ПОВЫШЕНИЕ ТОЧНОСТИ И РАСШИРЕНИЕ ФУНКЦИОНАЛЬНЫХ ВОЗМОЖНОСТЕЙ ЦИФРОВЫХ ФИЛЬТРОВ НА ОСНОВЕ ЧАСТОТНОЙ ВЫБОРКИ

The  method  of  expansion  of  set  of  analyzing  frequencies  with  digital  filters,  based  on  frequency selection, was suggested. The way of increasing of measurement precision using this class of filters was investigated.  The  conformal  generalization  of  structure  of  filters  based  on  frequency  selection  and  the standard nonrecursive comb filter are the base of this method. This method can be used in different fields of research where the task of determination of hide periodicities is actual.Предложен метод расширения множества анализируемых частот цифровыми фильтрами на основе частотной выборки. Рассмотрен способ повышения точности измерения этим классом фильтров спектров сигналов. В основе предложенного подхода лежит согласованное обобщение структур фильтров на основе частотной выборки и стандартного нерекурсивного гребенчатого фильтра. Предложенный метод может найти широкое применение при решении задач выявления скрытых периодичностей

To question the quality of higher education

In the period of formation of new requirements to the system of higher education related to the digital economy, it is necessary to take a fresh look at the problem of the quality of Russian higher education. The quality of education each of its participants (state, society, institution of higher education, the individual) has its own requirements. The most popular audience of education are students of higher education institutions, so it is important to identify their opinion about the current state of higher education.В период формирования новых требований к системе высшего образования, связанных с цифровой экономикой, необходимо по-новому взглянуть на проблему качества российского высшего образования. К качеству образования каждый из его участников (государство, общество, учреждение высшего образования, индивид) предъявляет свои требования. К наиболее массовой аудитории образования относятся студенты учреждений высшего образования, поэтому так важно выявить их мнение о современном состоянии высшего образования

Positively Correlated miRNA-miRNA Regulatory Networks in Mouse Frontal Cortex During Early Stages of Alcohol Dependence

Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind. MicroRNAs simultaneously target many transcripts and fine-tune the expression of genes through cooperative/combinatorial targeting. Therefore, they have a large regulatory potential that could widely impact development and progression of diseases, as well as contribute unpredicted collateral effects due to their natural, pathophysiological, or treatment-induced modulation. We support the viewpoint that whole mirnome-transcriptome interaction analysis is required to better understand the mechanisms and potential consequences of miRNA regulation and/or deregulation in relevant biological models. In this study, we tested the hypotheses that ethanol consumption induces changes in miRNA-mRNA interaction networks in the mouse frontal cortex and that some of the changes observed in the mouse are equivalent to changes in similar brain regions from human alcoholics. Results: miRNA-mRNA interaction networks responding to ethanol insult were identified by differential expression analysis and weighted gene coexpression network analysis (WGCNA). Important pathways (coexpressed modular networks detected by WGCNA) and hub genes central to the neuronal response to ethanol are highlighted, as well as key miRNAs that regulate these processes and therefore represent potential therapeutic targets for treating alcohol addiction. Importantly, we discovered a conserved signature of changing miRNAs between ethanol-treated mice and human alcoholics, which provides a valuable tool for future biomarker/diagnostic studies in humans. We report positively correlated miRNA-mRNA expression networks that suggest an adaptive, targeted miRNA response due to binge ethanol drinking. Conclusions: This study provides new evidence for the role of miRNA regulation in brain homeostasis and sheds new light on current understanding of the development of alcohol dependence. To our knowledge this is the first report that activated expression of miRNAs correlates with activated expression of mRNAs rather than with mRNA downregulation in an in vivo model. We speculate that early activation of miRNAs designed to limit the effects of alcohol-induced genes may be an essential adaptive response during disease progression.NIAAA 5R01AA012404, 5P20AA017838, 5U01AA013520, P01AA020683, 5T32AA007471-24/25Waggoner Center for Alcohol and Addiction Researc

Features of personal data protection in medicine

Digital technologies are actively penetrating all sectors of the national economy, including medicine. Active computerization of the industry is carried out in the field of diagnostics of diseases, surgical operations, office work, storage of medical information, and more. All this together leads to an increase in the number of leaks of personal information from medical institutions of various types and forms of ownership. In such circumstances, the issue of personal data protection in medicine becomes relevantЦифровые технологии активно проникают во все отрасли народного хозяйства, включая медицину. Активная компьютеризация отрасли осуществляется в области диагностики заболеваний, делопроизводства, хранения медицинской информации и т.д. Все это в совокупности влечет повышение количества утечек персональной информации из медицинских учреждений различного типа и форм собственности. В таких обстоятельствах актуализируется вопрос защиты персональных данных в медицин

Comparative analysis of neurosurgical operations on the brain in Russia and Germany

The article presents a comparative analysis of the cost of two types of neurosurgical operations performed in medical institutions in Russia and Germany. The analysis was carried out on the following parameters: the cost of the operation, including the anesthetic allowance, hospital stay, the cost of necessary research, stay in the intensive care unit.В статье представлен сравнительный анализ стоимости двух видов нейрохирургических операций, проводимых в медицинских учреждениях России и Германии. Анализ проведен по следующим параметрам: стоимость операции, включая анестезиологическое пособие, пребывание в стационаре, стоимость необходимых исследований, пребывание в отделении реанимации и интенсивной терапии

Analysis of the pharmaceutical market of the period 2012-2019 year

The article provides a statistical analysis of the development of the pharmaceutical market of Russia for the period 2012-2019. The analysis aims to identify trends in the pharmaceutical market in 2020 and subsequent periods.В статье проведен статистический анализ развития фармацевтического рынка России за период 2012-2019 гг. Анализ направлен на выявление тенденций фармацевтического рынка в 2020 г. и последующие периоды

The article considers the economic phenomenon of MMM as an organization And S. p. Mavrodi, whose personality, as well as his activities, still cause extremely ambiguous assessments.

The article considers the economic phenomenon of MMM as an organization And S. p. Mavrodi, whose personality, as well as his activities, still cause extremely ambiguous assessments.В статье рассмотрен экономический феномен МММ как организации и С. П. Мавроди, личность которого, как и его деятельность, до сих пор вызывают крайне неоднозначные оценки

Business - plan the medical clinic "Osteopathy" in Verkhnyaya Pyshma

A marketing study was Conducted to develop a business plan of the medical clinic "Osteopathy" in the city of Verkhnyaya Pyshma. Economic calculations to assess the profitability of the project.Проведено маркетинговое исследование с целью разработки бизнес-плана медицинской клиники "Остеопатия" в городе Верхняя Пышма. Проведены экономические расчеты по оценке рентабельности проекта

Characteristic of life style and medical care in Czech Republic

The article deals with the main aspects of life in the Czech Republic such as: features of employment, pension, diploma, rental housing, health care, including health insurance, call an ambulance and purchase of medicines.В статье рассмотрены основные аспекты жизни в Чехии такие, как: особенности трудоустройства, получение пенсии, подтверждение диплома, аренда жилья, медицинского обслуживания, включая медицинское страхование, вызов скорой помощи и покупка лекарственных препаратов

Analysis of the market of cosmetology services in Yekaterinburg

The article analyzes the market of cosmetic services in the city of Yekaterinburg to identify the most common.В статье проведен анализ рынка косметологических услуг в городе Екатеринбург для выявления наиболее распространенных