Diseño, comprobación estructual y propuestas de mejora de una bicicleta para su uso sobre la nieve

[ES] Diseñar y comprobar estructuralmente un modelo de bicicleta para su uso sobre la nieve, proponiendo un aspecto atractivo e innovador teniendo en cuenta su ergonomía. Estudiar cada uno de los componentes que conforman la bicicleta y comprobar su correcta funcionalidad y resistencia. Uno de los objetivos principales es analizar la viabilidad del producto y definir el proceso de construcción del mismo.[EN] This project aims to create a versatile mountain bike and be able to adapt to terrain and surfaces which cyclists always have considered complicated like it a snowy mountain. This is why it has been designed a bicycle frame with dimensions and angles that make it capable of adapting to any type of route and a complement that you provide the ability to slither over the snow efficiently and securely. Based on a study of the demands that must comply with the bike, has chosen to make a bicycle with an electric motor and a built-in battery to give a different product and with a care design. Thanks to the set of all these features, is offers a product that the cyclist will be whoever puts the limit and that you will enjoy your hobby and tackle any journey without fear and focusing only on reach as far and as high as he can.Ponsoda Acedo, J. (2017). Diseño, comprobación estructual y propuestas de mejora de una bicicleta para su uso sobre la nieve. http://hdl.handle.net/10251/96662TFG

Caracterización y simulación del comportamiento viscoelástico de materiales plásticos mediante el Método de Elementos Finitos

Ponsoda Acedo, J. (2019). Caracterización y simulación del comportamiento viscoelástico de materiales plásticos mediante el Método de Elementos Finitos. http://hdl.handle.net/10251/129510TFG

Pterostilbene-Induced Tumor Cytotoxicity: A Lysosomal Membrane Permeabilization-Dependent Mechanism

The phenolic phytoalexin resveratrol is well known for its health-promoting and anticancer properties. Its potential benefits are, however, limited due to its low bioavailability. Pterostilbene, a natural dimethoxylated analog of resveratrol, presents higher anticancer activity than resveratrol. The mechanisms by which this polyphenol acts against cancer cells are, however, unclear. Here, we show that pterostilbene effectively inhibits cancer cell growth and stimulates apoptosis and autophagosome accumulation in cancer cells of various origins. However, these mechanisms are not determinant in cell demise. Pterostilbene promotes cancer cell death via a mechanism involving lysosomal membrane permeabilization. Different grades of susceptibility were observed among the different cancer cells depending on their lysosomal heat shock protein 70 (HSP70) content, a known stabilizer of lysosomal membranes. A375 melanoma and A549 lung cancer cells with low levels of HSP70 showed high susceptibility to pterostilbene, whereas HT29 colon and MCF7 breast cancer cells with higher levels of HSP70 were more resistant. Inhibition of HSP70 expression increased susceptibility of HT29 colon and MCF7 breast cancer cells to pterostilbene. Our data indicate that lysosomal membrane permeabilization is the main cell death pathway triggered by pterostilbene.Mena Llido, S.; Rodriguez, ML.; Ponsoda Acedo, J.; Estrela, JM.; Jaattela, M.; Ortega, ÁL. (2012). Pterostilbene-Induced Tumor Cytotoxicity: A Lysosomal Membrane Permeabilization-Dependent Mechanism. PLoS ONE. 7(9):1-12. doi:10.1371/journal.pone.0044524S1127