Effect of mebendazole on fibrosarcoma in hamsters

Purpose: To investigate the effect of mebendazole on an in vivo solid tumor model of fibrosarcoma in hamsters.Methods: 24 Syrian golden hamsters of both sexes with the approximate body  weight of 100g were randomly distributed in 2 experimental and 2 control groups, with 6 animals in each group. BHK-21/C13 cells (2 x 106) in 1 mL Glasgow Minimum Essential Medium (GMEM) were injected subcutaneously into the back of each animal in 3 groups. The experimental groups were treated with mebendazole  (460 mg/kg) via a gastric tube on a daily basis, immediately after tumor inoculation. In addition, one experimental group received deoxycholic acid 20 mg/kg once a day. After 2 weeks, when the tumors were approximately 1 - 2 cm in the control group, all the animals were sacrificed, and their blood collected for laboratory analysis. The tumors were excised, their weight and diameters measured, and the volumes  calculated. The tumor samples were histopathologically assessed and the main organs toxicologically analyzed. Images were taken and processed by an imaging software, and Ki-67-positive cells in the tumor samples were quantified.Results: Mebendazole diminished tumor mitosis from 18.5 ± 3.02 to 13.5 ± 3.45 (p < 0.05), vasculature and tissue penetration, and increased necroses in tumor  slices. Tumor volume and weight were insignificantly attenuated. Toxicity was not observed.Conclusion: Mebendazole might be an effective non-toxic agent in sarcoma therapy.Keywords: Mebendazole, Hamsters, BHK-21/C13 cells, Fibrosarcoma therapy,  Tumor mitosi

Application of a widely-used tropical anti-worm agent, mebendazole, in modern oncology

Although clinical trials have not been completed, it has already been confirmed that mebendazole, a well-known anti-parasitic drug widely used in the tropical areas, inhibits cancer cell growth. Preclinical studies show that mebendazole notably impedes the growth of malignant and metastatic tumors such as osteosarcoma and soft tissue sarcoma, melanoma, carcinoma (lung, colorectal, breast, ovarian, hepatocellular and adrenocortical), acute myeloid leukaemia, glioblastoma multiforme and  meduloblastoma. Mebendazole can induce the depolymerization of microtubules in neoplasms and newly formed vasculature, stopping tumor growth and neoangiogenesis, along with other proposed mechanisms of action.Keywords: Anthelmintic, Mebendazole, Cancer treatment, Antimicrotubullar effect, Antineoangiogenesi

Interactive Design of Rigid-Body Simulation for Computer Animation

as representing the official policies, either expressed or implied, of the NSF, Microsoft, Siebel Systems or th

Example-Based Control of Human Motion

In human motion control applications, the mapping between a control specification and an appropriate target motion often defies an explicit encoding. We present a method that allows such a mapping to be defined by example, given that the control specification is recorded motion. Our method begins by building a database of semantically meaningful instances of the mapping, each of which is represented by synchronized segments of control and target motion. A dynamic programming algorithm can then be used to interpret an input control specification in terms of mapping instances. This interpretation induces a sequence of target segments from the database, which is concatenated to create the appropriate target motion. We evaluate our method on two examples of indirect control. In the first, we synthesize a walking human character that follows a sampled trajectory. In the second, we generate a synthetic partner for a dancer whose motion is acquired through motion capture. Categories and Subject Descriptors (according to ACM CCS): I.3.7 [Computer Graphics]: Animation 1

Computing the Physical Parameters of Rigid-body

This paper presents an optimization framework for estimating the motion and underlying physical parameters of a rigid body in free flight from video

Characterization of poly(vinyl alcohol)/gold nanocomposites obtained by in situ gamma-irradiation method

Gamma-irradiation induced reduction of gold (Au) ions was performed in aqueous poly(vinyl alcohol) (PVA) solution. PVA/Au nanocomposites with different contents of inorganic phase were prepared by solvent evaporation. The colloids and corresponding nanocomposites show visible light absorption with strong excitonic peak in the wavelength range from 520 to 550 nm. Morphological and structural characterizations of gold nanoparticles (Au NPs) and nanocomposites were performed by TEM, XRD, and FTIR measurements. Also, Mie and Maxwell-Garnett theories were applied to calculate optical properties of Au colloids and PVA/Au nanocomposites, respectively. The changes of heat resistance upon the increase of inorganic phase were correlated to the decrease in crystal perfection of polymer. Improvement of thermal stability of nanocomposites, compared with the neat PVA, was observed when the content of inorganic phase exceeds 1 wt %. (c) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 201

Poly(dialkoxyethyl itaconate)s-I. Some properties of dimethoxyethyl itaconate and its polymer

The preparation of dimethoxyethyl itaconate and its polymerisation are described. Some of the properties of the monomer and polymer were determined with special emphasis on the experimental determination of the solubility parameter of the polymer, δp. Possible reasons for the relatively high experimentally determined value of δp 21.6 (J/cm3)1 2 are discussed with comparison to calculated and experimentally determined values for poly(di-butyl itaconate)

GENERALIZED DERIVATIVES AND EXPANSIONS

Style translation is the process of transforming an input motion into a new style while preserving its original content. This problem is motivated by the needs of interactive applications, which require rapid processing of captured performances. Our solution learns to translate by analyzing differences between performances of the same content in input and output styles. It relies on a novel correspondence algorithm to align motions, and a linear time-invariant model to represent stylistic differences. Once the model is estimated with system identification, our system is capable of translating streaming input with simple linear operations at each frame