal systems was discussed. A different data reduction scheme was adopted which allowed the improvement in performance of the technique, at levels of sensitivity and accuracy much higher than those achievable with classical low-angle light scattering instrumentation. It was observed that this method also relaxes the requirements on the optical/mechanical stability of the experimental setup and allows for a real time analysis. Nonstationary samples, such as aggregating colloidal solutions, were also investigated, and their kinetics quantitatively characterized
Heterodyne speckle velocimetryof Poiseuille flow
We review the technique named heterodyne speckle velocimetry and present two applications for
testing the method with a fluid moving under the conditions of Poiseuille flow. The fluid was seeded
with small tracking particles diameter 300 nm and fluxed between the two parallel planes of a cell
with constant or variable cross section. In the first case the velocity distribution was constant along
the direction parallel to the planes and was in excellent agreement with the expected Poiseuille
profile along the orthogonal direction. In the second case, where velocity gradients were present also
along the planes, the technique was able to reconstruct both the orthogonal Poiseuille profile and the
in-plane two dimensional mapping of the velocity vectors, with the possibility of measuring the fluid
flux within an accuracy of 1%
A New Method for the Solution and Solid Phase Synthesis of Chiral b-Sulfonopeptides Under Mild Conditions.
Acceleration of hemiacetal cleavage through hydrogen bonding : a new synthetic catalyst with balanced conformational flexibility and preorganization
Hemiacetal cleavage catalyst 1 was designed, synthesized, and shown to be effective in promoting glycolaldehyde dimer dissociation and tetramethylglucose mutarotation
Solid-phase synthesis of peptides containing reverse-turn mimetic bicyclic lactams
The solid-phase synthesis and characterization of a series of peptides (4-15) containing reverse-turn mimetic bicyclic lactams is reported. The bicyclic lactams (1a, 1b) possess high structural similarity to the two central residues of a Pturn. Amino acid conjugates of these bicyclic lactams were synthesized on solid supports following a g-fluorenylmethoxycarbonyl (FMOC) protection strategy on WangMerrifield resin. Coupling between amino acids was accomplished by means of diisopropylcarbodiimide (DIC)/ hydroxyazabenzotriazole (HOAt). Coupling between amino acids and the mimics was performed with the potent Carpino's reagent O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramelhyluronium hexafluorophosphate (HATU). The final compounds were cleaved from the resin and obtained as N-acetylated methyl esters or benzyl amides
Use of biological drugs in patients with psoriasis and psoriatic arthritis in italy: Results from the PSONG survey
This Italian multicenter retrospective study compared the drug survival and efficacy of differentanti-TNF agents in psoriasis (PsO) and psoriatic arthritis (PsA) patients. A database of PsO/PsApatients treated with adalimumab, etanercept, and infliximab from May 2013 to May 2014 wasanalyzed. PASI 75, 90, and 100 was calculated at each time point to evaluate efficacy. Drug sur-vival rate and probability of maintaining PASI response were evaluated. The impact of dependentvariables on probability of PASI 75 loss was evaluated by logistic regression. 1,235 patients wereincluded, 577 with PsO and 658 with PsA. Highest survival rates were observed with adalimumabfollowed by etanercept and infliximab in PsO and PsA patients. The probability of maintainingPASI response was significantly higher for adalimumab followed by infliximab. For PsO patients,the odds of losing PASI 75 was higher in etanercept-treated patients (OR: 8.1; 95% CI: 4.2–15.6,p<.001) or infliximab (OR: 6.6; 95% CI: 2.6–16.3,p<.001) vs. adalimumab. Likewise, for PsApatients the odds of losing PASI 75 was higher in etanercept-treated patients (OR: 2.3; 95% CI:1.4–3.8,p5.01) or infliximab (OR: 2.2; 95% CI: 1.1–4.1,p5.018) vs. adalimumab. Adalimumabcould be the best therapeutic option over other anti-TNF agents for the treatment of PsO and PsApatients
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