Intramolecular arylation of benzimidazoles via Pd(II)/Cu(I) catalyzed cross-dehydrogenative coupling

Electron poor benzimidazole substrates were arylated via an intramolecular cross-dehydrogenative coupling (CDC) reaction. These CDC reactions were catalyzed by a Pd(II)/Cu(I) catalyst system, capable of producing moderate yields on a large library of substrates. The substrate scope consisted of tethered arene-benzimidazoles that upon coupling, produced a fused polycyclic motif. [Refer to PDF for graphical abstract

Clustered engine study

Several topics are presented in viewgraph form which together encompass the preliminary assessment of nuclear thermal rocket engine clustering. The study objectives, schedule, flow, and groundrules are covered. This is followed by the NASA groundrules mission and our interpretation of the associated operational scenario. The NASA reference vehicle is illustrated, then the four propulsion system options are examined. Each propulsion system's preliminary design, fluid systems, operating characteristics, thrust structure, dimensions, and mass properties are detailed as well as the associated key propulsion system/vehicle interfaces. A brief series of systems analysis is also covered including: thrust vector control requirements, engine out possibilities, propulsion system failure modes, surviving system requirements, and technology requirements. An assessment of vehicle/propulsion system impacts due to the lessons learned are presented

Insight into the palladium catalyzed oxidative arylation of benzofuran: Heteropoly acid oxidants evoke a Pd(II)/Pd(IV) mechanism

The effects of oxidant and organic acid additives on the oxidative cross-coupling reactions of electron rich heterocycles such as benzofuran with benzene were studied. Both regioselectivity and reaction rate could be controlled by varying the condition parameters. Furthermore, mechanistic insight was achieved via kinetic studies which indicate that reactions that are oxidized by the heteropoly acid H4PMo11VO40 operate via a Pd(II)/Pd(IV) mechanisms, while reactions oxidized by either AgOAc or Cu(OAc)2 operate by a Pd(II)/Pd(0) mechanism

UNLV College of Education Multicultural & Diversity Newsletter

A newsletter discussing a variety of topics dealing with multicultural topics and diversity in education

UNLV College of Education Multicultural & Diversity Newsletter

Each morning I wound my way up the steep hill along the deeply rutted dirt path, exchanging daily maaa\u27s with five bleating sheep and shouting out, ¡Hola! in response to the children who gleefully identified me as ¡Gringa! Women and children, colorful bowls of cooked maize balanced atop their heads, sauntered to and from Maria Elena\u27s where their maize would be ground; at home the dough would be shaped and flattened into tortillas, the mainstay of every meal in the small Guatemalan village of San Juan

Pharmacist impact on medication reconciliation of behavioral health patients boarding in the emergency department

Introduction: The high demand for psychiatric services has exceeded the capacity of available resources for behavioral health patients, forcing these patients to seek mental health care in the emergency department. Average lengths of stay for behavioral health boarders commonly extend over multiple days and prior-to-admission (PTA) medication administration may be delayed, which could lead to further deterioration and longer inpatient lengths of stay. Addition of a pharmacist-led medication reconciliation process and pharmacist integration into daily emergency department psychiatry rounds may decrease time to initiation of PTA medications and improve outcomes in this population. Methods: This is a retrospective review of adult patients who required a psychiatric emergency evaluation in a large rural academic medical center emergency department. Objectives were to determine the number and type of medication discrepancies found with pharmacist intervention, and to compare time to initiation of PTA medications with a pharmacist versus a nonpharmacist completing medication reconciliation. Results: A total of 139 patients were identified, 85 patients in August 2019 (no pharmacist [NP]) and 54 in October 2019 (pharmacist involvement [PI]). Among 484 medications reviewed in the PI group, 298 discrepancies were identified. The most common types of discrepancies were no longer taking (n = 99, 33%) and omission (n = 94, 32%). Time to administration of PTA medications was similar between NP and PI groups (median hours, interquartile range: NP: 10.8, 7.8-16.57; PI: 11.49, 6.16-16; P = .179). Discussion: This study depicted one of the many values of pharmacists in the hospital setting, especially in the behavioral health patient population where continuation of accurate PTA medications may prevent further clinical deterioration

Galaxy And Mass Assembly (GAMA): Self-Organizing Map Application on Nearby Galaxies

Galaxy populations show bimodality in a variety of properties: stellar mass, colour, specific star-formation rate, size, and S\'ersic index. These parameters are our feature space. We use an existing sample of 7556 galaxies from the Galaxy and Mass Assembly (GAMA) survey, represented using five features and the K-means clustering technique, showed that the bimodalities are the manifestation of a more complex population structure, represented by between 2 and 6 clusters. Here we use Self Organizing Maps (SOM), an unsupervised learning technique which can be used to visualize similarity in a higher dimensional space using a 2D representation, to map these five-dimensional clusters in the feature space onto two-dimensional projections. To further analyze these clusters, using the SOM information, we agree with previous results that the sub-populations found in the feature space can be reasonably mapped onto three or five clusters. We explore where the "green valley" galaxies are mapped onto the SOM, indicating multiple interstitial populations within the green valley population. Finally, we use the projection of the SOM to verify whether morphological information provided by GalaxyZoo users, for example, if features are visible, can be mapped onto the SOM-generated map. Voting on whether galaxies are smooth, likely ellipticals, or "featured" can reasonably be separated but smaller morphological features (bar, spiral arms) can not. SOMs promise to be a useful tool to map and identify instructive sub-populations in multidimensional galaxy survey feature space, provided they are large enough.Comment: 14 pages, 14 figures, accepted by MNRA

Galaxy and mass assembly (GAMA): Self-Organizing Map application on nearby galaxies

Galaxy populations show bimodality in a variety of properties: stellar mass, colour, specific star-formation rate, size, and Sérsic index. These parameters are our feature space. We use an existing sample of 7556 galaxies from the Galaxy and Mass Assembly (GAMA) survey, represented using five features and the K-means clustering technique, showed that the bimodalities are the manifestation of a more complex population structure, represented by between two and six clusters. Here we use Self-Organizing Maps (SOM), an unsupervised learning technique that can be used to visualize similarity in a higher dimensional space using a 2D representation, to map these 5D clusters in the feature space on to 2D projections. To further analyse these clusters, using the SOM information, we agree with previous results that the sub-populations found in the feature space can be reasonably mapped on to three or five clusters. We explore where the ‘green valley’ galaxies are mapped on to the SOM, indicating multiple interstitial populations within the green valley population. Finally, we use the projection of the SOM to verify whether morphological information provided by GalaxyZoo users, for example, if features are visible, can be mapped on to the SOM-generated map. Voting on whether galaxies are smooth, likely ellipticals, or ‘featured’ can reasonably be separated but smaller morphological features (bar, spiral arms) can not. SOMs promise to be a useful tool to map and identify instructive sub-populations in multidimensional galaxy survey feature space, provided they are large enough