60 research outputs found
Characteristics of Vehicular Traffic Flow at a Roundabout
We construct a stochastic cellular automata model for the description of
vehicular traffic at a roundabout designed at the intersection of two
perpendicular streets. The vehicular traffic is controlled by a self-organized
scheme in which traffic lights are absent. This controlling method incorporates
a yield-at-entry strategy for the approaching vehicles to the circulating
traffic flow in the roundabout. Vehicular dynamics is simulated within the
framework of the probabilistic cellular automata and the delay experienced by
the traffic at each individual street is evaluated for specified time
intervals. We discuss the impact of the geometrical properties of the
roundabout on the total delay. We compare our results with traffic-light
signalisation schemes, and obtain the critical traffic volume over which the
intersection is optimally controlled through traffic light signalisation
schemes.Comment: 10 pages, 17 eps figures. arXiv admin note: text overlap with
arXiv:cond-mat/040107
Optimised Traffic Flow at a Single Intersection: Traffic Responsive signalisation
We propose a stochastic model for the intersection of two urban streets. The
vehicular traffic at the intersection is controlled by a set of traffic lights
which can be operated subject to fix-time as well as traffic adaptive schemes.
Vehicular dynamics is simulated within the framework of the probabilistic
cellular automata and the delay experienced by the traffic at each individual
street is evaluated for specified time intervals. Minimising the total delay of
both streets gives rise to the optimum signalisation of traffic lights. We
propose some traffic responsive signalisation algorithms which are based on the
concept of cut-off queue length and cut-off density.Comment: 10 pages, 11 eps figs, to appear in J. Phys.
Malaysian primary care doctors' views on men's health: an unresolved jigsaw puzzle
<p>Abstract</p> <p>Background</p> <p>Men have been noted to utilise health care services less readily then women. Primary care settings provide an opportunity to engage men in health care activities because of close proximity to the target group (men in the community). Understanding attitudes towards men's health among Malaysian primary care doctors is important for the effective delivery of health services to men. We aimed to explore the opinions and attitudes of primary care doctors (PCDs) relating to men's health and help-seeking behaviour.</p> <p>Methods</p> <p>A qualitative approach to explore the opinions of 52 PCDs was employed, using fourteen in-depth interviews and eight focus group discussions in public and private settings. Purposive sampling of PCDs was done to ensure maximum variation in the PCD sample. Interviews were recorded and transcribed verbatim for analysis. Open coding with thematic analysis was used to identify key issues raised in the interview.</p> <p>Results</p> <p>The understanding of the concept of men's health among PCDs was fragmented. Although many PCDs were already managing health conditions relevant and common to men, they were not viewed by PCDs as "men's health". Less attention was paid to men's help-seeking behaviour and their gender roles as a potential determinant of the poor health status of men. There were opposing views about whether men's health should focus on men's <it>overall </it>health or a more focused approach to sexual health. There was also disagreement about whether special attention was warranted for men's health services. Some doctors would prioritise more common conditions such as hypertension, diabetes and hypercholesterolaemia.</p> <p>Conclusions</p> <p>The concept of men's health was new to PCDs in Malaysia. There was wide variation in understanding and opposing attitudes towards men's health among primary care doctors. Creating awareness and having a systematic approach would facilitate PCDs in delivering health service to men.</p
Self-Control of Traffic Lights and Vehicle Flows in Urban Road Networks
Based on fluid-dynamic and many-particle (car-following) simulations of
traffic flows in (urban) networks, we study the problem of coordinating
incompatible traffic flows at intersections. Inspired by the observation of
self-organized oscillations of pedestrian flows at bottlenecks [D. Helbing and
P. Moln\'ar, Phys. Eev. E 51 (1995) 4282--4286], we propose a self-organization
approach to traffic light control. The problem can be treated as multi-agent
problem with interactions between vehicles and traffic lights. Specifically,
our approach assumes a priority-based control of traffic lights by the vehicle
flows themselves, taking into account short-sighted anticipation of vehicle
flows and platoons. The considered local interactions lead to emergent
coordination patterns such as ``green waves'' and achieve an efficient,
decentralized traffic light control. While the proposed self-control adapts
flexibly to local flow conditions and often leads to non-cyclical switching
patterns with changing service sequences of different traffic flows, an almost
periodic service may evolve under certain conditions and suggests the existence
of a spontaneous synchronization of traffic lights despite the varying delays
due to variable vehicle queues and travel times. The self-organized traffic
light control is based on an optimization and a stabilization rule, each of
which performs poorly at high utilizations of the road network, while their
proper combination reaches a superior performance. The result is a considerable
reduction not only in the average travel times, but also of their variation.
Similar control approaches could be applied to the coordination of logistic and
production processes
The role of inflammation in epilepsy.
Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring predisposition to generate seizures. Despite progress in pharmacological and surgical treatments of epilepsy, relatively little is known about the processes leading to the generation of individual seizures, and about the mechanisms whereby a healthy brain is rendered epileptic. These gaps in our knowledge hamper the development of better preventive treatments and cures for the approximately 30% of epilepsy cases that prove resistant to current therapies. Here, we focus on the rapidly growing body of evidence that supports the involvement of inflammatory mediators-released by brain cells and peripheral immune cells-in both the origin of individual seizures and the epileptogenic process. We first describe aspects of brain inflammation and immunity, before exploring the evidence from clinical and experimental studies for a relationship between inflammation and epilepsy. Subsequently, we discuss how seizures cause inflammation, and whether such inflammation, in turn, influences the occurrence and severity of seizures, and seizure-related neuronal death. Further insight into the complex role of inflammation in the generation and exacerbation of epilepsy should yield new molecular targets for the design of antiepileptic drugs, which might not only inhibit the symptoms of this disorder, but also prevent or abrogate disease pathogenesis
Astrocytes: biology and pathology
Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS. Astrocytes respond to all forms of CNS insults through a process referred to as reactive astrogliosis, which has become a pathological hallmark of CNS structural lesions. Substantial progress has been made recently in determining functions and mechanisms of reactive astrogliosis and in identifying roles of astrocytes in CNS disorders and pathologies. A vast molecular arsenal at the disposal of reactive astrocytes is being defined. Transgenic mouse models are dissecting specific aspects of reactive astrocytosis and glial scar formation in vivo. Astrocyte involvement in specific clinicopathological entities is being defined. It is now clear that reactive astrogliosis is not a simple all-or-none phenomenon but is a finely gradated continuum of changes that occur in context-dependent manners regulated by specific signaling events. These changes range from reversible alterations in gene expression and cell hypertrophy with preservation of cellular domains and tissue structure, to long-lasting scar formation with rearrangement of tissue structure. Increasing evidence points towards the potential of reactive astrogliosis to play either primary or contributing roles in CNS disorders via loss of normal astrocyte functions or gain of abnormal effects. This article reviews (1) astrocyte functions in healthy CNS, (2) mechanisms and functions of reactive astrogliosis and glial scar formation, and (3) ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions
The downward spiral of mental disorders and educational attainment: a systematic review on early school leaving.
BACKGROUND: Most psychiatric disorders present symptom patterns that cause severe impairment on the emotional, cognitive and social level. Thus, adolescents who suffer from a mental disorder risk finding themselves in a downward spiral caused by the reciprocal association of psychological symptoms and negative school experiences that may culminate in early school leaving. In addition to previous collective work that mainly focused on school refusing behaviour among children and was presented as an expert's opinion, the following systematic review fills the knowledge gap by providing a structured overview of the bidirectional association between mental health and secondary school dropout based on a sound methodology and with a particular focus on mediating factors. METHODS: Four electronic databases were searched from January 1990 until June 2014. Selected references were assessed for study details, main results, mediating factors and methodological limitations. Standardized risk of bias assessment was conducted. RESULTS: Mood and anxiety disorders seemed to have a less consequential direct effect on early school leaving than substance use and disruptive behaviour disorders. The association between externalizing disorders and educational attainment was even stronger when the disorder occurred early in life. On the other hand, internalizing disorders were reported to develop as a consequence of school dropout. Only few studies had addressed gender differences, with discrepant results. Socio-economic background, academic achievement and family support were identified as significant mediating factors of the association between mental disorders and subsequent educational attainment. CONCLUSIONS: Findings suggested a strong association between mental health and education, in both directions. However, most studies focused on mediating factors that could not be targeted by intervention programs
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