Transitivity of the climate–vegetation system in a warm climate

To date, the transitivity of the global system has been analysed for late Quaternary (glacial, interglacial, and present-day) climate. Here, we extend this analysis to a warm, almost ice-free climate with a different configuration of continents. We use the Earth system model of the Max Planck Institute for Meteorology to analyse the stability of the climate system under early Eocene and pre-industrial conditions. We initialize the simulations by prescribing either dense forests or bare deserts on all continents. Starting with desert continents, an extended desert remains in central Asia in the early Eocene climate. Starting with dense forest coverage, the Asian desert is much smaller, while coastal deserts develop in the Americas which appear to be larger than in the simulations with initially bare continents. These differences can be attributed to differences in the large-scale tropical circulation. With initially forested continents, a stronger dipole in the 200 hPa velocity potential develops than in the simulation with initially bare continents. This difference prevails when vegetation is allowed to adjust to and interact with climate. Further simulations with initial surface conditions that differ in the region of the Asian desert only indicate that local feedback processes are less important in the development of multiple states. In the interglacial, pre-industrial climate, multiple states develop only in the Sahel region. There, local climate–vegetation interaction seems to dominate

The influence of vegetation dynamics on anthropogenic climate change

In this study, vegetation–climate and vegetation–carbon cycle interactions during anthropogenic climate change are assessed by using the Earth System Model of the Max Planck Institute for Meteorology (MPI ESM) that includes vegetation dynamics and an interactive carbon cycle. We assume anthropogenic CO<sub>2</sub> emissions according to the RCP 8.5 scenario in the time period from 1850 to 2120. For the time after 2120, we assume zero emissions to evaluate the response of the stabilising Earth System by 2300. <br><br> Our results suggest that vegetation dynamics have a considerable influence on the changing global and regional climate. In the simulations, global mean tree cover extends by 2300 due to increased atmospheric CO<sub>2</sub> concentration and global warming. Thus, land carbon uptake is higher and atmospheric CO<sub>2</sub> concentration is lower by about 40 ppm when considering dynamic vegetation compared to the static pre-industrial vegetation cover. The reduced atmospheric CO<sub>2</sub> concentration is equivalent to a lower global mean temperature. Moreover, biogeophysical effects of vegetation cover shifts influence the climate on a regional scale. Expanded tree cover in the northern high latitudes results in a reduced albedo and additional warming. In the Amazon region, declined tree cover causes a regional warming due to reduced evapotranspiration. As a net effect, vegetation dynamics have a slight attenuating effect on global climate change as the global climate cools by 0.22 K due to natural vegetation cover shifts in 2300

Radiative forcing by forest and subsequent feedbacks in the early Eocene climate

Using the Max Planck Institute for Meteorology Earth System Model, we investigate the forcing of forests and the feedback triggered by forests in the pre-industrial climate and in the early Eocene climate (about 54 to 52 million years ago). Other than the interglacial, pre-industrial climate, the early Eocene climate was characterised by high temperatures which led to almost ice-free poles. We compare simulations in which all continents are covered either by dense forest or by bare soil. To isolate the effect of soil albedo, we choose either bright soils or dark soils, respectively. Considering bright soil, forests warm in both, the early Eocene climate and the current climate, but the warming differs due to differences in climate feedbacks. The lapse-rate and water-vapour feedback is stronger in early Eocene climate than in current climate, but strong and negative cloud feedbacks and cloud masking in the early Eocene climate outweigh the stronger positive lapse-rate and water-vapour feedback. In the sum, global mean warming is weaker in the early Eocene climate. Sea-ice related feedbacks are weak in the almost ice-free climate of the early Eocene leading to a weak polar amplification. Considering dark soil, our results change. Forests cools stronger in the early Eocene climate than in the current climate because the lapse-rate and water-vapour feedback is stronger in the early Eocene climate while cloud feedbacks and cloud masking are equally strong in both climates. The different temperature change by forest in both climates highlights the state-dependency of vegetation's impact on climate

Dual fluorescence of 9-anthryl-substituted oligothiophenes in nonpolar environment

9-Anthryl-oligothiophenes (9A-Tn, n = 1–4) have been studied in n-hexane solution between helium and room temperature using absorption, fluorescence emission and excitation spectra and time resolved fluorescence measurements. These compounds are reference systems for studies on intramolecular energy and charge transfer in donor/acceptor-substituted conjugated chain molecules. The absorption spectra show contribution of both substituents anthracene and oligothiophene, but no additional bands due to mixed electronic states. Dual fluorescence is observed at Tgreater-or-equal, slanted 120 K for the compounds 9A-Tn (n = 1–3), but not for 9A-T4. Time resolved spectroscopy reveals a dynamical coupling between the two emission components whose relative quantum yields are strongly temperature dependent. The occurrence of the dual fluorescence is explained by an intramolecular torsional motion between the two molecular subunits

Albumin Microspheres as “Trans-ferry-beads” for Easy Cell Passaging in Cell Culture Technology

Protein hydrogels represent ideal materials for advanced cell culture applications, including 3D-cultivation of even fastidious cells. Key properties of fully functional and, at the same time, economically successful cell culture materials are excellent biocompatibility and advanced fabrication processes allowing their easy production even on a large scale based on affordable compounds. Chemical crosslinking of bovine serum albumin (BSA) with N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (EDC) in a water-in-oil emulsion with isoparaffinic oil as the continuous phase and sorbitan monooleate as surfactant generates micro-meter-scale spherical particles. They allow a significant simplification of an indispensable and laborious step in traditional cell culture workflows. This cell passaging (or splitting) to fresh culture vessels/flasks conventionally requires harsh trypsinization, which can be omitted by using the “trans-ferry-beads” presented here. When added to different pre-cultivated adherent cell lines, the beads are efficiently boarded by cells as passengers and can be easily transferred afterward for the embarkment of novel flasks. After this procedure, cells are perfectly viable and show normal growth behavior. Thus, the trans-ferry-beads not only may become extremely affordable as a final product but also may generally replace trypsinization in conventional cell culture, thereby opening new routes for the establishment of optimized and resource-efficient workflows in biological and medical cell culture laboratories

Intravenous C.E.R.A. maintains stable haemoglobin levels in patients on dialysis previously treated with darbepoetin alfa: results from STRIATA, a randomized phase III study

Background. Extending the administration interval of erythropoiesis-stimulating agents (ESAs) represents an opportunity to improve the efficiency of anaemia management in patients with chronic kidney disease (CKD). However, effective haemoglobin (Hb) maintenance can be challenging with epoetin alfa and epoetin beta administered at extended intervals. C.E.R.A., a continuous erythropoietin receptor activator, has a unique pharmacologic profile and long half-life (∼130 h), allowing administration at extended intervals. Phase III results have demonstrated that C.E.R.A. administered once every 4 weeks effectively maintains stable Hb levels in patients with CKD on dialysis

Dimension of interaction dynamics

A method allowing to distinguish interacting from non-interacting systems based on available time series is proposed and investigated. Some facts concerning generalized Renyi dimensions that form the basis of our method are proved. We show that one can find the dimension of the part of the attractor of the system connected with interaction between its parts. We use our method to distinguish interacting from non-interacting systems on the examples of logistic and H\'enon maps. A classification of all possible interaction schemes is given.Comment: 15 pages, 14 (36) figures, submitted to PR

A neural oscillations perspective on phonological development and phonological processing in developmental dyslexia

Children’s ability to reflect upon and manipulate the sounds in words (’phonological awareness’) develops as part of natural language acquisition, supports reading acquisition, and develops further as reading and spelling are learned. Children with developmental dyslexia typically have impairments in phonological awareness. Many developmental factors contribute to individual differences in phonological development. One important source of individual differences may be the child’s sensory/neural processing of the speech signal from an amplitude modulation (~ energy or intensity variation) perspective, which may affect the quality of the sensory/neural representations (’phonological representations’) that support phonological awareness. During speech encoding, brain electrical rhythms (oscillations, rhythmic variations in neural excitability) re-calibrate their temporal activity to be in time with rhythmic energy variations in the speech signal. The accuracy of this neural alignment or ’entrainment’ process is related to speech intelligibility. Recent neural studies demonstrate atypical oscillatory function at slower rates in children with developmental dyslexia. Potential relations with the development of phonological awareness by children with dyslexia are discussed.Medical Research Council, G0400574 and G090237

Sensory theories of developmental dyslexia: three challenges for research.

Recent years have seen the publication of a range of new theories suggesting that the basis of dyslexia might be sensory dysfunction. In this Opinion article, the evidence for and against several prominent sensory theories of dyslexia is closely scrutinized. Contrary to the causal claims being made, my analysis suggests that many proposed sensory deficits might result from the effects of reduced reading experience on the dyslexic brain. I therefore suggest that longitudinal studies of sensory processing, beginning in infancy, are required to successfully identify the neural basis of developmental dyslexia. Such studies could have a powerful impact on remediation.This is the accepted manuscript. The final version is available from NPG at http://www.nature.com/nrn/journal/v16/n1/abs/nrn3836.html

Axillary sentinel lymph node biopsy after mastectomy: a case report

<p>Abstract</p> <p>Background</p> <p>Sentinel lymph node biopsy has been established as the preferred method for staging early breast cancer. A prior history of mastectomy is felt to be a contraindication.</p> <p>Case presentation</p> <p>A patient with recurrent breast cancer in her skin flap was discovered to have positive axillary sentinel nodes by sentinel lymph node biopsy five years after mastectomy for ductal carcinoma in situ.</p> <p>Conclusion</p> <p>A prior history of mastectomy may not be an absolute contraindication to sentinel lymph node biopsy.</p