8 research outputs found
Sharing Social Pain: Social Comparison and Affiliation After Social Exclusion
- Author
- Publication venue
- W&M ScholarWorks
- Publication date
- 01/01/2008
- Field of study
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
- Author
- Aanensen David M.
- Abraham Priyanka
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Adele Sandra
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Ansari M. Azim
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Asamaphan Patawee
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Ashraf Shirin
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Austin James
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barnes Eleanor
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Anthony
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Cantoni Diego
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cowton Vanessa
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R.
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- Cutino-Moguel Teresa
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Chris
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- De Lorenzo Giuditta
- de Oliveira Martins Leonardo
- de Silva Thushan
- de Silva Thushan I.
- Debebe Johnny
- Deeks Alexandra
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Dunachie Susanna
- Dunachie Susanna
- Duncan Christopher
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J.
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Everson William
- Fairley Derek J.
- Fallon Karlie
- Fanaie Arezou
- Farr Ben W.
- Fearn Christopher
- Feltwell Theresa
- Ferguson Lynne
- Fina Laia
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Furnon Wilhelm
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia T.
- Glaysher Sharon
- Goldstein Emily J.
- Golubchik Tanya
- Gomes Andrea N.
- Gonçalves Sónia
- Goodfellow Ian G.
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R.
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Grove Joe
- Guest Martyn
- Gunson Rory
- Gunson Rory N.
- Gupta Ravi K.
- Gutierrez Bernardo
- Haldenby Sam T.
- Hamilton William L.
- Hansford Samantha E.
- Haque Tanzina
- Harris Kathryn A.
- Harrison Ewan M.
- Harrison Ian
- Hart Jennifer
- Hartley John A.
- Harvey Matthew
- Harvey William T.
- Harvey William T.
- Hassan-Ibrahim Mohammed O.
- Haughney John
- Heaney Judith
- Helmer Thomas
- Henderson John H.
- Hesketh Andrew R.
- Hey Jessica
- Heyburn David
- Higginson Ellen E.
- Hill Jack D.
- Hill Verity
- Hilson Rachel A.
- Hilvers Ember
- Holden Matthew T. G.
- Holden Matthew T. G.
- Holland Poppy
- Hollis Amy
- Holmes Alison H.
- Holmes Christopher W.
- Holmes Nadine
- Hopes Richard
- Hornsby Hailey R.
- Hosmillo Myra
- Houlihan Catherine
- Howson-Wells Hannah C.
- Hsu Sharon N.
- Hubb Jonathan
- Huckson Hannah
- Hughes Joseph
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Ben
- Jackson Chris
- Jackson David K.
- Jackson Kathryn A.
- Jackson Leigh M.
- Jahun Aminu S.
- James Keith
- James Victoria
- Jeanes Christopher
- Jeffries Aaron R.
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R.
- Jones Hannah
- Jones Neil
- Jones Owen
- Jones Sophie
- Joseph Amelia
- Judges Sarah
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kele Beatrix
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Kidd Stephen P.
- Killough Nicholas F.
- Kimuli Maimuna
- Kirk Stuart
- Kitchen Christine
- Kitchman Katie
- Klenerman Paul
- Klenerman Paul
- Knight Bridget A.
- Koshy Cherian
- Kraemer Moritz U. G.
- Kronsteiner Barbara
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G.
- Lampejo Temi
- Langford Cordelia F.
- Lavin Deborah
- Lawton Andrew I.
- Le-Viet Thanh
- Lee David
- Lee Jack C. D.
- Lensing Stefanie V.
- Leonard Steven
- Levett Lisa J.
- Lewis Jonathan
- Lewis Kevin
- Liddle Jennifier
- Liggett Steven
- Lillie Patrick J.
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lo Stephanie
- Logan Nicola
- Loman Nicholas J.
- Loose Matthew W.
- Louka Stavroula F.
- Loveson Katie F.
- Lowdon Sarah
- Lowe Hannah
- Lowe Helen L.
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Lythgoe Katrina
- Machin Nicholas W.
- MacIntyre-Cockett George
- Mack Andrew
- Macklin Ben
- Maclean Alasdair
- MacLean Oscar A.
- Macnaughton Emily
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana I. K.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Malone Cassandra S.
- Maloney Daniel
- Manali Maria
- Manesis Nikos
- Manley Robin
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Martincorena Inigo
- Martinez Nunez Rocio T.
- Mather Alison E.
- Maxwell Patrick
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare M.
- McCarthy Shane A.
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J. T.
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McManus Georgina M.
- McMurray Claire
- McMurray Claire L.
- McNally Alan
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Michell Stephen L.
- Michelsen Michelle L.
- Mirfenderesky Mariyam
- Mirza Jeremy
- Miskelly Julia
- Moles-Garcia Emma
- Moll Robin J.
- Molnar Zoltan
- Monahan Irene M.
- Mondani Matteo
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Moore Shona
- Morcrette Helen
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Morriss Arthur
- Moses Samuel
- Mower Craig
- Muir Peter
- Mukaddas Afrida
- Munemo Florence
- Munn Robert
- Murcia Pablo R.
- Murray Abigail
- Murray Darren R.
- Murray Leanne J.
- Murray Sam M.
- Mutingwende Manasa
- Myers Richard
- Nastouli Eleni
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nicholls Sam
- Nichols Jenna
- Nicodemi Roberto
- Nomikou Kyriaki
- O?Brien Sarah
- O?Grady Justin
- O?Toole Áine
- Odedra Mina
- Ohemeng-Kumi Natasha
- Oliver Karen
- Orton Richard
- Orton Richard J.
- Osman Husam
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmarini Massimo
- Park Emily J.
- Park Naomi R.
- Parker Matthew D.
- Parmar Surendra
- Partridge David G.
- Pascall David
- Pascall David J.
- Patel Amita
- Patel Arvind H.
- Patel Bindi
- Paterson Steve
- Payne Brendan A. I.
- Payne Rebecca
- Peacock Sharon J.
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Pinckert Malte L.
- Pinto Rute Maria
- Platt Steven
- Podplomyk Olga
- Pohare Manoj
- Pond Marcus
- Pope Cassie F.
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Prestwood Liam
- Price Anna
- Price James R.
- Prieto Jacqui A.
- Pritchard David T.
- Prosolek Sophie J.
- Pugh Georgia
- Pusok Monika
- Puxty Kathryn
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A.
- Rambaut Andrew
- Ramble John
- Randell Paul
- Randell Paul A.
- Ratcliffe Liz
- Raviprakash Veena
- Ray Surajit
- Raza Mohammad
- Redshaw Nicholas M.
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robson Samuel C.
- Rogan Fiona
- Rooke Stefan
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Ryan Felicity
- Saeed Kordo
- Samaraweera Buddhini
- Sambles Christine M.
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
- Scott Carol
- Scott Garren
- Scott Sam
- Sehmi Jasveen
- Shaaban Sharif
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G.
- Sheridan Liz A.
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silva Vanessa
- Silviera Siona
- Simpson David A.
- Singh Aditi
- Singleton Dawn
- Skvortsov Timofey
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren L.
- Smith Ken
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Perminder
- Smollett Katherine
- Smollett Katherine L.
- Snell Luke B.
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael H.
- Spurgin Lewis G.
- Spyer Moira J.
- Stanley Rachael
- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Szemiel Agnieszka
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben E. W.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton Kate
- Templeton Kate E.
- Thomas Claire
- Thomson Emma C.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tomb Rachael
- Tong Lily
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vink Elen
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Wilkie Craig
- Willett Brian J.
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/08/2022
- Field of study
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273. These data were mirrored by a substantial reduction in real-world vaccine effectiveness that was partially restored by booster vaccination. The Omicron variants BA.1 and BA.2 did not induce cell syncytia in vitro and favoured a TMPRSS2-independent endosomal entry pathway, these phenotypes mapping to distinct regions of the spike protein. Impaired cell fusion was determined by the receptor-binding domain, while endosomal entry mapped to the S2 domain. Such marked changes in antigenicity and replicative biology may underlie the rapid global spread and altered pathogenicity of the Omicron variant
Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes
- Author
- Aanensen David M.
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton S.
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R.
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- Cutino-Moguel Teresa
- da Silva Filipe Ana
- Dabrer Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Delgado Callico Laia
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar R.
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- El Bouzidi Kate
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J.
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Everson William
- Fairley Derek J.
- Fallon Karlie
- Fanaie Arezou
- Farr Ben W.
- Fearn Christopher
- Feltwell Theresa
- Ferguson Lynne
- Fina Laia
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia T.
- Glaysher Sharon
- Goldstein Emily J.
- Golubchik Tanya
- Gomes Andrea N.
- Gonçalves Sónia
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R.
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Guest Martyn
- Gunson Rory N.
- Gupta Ravi K.
- Gutierrez Bernardo
- Haas J.G.
- Haldenby Sam T.
- Hamilton William L.
- Hansford Samantha E.
- Haque Tanzina
- Harris Kathryn A.
- Harrison Ewan M.
- Harrison Ian
- Hart Jennifer
- Hartley John A.
- Harvey Matthew
- Harvey William T.
- Hassan-Ibrahim Mohammed O.
- Heaney Judith
- Helmer Thomas
- Henderson John H.
- Hesketh Andrew R.
- Hey Jessica
- Heyburn David
- Higginson Ellen E.
- Hill Jack D.
- Hill Verity
- Hilson Rachel A.
- Hilvers Ember
- Holden Matthew TG.
- Hollis Amy
- Holmes Alison H.
- Holmes Christopher W.
- Holmes Nadine
- Hopes Richard
- Hornsby Hailey R.
- Hosmillo Myra
- Houlihan Catherine
- Howson-Wells Hannah C.
- Hsu Sharon N.
- Hubb Jonathan
- Huckson Hannah
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Ben
- Jackson Chris
- Jackson David K.
- Jackson Kathryn A.
- Jackson Leigh M.
- Jahun Aminu S.
- James Keith
- James Victoria
- Jeanes Christopher
- Jeffries Aaron R.
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R.
- Jones Hannah
- Jones Neil
- Jones Owen
- Jones Sophie
- Joseph Amelia
- Judges Sarah
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kele Beatrix
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Kidd Stephen P.
- Killough Nicholas F.
- Kimuli Maimuna
- Kirk Stuart
- Kitchen Christine
- Kitchman Katie
- Knight Bridget A.
- Koshy Cherian
- Kraemer Moritz UG.
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G.
- Lampejo Temi
- Langford Cordelia F.
- Lavin Deborah
- Lawton Andrew I.
- Le-Viet Thanh
- Lee David
- Lee Jack CD.
- Lensing Stefanie V.
- Leonard Steven
- Levett Lisa J.
- Lewis Jonathan
- Lewis Kevin
- Liddle Jennifier
- Liggett Steven
- Lillie Patrick J.
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lo Stephanie
- Loman Nicholas J.
- Loose Matthew W.
- Louka Stavroula F.
- Loveson Katie F.
- Lowdon Sarah
- Lowe Hannah
- Lowe Helen L.
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Mack Andrew
- Macklin Ben
- Maclean Alasdair
- Macnaughton Emily
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana IK.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Malone Cassandra S.
- Maloney Daniel
- Manesis Nikos
- Manley Robin
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Markov Anna
- Martincorena Inigo
- Martinez Nunez Rocio T.
- Mather Alison E.
- Maxwell Patrick
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare M.
- McCarthy Shane A.
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McHugh M.P.
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McManus Georgina M.
- McMurray Claire
- McMurray Claire L.
- McNal Alan
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Michell Stephen L.
- Michelsen Michelle L.
- Mirfenderesky Mariyam
- Mirza Jeremy
- Miskelly Julia
- Moles-Garcia Emma
- Moll Robin J.
- Molnar Zoltan
- Monahan Irene M.
- Mondani Matteo
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morcrette Helen
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Morris Arthur
- Moses Samuel
- Mower Craig
- Muir Peter
- Mukaddas Afrida
- Munemo Florence
- Munn Robert
- Murray Abigail
- Murray Darren R.
- Murray Leanne J.
- Mutingwende Manasa
- Myers Richard
- Nastouli Eleni
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nicholls Sam
- Nichols Jenna
- Nicodemi Roberto
- Nomikou Kyriaki
- O'Brien Sarah
- O'Grady Justin
- O'Toole Áine
- Odedra Mina
- Ohemeng-Kumi Natasha
- Oliver Karen
- Orton Richard J.
- Osman Husam
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Park Emily J.
- Park Naomi R.
- Parker Matthew D.
- Parmar Surendra
- Partridge David G.
- Pascall David
- Patel Amita
- Patel Bindi
- Paterson Steve
- Payne Brendan AI.
- Peacock Sharon J.
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Pinckert Malte L.
- Platt Steven
- Podplomyk FD Olga
- Pohare Manoj
- Pond Marcus
- Pope Cassie F.
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Prestwood Liam
- Price Anna
- Price James R.
- Prieto Jacqui A.
- Pritch David T.
- Prosolek Sophie J.
- Pugh Georgia
- Pusok Monika
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A.
- Rambaut Andrew
- Ramble John
- Randell Paul
- Randell Paul A.
- Ratcliffe Liz
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas M.
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robinson Esther
- Robson Samuel C.
- Rogan Fiona
- Rooke Stefan
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Saeed Kordo
- Samaraweera Buddhini
- Sambles Christine M.
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
- Scott Carol
- Scott Garren
- Sehmi Jasveen
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G.
- Sheridan Liz A.
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silviera Siona
- Simpson David A.
- Singh Aditi
- Singleton Dawn
- Skvortsov Timofey
- Sloan Tim J.
- Sluga Graciela
- Smith Colin P.
- Smith Darren L.
- Smith Ken
- Smith Kim S.
- Smith Louise
- Smith Nikki
- Smith Perminder
- Smollett Katherine L.
- Snell Luke B.
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spencer Chapman Michael H.
- Spurgin Lewis G.
- Spyer Moira J.
- Stanley Rachael
- Stanley William
- Stanton Thomas D.
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J.
- Sudhanva Malur
- Swindells Emma
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben EW.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton K.
- Templeton Kate E.
- Thomas Claire
- Thomas-McEwen Peter MD.
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott AJ.
- Todd John A.
- Tomb Rachael
- Tong Lily
- Tonkin-Hill Gerry
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson DipHE Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workma Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/03/2023
- Field of study
Background
The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes.
Aim
To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave.
Methods
A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records.
Findings
In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home.
Conclusion
The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine
The European security and defence policy: What impact on the EU's approach to security challenges?
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning
- Author
- Aanensen David M
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Aplin Stephen
- Ariani Cristina V
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W
- Auckland Cressida
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barrett Jeffrey C
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H
- Beckwith Shaun M
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Bradley Declan T
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F
- Brooks Ellena
- Broos Alice
- Brown Julianne R
- Bucca Giselda
- Buchan Sarah L
- Buck David
- Bull Matthew
- Burns Phillipa J
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Carabelli Alessandro M
- Cargill James S
- Carlile Matthew
- Carmichael Stephen
- Carvalho SÃlvia F
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J
- Chand Mrera
- Chapman Michael H Spencer
- Chappell Joseph G
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Christofidis Nicolaos
- Churcher Carol M
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R
- Cook Kate F
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davies Robert M
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- El Bouzidi Kate
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Enright Jessica
- Ensell Leah
- Erkiert Michelle J
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Everson William
- Fairley Derek J
- Fallon Karlie
- Fanaie Arezou
- Farr Ben W
- Fearn Christopher
- Feltwell Theresa
- Ferguson Lynne
- Fina Laia
- Flaviani Flavia
- Fleming Vicki M
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Fryer Helen
- Fuchs Marc
- Fuller William
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia T
- Glaysher Sharon
- Goldstein Emily J
- Goldstein Emily J
- Golubchik Tanya
- Gomes Andrea N
- Gonçalves Sónia
- Goodfellow Ian G
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffiths Emily
- Guest Martyn
- Gunson Rory N
- Gunson Rory N
- Gupta Ravi K
- Gutierrez Bernardo
- Haldenby Sam T
- Hamilton William L
- Hansford Samantha E
- Haque Tanzina
- Harris Kathryn A
- Harrison Ewan M
- Harrison Ian
- Hart Jennifer
- Harvey Matthew
- Harvey William T
- Hassan-Ibrahim Mohammed O
- Heaney Judith
- Helmer Thomas
- Henderson John H
- Hesketh Andrew R
- Hey Jessica
- Heyburn David
- Higginson Ellen E
- Hill Jack D
- Hill Verity
- Hilson Rachel A
- Hilvers Ember
- Holden Matthew TG
- Holden Matthew TG
- Hollis Amy
- Holmes Alison H
- Holmes Christopher W
- Holmes Nadine
- Hopes Richard
- Hornsby Hailey R
- Hosmillo Myra
- Houlihan Catherine
- Howson-Wells Hannah C
- Hsu Sharon N
- Hubb Jonathan
- Huckson Hannah
- Hughes Joseph
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J
- Illingworth Christopher JR
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Ben
- Jackson Chris
- Jackson David K
- Jackson Kathryn A
- Jackson Leigh M
- Jahun Aminu S
- James Keith
- James Victoria
- Jeanes Christopher
- Jeffries Aaron R
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R
- Jones Hannah
- Jones Neil
- Jones Owen
- Jones Sophie
- Joseph Amelia
- Judges Sarah
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Kidd Stephen P
- Kimuli Maimuna
- Kirk Stuart
- Kitchen Christine
- Kitchman Katie
- Knight Bridget A
- Koshy Cherian
- Kraemer Moritz UG
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G
- Lampejo Temi
- Langford Cordelia F
- Lavin Deborah
- Lawton Andrew I
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Lensing Stefanie V
- Leonard Steven
- Levett Lisa J
- Lewis Jonathan
- Lewis Kevin
- Liddle Jennifier
- Liggett Steven
- Lillie Patrick J
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lo Stephanie
- Loman Nicholas J
- Loose Matthew W
- Louka Stavroula F
- Loveson Katie F
- Lowdon Sarah
- Lowe Hannah
- Lowe Helen L
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Lythgoe Katrina
- Machin Nicholas W
- MacIntyre-Cockett George
- Mack Andrew
- Macklin Ben
- Maclean Alasdair
- Macnaughton Emily
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana IK
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Malone Cassandra S
- Maloney Daniel
- Manesis Nikos
- Manley Robin
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Martincorena Inigo
- Mather Alison E
- Maxwell Patrick
- Mayhew Megan
- Mbisa Tamyo
- McCann Clare M
- McCarthy Shane A
- McCluggage Kathryn
- McClure Patrick C
- McCrone JT
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McManus Georgina M
- McMurray Claire
- McMurray Claire L
- McNally Alan
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Michell Stephen L
- Michelsen Michelle L
- Milosevic Catriona
- Mirfenderesky Mariyam
- Mirza Jeremy
- Miskelly Julia
- Moles-Garcia Emma
- Moll Robin J
- Molnar Zoltan
- Monahan Irene M
- Mondani Matteo
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morcrette Helen
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Morriss Arthur
- Moses Samuel
- Mower Craig
- Muir Peter
- Mukaddas Afrida
- Munemo Florence
- Munn Robert
- Murray Abigail
- Murray Darren R
- Murray Leanne J
- Mutingwende Manasa
- Myers Richard
- Nastouli Eleni
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nicholls Sam
- Nichols Jenna
- Nickbakhsh Sema
- Nicodemi Roberto
- Nomikou Kyriaki
- Nomikou Kyriaki
- Nunez Rocio T Martinez
- Odedra Mina
- Ohemeng-Kumi Natasha
- Oliver Karen
- Orton Richard
- Orton Richard J
- Osman Husam
- O’Brien Sarah
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmalux Natasha
- Park Emily J
- Park Naomi R
- Parker Matthew D
- Parmar Surendra
- Partridge David G
- Pascall David
- Patel Amita
- Patel Bindi
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Pinckert Malte L
- Platt Steven
- Podplomyk Olga
- Pohare Manoj
- Pond Marcus
- Pope Cassie F
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Prestwood Liam
- Price Anna
- Price James R
- Prieto Jacqui A
- Pritchard David T
- Prosolek Sophie J
- Pugh Georgia
- Pusok Monika
- Pybus Oliver G
- Pymont Hannah M
- Quail Michael A
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A
- Rambaut Andrew
- Ramble John
- Randell Paul
- Randell Paul A
- Ratcliffe Liz
- Raviprakash Veena
- Raza Mohammad
- Redshaw Nicholas M
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robson Samuel C
- Rogan Fiona
- Rooke Stefan
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Saeed Kordo
- Samaraweera Buddhini
- Sambles Christine M
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
- Scott Carol
- Scott Garren
- Sehmi Jasveen
- Shaaban Sharif
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G
- Sheridan Liz A
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silviera Siona
- Simpson David A
- Singh Aditi
- Singleton Dawn
- SkvortsovHartley Timofey John A
- Sloan Tim J
- Sluga Graciela
- Smith Colin P
- Smith Darren L
- Smith Ken
- Smith Kim S
- Smith Louise
- Smith Nikki
- Smith Perminder
- Smith-Palmer Alison
- Smollett Katherine
- Smollett Katherine L
- Snell Luke B
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spurgin Lewis G
- Spyer Moira J
- Sreenu Vattipally B
- Stanley Rachael
- Stanley William
- Stanton Thomas D
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J
- Sudhanva Malur
- Swindells Emma
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W
- Tang Miao
- Taylor Ben EW
- Taylor Joshua F
- Taylor Sarah
- Temperton Ben
- Templeton Kate
- Templeton Kate E
- Thomas Claire
- Thomson Emma
- Thomson Emma C
- Thomson Laura
- Thornton Alicia
- Thurston Scott AJ
- Todd John A
- Tomb Rachael
- Tomb Rachael M
- Tong Lily
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Tovar-Corona Jaime M
- Trebes Amy
- Trotter Alexander J
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A
- Umpleby Helen
- Underwood Anthony P
- Vamos Edith E
- Vasylyeva Tetyana I
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Barry B
- Volz Erik M
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K
- Waugh Sheila
- Webster Hermione J
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Willford Nicholas J
- Williams Catryn
- Williams Charlotte A
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T
- Witney Adam A
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A
- Yebra Gonzalo
- Yew Wen C
- Young Gregory R
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 19/07/2022
- Field of study
AbstractWhole genome sequencing of SARS-CoV-2 has occurred at an unprecedented scale, and can be exploited for characterising outbreak risks at the fine-scale needed to inform control strategies. One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student movements at the start of term, close living conditions within residential halls, and high social contact rates. Here we analysed SARS-CoV-2 whole genome sequences in combination with epidemiological data to investigate a large cluster of student cases associated with University of Glasgow accommodation in autumn 2020, Scotland. We identified 519 student cases of SARS-CoV-2 infection associated with this large cluster through contact tracing data, with 30% sequencing coverage for further analysis. We estimated at least 11 independent introductions of SARS-CoV-2 into the student population, with four comprising the majority of detected cases and consistent with separate outbreaks. These four outbreaks were curtailed within a week following implementation of control measures. The impact of student infections on the local community was short-term despite an underlying increase in community infections. Our study highlights the need for context-specific information in the formation of public health policy for higher educational settings.</jats:p
SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2
- Author
- Aanensen David M
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Aplin Stephen
- Ariani Cristina V
- Asad Hibo
- Ash Amy
- Ashby Deborah
- Ashfield Paula
- Ashford Fiona
- Atchison Christina
- Atkinson Laura
- Attwood Stephen W
- Auckland Cressida
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barclay Wendy
- Barrett Jeffrey C
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H
- Beckwith Shaun M
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bodinier Barbara
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F
- Brooks Ellena
- Broos Alice
- Brown Julianne R
- Bucca Giselda
- Buchan Sarah L
- Buck David
- Bull Matthew
- Burns Phillipa J
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Carabelli Alessandro M
- Cargill James S
- Carlile Matthew
- Carvalho Sílvia F
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chadeau-Hyam Marc
- Chalker Vicki
- Chaloner Nicola J
- Chand Meera
- Chapman Michael H Spencer
- Chappell Joseph G
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R
- Cook Kate F
- Cooke Graham
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
- Darby Alistair C
- Darzi Ara
- Davidson Rose K
- Davies Alisha
- Davies Robert M
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Donnelly Christl A
- Dorman Matthew J
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eales Oliver
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- Easton Lisa J
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
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- Eltringham Gary
- Ensell Leah
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- Everson William
- Fairley Derek J
- Fallon Karlie
- Fanaie Arezou
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- Foulser Luke
- Fragakis Mireille
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- Fraser Christophe
- Freeman Timothy M
- Fryer Helen
- Fuchs Marc
- Fuller William
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
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- Girgis Sophia T
- Glaysher Sharon
- Goldstein Emily J
- Golubchik Tanya
- Gomes Andrea N
- Gonçalves Sónia
- Goodfellow Ian G
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Guest Martyn
- Gunson Rory N
- Gupta Ravi K
- Gutierrez Bernardo
- Haldenby Sam T
- Hamilton William L
- Hansford Samantha E
- Haque Tanzina
- Harris Kathryn A
- Harrison Ewan M
- Harrison Ian
- Hart Jennifer
- Hartley John A
- Harvey Matthew
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- Hassan-Ibrahim Mohammed O
- Haw David
- Heaney Judith
- Helmer Thomas
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- Hey Jessica
- Heyburn David
- Higginson Ellen E
- Hill Jack D
- Hill Verity
- Hilson Rachel A
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- Holden Matthew TG
- Hollis Amy
- Holmes Alison H
- Holmes Christopher W
- Holmes Nadine
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- Hornsby Hailey R
- Hosmillo Myra
- Houlihan Catherine
- Howson-Wells Hannah C
- Hsu Sharon N
- Hubb Jonathan
- Huckson Hannah
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Ben
- Jackson Chris
- Jackson David K
- Jackson Kathryn A
- Jackson Leigh M
- Jahun Aminu S
- James Keith
- James Victoria
- Jeanes Christopher
- Jeffries Aaron R
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R
- Jones Hannah
- Jones Neil
- Jones Owen
- Jones Sophie
- Jonnerby Jakob
- Joseph Amelia
- Judges Sarah
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Kidd Stephen P
- Kimuli Maimuna
- Kirk Stuart
- Kitchen Christine
- Kitchman Katie
- Knight Bridget A
- Koshy Cherian
- Kraemer Moritz UG
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G
- Lampejo Temi
- Langford Cordelia F
- Lavin Deborah
- Lawton Andrew I
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Lensing Stefanie V
- Leonard Steven
- Levett Lisa J
- Lewis Jonathan
- Lewis Kevin
- Liddle Jennifier
- Liggett Steven
- Lillie Patrick J
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lo Stephanie
- Loman Nicholas J
- Loose Matthew W
- Louka Stavroula F
- Loveson Katie F
- Lowdon Sarah
- Lowe Hannah
- Lowe Helen L
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Lythgoe Katrina
- Machin Nicholas W
- MacIntyre-Cockett George
- Mack Andrew
- Macklin Ben
- Maclean Alasdair
- Macnaughton Emily
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana IK
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Malone Cassandra S
- Maloney Daniel
- Manesis Nikos
- Manley Robin
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Martincorena Inigo
- Mather Alison E
- Maxwell Patrick
- Mayhew Megan
- Mbisa Tamyo
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- McCluggage Kathryn
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- McCrone JT
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
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- McMurray Claire
- McMurray Claire L
- McNally Alan
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
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- Michelsen Michelle L
- Mirfenderesky Mariyam
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- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morcrette Helen
- Morgan Mari
- Morgan Sian
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- Morriss Arthur
- Moses Samuel
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- Muir Peter
- Mukaddas Afrida
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- Nebbia Gaia
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- Nunez Rocio T Martinez
- Odedra Mina
- Ohemeng-Kumi Natasha
- Oliver Karen
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- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
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- Parmar Surendra
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- Pascall David
- Patel Amita
- Patel Bindi
- Paterson Steve
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- Peacock Sharon J
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Pinckert Malte L
- Platt Steven
- Podplomyk Olga
- Pohare Manoj
- Pond Marcus
- Pope Cassie F
- Poplawski Radoslaw
- Powell Jessica
- Poyner Jennifer
- Prestwood Liam
- Price Anna
- Price James R
- Prieto Jacqui A
- Pritchard David T
- Prosolek Sophie J
- Pugh Georgia
- Pusok Monika
- Pybus Oliver G
- Pymont Hannah M
- Quail Michael A
- Quick Joshua
- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A
- Rambaut Andrew
- Ramble John
- Randell Paul
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- Raza Mohammad
- Redshaw Nicholas M
- Rey Sara
- Reynolds Nicola
- Richter Alex
- Riley Steven
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- Robinson Esther
- Robson Samuel C
- Rogan Fiona
- Rooke Stefan
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Saeed Kordo
- Samaraweera Buddhini
- Sambles Christine M
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
- Scott Carol
- Scott Garren
- Sehmi Jasveen
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G
- Sheridan Liz A
- Sheriff Nicola
- Shirley Lesley
- Sillitoe John
- Silviera Siona
- Simpson David A
- Singh Aditi
- Singleton Dawn
- Skvortsov Timofey
- Sloan Tim J
- Sluga Graciela
- Smith Colin P
- Smith Darren L
- Smith Ken
- Smith Kim S
- Smith Louise
- Smith Nikki
- Smith Perminder
- Smollett Katherine L
- Snell Luke B
- Somassa Thomas
- Southgate Joel
- Spellman Karla
- Spurgin Lewis G
- Spyer Moira J
- Stanley Rachael
- Stanley William
- Stanton Thomas D
- Starinskij Igor
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Studholme David J
- Sudhanva Malur
- Swindells Emma
- Taha Yusri
- Tan Ngee Keong
- Tang Julian W
- Tang Miao
- Taylor Graham
- Taylor Joshua F
- Taylor Sarah
- Temperton Ben
- Templeton Kate E
- Thomas Claire
- Thomson Emma C
- Thomson Laura
- Thornton Alicia
- Thurston Scott AJ
- Todd John A
- Tomb Rachael
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Tovar-Corona Jaime M
- Trebes Amy
- Trotter Alexander J
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A
- Umpleby Helen
- Underwood Anthony P
- Vamos Edith E
- Vasylyeva Tetyana I
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Barry B
- Volz Erik M
- Walsh Sarah
- Wang Dennis
- Wang Haowei
- Ward Helen
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K
- Waugh Sheila
- Webster Hermione J
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Willford Nicholas J
- Williams Catryn
- Williams Charlotte A
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T
- Witney Adam A
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A
- Yebra Gonzalo
- Yew Wen C
- Young Gregory R
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 27/07/2022
- Field of study
Abstract Background Since the emergence of SARS-CoV-2, evolutionary pressure has driven large increases in the transmissibility of the virus. However, with increasing levels of immunity through vaccination and natural infection the evolutionary pressure will switch towards immune escape. Genomic surveillance in regions of high immunity is crucial in detecting emerging variants that can more successfully navigate the immune landscape. Methods We present phylogenetic relationships and lineage dynamics within England (a country with high levels of immunity), as inferred from a random community sample of individuals who provided a self-administered throat and nose swab for rt-PCR testing as part of the REal-time Assessment of Community Transmission-1 (REACT-1) study. During round 14 (9 September–27 September 2021) and 15 (19 October–5 November 2021) lineages were determined for 1322 positive individuals, with 27.1% of those which reported their symptom status reporting no symptoms in the previous month. Results We identified 44 unique lineages, all of which were Delta or Delta sub-lineages, and found a reduction in their mutation rate over the study period. The proportion of the Delta sub-lineage AY.4.2 was increasing, with a reproduction number 15% (95% CI 8–23%) greater than the most prevalent lineage, AY.4. Further, AY.4.2 was less associated with the most predictive COVID-19 symptoms (p = 0.029) and had a reduced mutation rate (p = 0.050). Both AY.4.2 and AY.4 were found to be geographically clustered in September but this was no longer the case by late October/early November, with only the lineage AY.6 exhibiting clustering towards the South of England. Conclusions As SARS-CoV-2 moves towards endemicity and new variants emerge, genomic data obtained from random community samples can augment routine surveillance data without the potential biases introduced due to higher sampling rates of symptomatic individuals. </jats:sec
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study
- Author
- Aanensen David M.
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S. Y.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Antonelli Michela
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Bouzidi Kate El
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Canas Liane S.
- Capdevila Joan
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho Sílvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chapman Michael H. Spencer
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Chen Liyuan
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- Dabrera Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Deng Jie
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Duncan Emma L.
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
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- Ensell Leah
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- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fox Ben
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
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- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
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- Girgis Sophia T.
- Glaysher Sharon
- Goldstein Emily J.
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- Goodfellow Ian G.
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- Goudarzi Salman
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- Gregory Richard
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- Hamilton William L.
- Hammers Alexander
- Hansford Samantha E.
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- Hubb Jonathan
- Huckson Hannah
- Hughes Joseph
- Hughes Margaret
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- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J.
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Ben
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- Jackson Leigh M.
- Jahun Aminu S.
- James Keith
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- John Michaela
- Johnson Kate
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- Jones Christopher R.
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- Kenyon Anita
- Kerfoot Eric
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- Khakh Manjinder
- Kidd Stephen P.
- Kimuli Maimuna
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- Kläser Kerstin
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- Koshy Cherian
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- Kwiatkowski Dominic
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- Leonard Steven
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- Machin Nicholas W.
- MacIntyre-Cockett George
- Mack Andrew
- Macklin Ben
- Maclean Alasdair
- Macnaughton Emily
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana I. K.
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Malone Cassandra S.
- Maloney Daniel
- Manesis Nikos
- Manley Robin
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Martincorena Inigo
- Mather Alison E.
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- Mayhew Megan
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- Mirfenderesky Mariyam
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- Monahan Irene M.
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- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morcrette Helen
- Morgan Mari
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- Morriss Arthur
- Moses Samuel
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- Munemo Florence
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- Nastouli Eleni
- Nebbia Gaia
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- Nomikou Kyriaki
- Nunez Rocio T. Martinez
- Odedra Mina
- Ohemeng-Kumi Natasha
- Oliver Karen
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- Pugh Georgia
- Pusok Monika
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Michael A.
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- Radulescu Clara
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
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- Rambaut Andrew
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- Randell Paul
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- Raviprakash Veena
- Raza Mohammad
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- Robinson Esther
- Robson Samuel C.
- Rogan Fiona
- Rooke Stefan
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- Rudder Steven
- Ruis Chris
- Rushton Steven
- Ryan Felicity
- Saeed Kordo
- Samaraweera Buddhini
- Sambles Christine M.
- Sanderson Roy
- Sanderson Theo
- Sang Fei
- Sass Thea
- Scher Emily
- Scott Carol
- Scott Garren
- Sehmi Jasveen
- Shaaban Sharif
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- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G.
- Sheridan Liz A.
- Sheriff Nicola
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- Sillitoe John
- Silviera Siona
- Simpson David A.
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- Tan Ngee Keong
- Tang Julian W.
- Tang Miao
- Taylor Ben E. W.
- Taylor Joshua F.
- Taylor Sarah
- Temperton Ben
- Templeton Kate E.
- Thomas Claire
- Thomson Emma C.
- Thomson Laura
- Thornton Alicia
- Thurston Scott A. J.
- Todd John A.
- Tomb Rachael
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Tovar-Corona Jaime M.
- Trebes Amy
- Trotter Alexander J.
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A.
- Umpleby Helen
- Underwood Anthony P.
- Vamos Edith E.
- Vasylyeva Tetyana I.
- Vattipally Sreenu
- Vernet Gabrielle
- Vipond Barry B.
- Volz Erik M.
- Walsh Sarah
- Wang Dennis
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K.
- Waugh Sheila
- Webster Hermione J.
- Weldon Danni
- Westwick Elaine
- Whalley Thomas
- Wheeler Helen
- Whitehead Mark
- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T.
- Witney Adam A.
- Wolf Jonathan
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yew Wen Chyin
- Young Greg
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E.
- Zhang Peijun
- Österdahl Marc F.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/06/2022
- Field of study
The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested positive for SARS-CoV-2 from May 26 to July 1, 2021 (Delta overwhelmingly the predominant circulating UK variant), compared (1:1, age- and sex-matched) with individuals presenting from December 28, 2020 to May 6, 2021 (Alpha (B.1.1.7) the predominant variant). We assessed illness (symptoms, duration, presentation to hospital) during Alpha- and Delta-predominant timeframes; and transmission, reinfection, and vaccine effectiveness during the Delta-predominant period. 3581 individuals (aged 18 to 100 years) from each timeframe were assessed. The seven most frequent symptoms were common to both variants. Within the first 28 days of illness, some symptoms were more common with Delta versus Alpha infection (including fever, sore throat, and headache) and some vice versa (dyspnoea). Symptom burden in the first week was higher with Delta versus Alpha infection; however, the odds of any given symptom lasting ≥ 7 days was either lower or unchanged. Illness duration ≥ 28 days was lower with Delta versus Alpha infection, though unchanged in unvaccinated individuals. Hospitalisation for COVID-19 was unchanged. The Delta variant appeared more (1.49) transmissible than Alpha. Re-infections were low in all UK regions. Vaccination markedly reduced the risk of Delta infection (by 69-84%). We conclude that COVID-19 from Delta or Alpha infections is similar. The Delta variant is more transmissible than Alpha; however, current vaccines showed good efficacy against disease. This research framework can be useful for future comparisons with new emerging variants
Genomic reconstruction of the SARS-CoV-2 epidemic in England
- Author
- Aanensen David M
- Abnizova Irina
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Aigrain Louise
- Alcolea Adela
- Alderton Alex
- Ali Mozam
- Alikhan Nabil-Fareed
- Allara Elias
- Allen Laura
- Amato Roberto
- Anderson Ralph
- Angyal Adrienn
- Annett Tara
- Aplin Stephen
- Ariani Cristina
- Ariani Cristina V
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W
- Auckland Cressida
- Austin-Guest Siobhan
- Aydin Alp
- Baker David J
- Baker Paul
- Bala Sendu
- Balcazar Carlos E
- Ball Jonathan
- Barrett Jeffrey
- Barrett Jeffrey C
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew
- Bassett Andrew R
- Batra Rahul
- Battleday Kristina
- Baxter Chris
- Bayzid Nadua
- Beal James
- Beale Mathew
- Beaver Charlotte
- Beckett Angela H
- Beckwith Shaun M
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellany Sam
- Bellerby Tristram
- Bellis Katherine L
- Bellis Katie
- Berger Duncan
- Berriman Matt
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bevan Paul
- Bibby David
- Bicknell Kelly
- Binley Simon
- Binns Debbie
- Birchley Alec
- Bird Paul W
- Birney Ewan
- Bishop Chloe
- Bishop Jason
- Blackburn Kirsty
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Boughton Nick
- Bourgeois Yann
- Bowker Sam
- Boyd Olivia
- Bradley Declan T
- Breen Cassie
- Brendler-Spaeth Timothy
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad
- Bronner Iraad F
- Brooklyn Tanya
- Brooks Ellena
- Broos Alice
- Brown Julianne R
- Bucca Giselda
- Buchan Sarah L
- Buck David
- Buddenborg Sarah Kay
- Bull Matthew
- Burns Phillipa J
- Burton-Fanning Shirelle
- Bush Robert
- Byaruhanga Timothy
- Byott Matthew
- Caetano Catarina
- Cagan Alex
- Campbell Sharon
- Carabelli Alessandro M
- Cargill James S
- Carlile Matthew
- Carter Nicola
- Cartwright Joanna
- Carvalho Sílvia F
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J
- Chand Meera
- Chand Meera
- Chapman Liz
- Chappell Joseph G
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Chillingworth Tracey-Jane
- Churcher Carol M
- Clapham Peter
- Clark Gemma
- Clark Richard
- Clarke Adrian
- Clarke Catriona
- Clarke Phillip
- Cogger Benjamin J
- Cole Daryl
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R
- Cook Elizabeth
- Cook Kate F
- Coombes Jason
- Coppola Maria
- Corden Sally
- Cormie Claire
- Cornell Linda
- Cornwell Clare
- Cortes Nicholas
- Corton Craig
- Cotic Marius
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Crackett Abby
- Craine Noel
- Cranage Alison
- Craven Harriet
- Craw Sarah
- Crawford Liam
- Crawford Mark
- Cross Aidan
- Crown Matthew R
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D
- Curran Tanya
- Cutts Tim
- da Silva Filipe Ana
- Dabrera Gavin
- Dabrowska Monika
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davies Matt
- Davies Robert
- Davies Robert M
- Davis Thomas
- Dawson Joseph
- Day Callum
- de Angelis Daniela
- De Lacy Elen
- De Maio Nicola
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Densem Aiden
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dibling Thomas
- Dobie Donald
- Dockree Cat
- Dodd David
- Dogga Sunil
- Dorman Matthew
- Dorman Matthew J
- Dougan Gordon
- Dougherty Martin
- Dove Alexander
- Downing Fatima
- Drummond Lucy
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dudek Monika
- Durham Jillian
- Durrant Laura
- Easthope Elizabeth
- Eastick Kirstine
- Easton Lisa J
- Eccles Richard
- Eckert Sabine
- Edgeworth Jonathan
- Edwards Sue
- El Bouzidi Kate
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Ellis Pete
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Everson William
- Fairley Derek J
- Fallon Karlie
- Fanaie Arezou
- Farr Ben
- Farr Ben W
- Fearn Christopher
- Feltwell Theresa
- Fenton Michael
- Ferguson Lynne
- Ferrero Marcella
- Fina Laia
- Flack Neil
- Flaviani Flavia
- Fleming Vicki M
- Fordham Howerd
- Forrest Sally
- Forsythe Grace
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francis Matt
- Francois Sarah
- Fraser Audrey
- Fraser Christophe
- Freeman Adam
- Freeman Timothy M
- Fryer Helen
- Fuchs Marc
- Fuller William
- Funk Sebastian
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D
- Gallis Marta
- Galvin Anastasia
- Garcia-Casado Maria
- Gaskin Amy
- Gatica-Wilcox Bree
- Gedny Alex
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gerstung Moritz
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia
- Girgis Sophia T
- Glaysher Sharon
- Glover James
- Goater Richard
- Goldman Nick
- Goldstein Emily J
- Golubchik Tanya
- Gomes Andrea N
- Goncalves Sonia
- Gonçalves Sonia
- Gonçalves Sónia
- Goodfellow Ian G
- Goodwin Scott
- Goudarzi Salman
- Gould Oliver
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R
- Gray Andy
- Gray Emma
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffiths Coline
- Gu Yong
- Guerin Florence
- Guest Martyn
- Gunson Rory N
- Gupta Ravi K
- Gutierrez Bernardo
- Haldenby Sam T
- Hamilton Will
- Hamilton William L
- Hanks Hannah
- Hansford Samantha E
- Haque Tanzina
- Harris Kathryn A
- Harrison Ewan
- Harrison Ewan M
- Harrison Ian
- Harrott Alexandria
- Harry Edward
- Hart Jennifer
- Hartley John A
- Harvey Matthew
- Harvey William T
- Harvison Julia
- Hassan-Ibrahim Mohammed O
- Heaney Judith
- Heath Paul
- Hellewell Joel
- Helmer Thomas
- Henderson John H
- Hernandez-Koutoucheva Anastasia
- Hesketh Andrew R
- Hey Jessica
- Heyburn David
- Higginson Ellen E
- Hill Jack D
- Hill Verity
- Hilson Rachel A
- Hilvers Ember
- Hobbs Rhiannon
- Holden Matthew TG
- Holland Dave
- Hollis Amy
- Holmes Alison H
- Holmes Christopher W
- Holmes Nadine
- Holmes Sarah
- Hopes Richard
- Hornett Gary
- Hornsby Hailey R
- Hosmillo Myra
- Hough Nicholas
- Houlihan Catherine
- Howson-Wells Hannah C
- Hsu Sharon N
- Hubb Jonathan
- Huckle Liz
- Huckson Hannah
- Hughes Joseph
- Hughes Margaret
- Hughes Warwick
- Hughes-Hallet Lena
- Hunter Adam
- Hutchings Stephanie
- Idle Giles
- Illingworth Chris J
- Impey Robert
- Inglis Stephen
- Iqbal Sameena
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Izuagbe Rhys
- Jackson Adam
- Jackson Ben
- Jackson Chris
- Jackson David
- Jackson David K
- Jackson Kathryn A
- Jackson Leigh M
- Jahun Aminu S
- James Keith
- James Victoria
- Jamrozy Dorota
- Jeanes Christopher
- Jeffries Aaron R
- Jeremiah Sarah
- Jermy Andrew
- John Michaela
- Johnson Kate
- Johnson Rob
- Johnston Ian
- Jones Christopher R
- Jones Hannah
- Jones Matthew
- Jones Neil
- Jones Owen
- Jones Sophie
- Joseph Amelia
- Judges Sarah
- Jung Alexander W
- Kallepally Kalyan
- Kane Leanne
- Kay Gemma L
- Kay Keely
- Kay Sally
- Keatley Jon
- Keatley Jon-Paul
- Keeley Alexander J
- Keith Alan
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Kidd Stephen P
- Kimuli Maimuna
- King Alison
- Kirk Stuart
- Kitchen Christine
- Kitchin Lucy
- Kitchman Katie
- Kleanthous Matt
- Klimekova Martina
- Knight Bridget A
- Korlevic Petra
- Koshy Cherian
- Kraemer Moritz UG
- Krasheninnkova Ksenia
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Kwiatkowski Dominic
- Lackenby Angie
- Laing Kenneth G
- Lampejo Temi
- Lane Greg
- Langford Cordelia
- Langford Cordelia F
- Laverack Adam
- Lavin Deborah
- Law Katharine
- Lawniczak Mara
- Lawton Andrew I
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Lensing Stefanie
- Lensing Stefanie V
- Leonard Steven
- Letchford Laura
- Levett Lisa J
- Lewis Jonathan
- Lewis Kevin
- Lewis-Wade Amanah
- Liddle Jennifer
- Liddle Jennifier
- Liggett Steven
- Lillie Patrick J
- Lin Quan
- Lindsay Sarah
- Lindsey Benjamin B
- Linsdell Sally
- Lister Michelle M
- Livett Rich
- Lo Stephanie
- Loman Nicholas J
- Long Rhona
- Loose Matthew W
- Louka Stavroula F
- Lovell Jamie
- Lovell Jon
- Loveson Katie F
- Lowdon Sarah
- Lowe Hannah
- Lowe Helen L
- Lucaci Anita O
- Ludden Catherine
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Lythgoe Katrina
- Machin Nicholas W
- MacIntyre-Cockett George
- Mack Andrew
- Mack James
- Macklin Ben
- Maclean Alasdair
- Macnaughton Emily
- Maddison Mark
- Madona Pinglawathee
- Maes Mailis
- Maftei Laurentiu
- Mahanama Adhyana IK
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Makunin Aleksei
- Malone Cassandra S
- Maloney Daniel
- Mamun Irfan
- Manesis Nikos
- Manley Robin
- Mansfield Jenny
- Mantzouratou Anna
- Marchbank Angela
- Mariappan Arun
- Marriott Neil
- Martin Matt
- Martincorena Inigo
- Martinez Nunez Rocio T
- Masters Kathryn McCluggage
- Mather Alison E
- Maxwell Patrick
- Mayhew Megan
- Mayho Matthew
- Mbisa Tamyo
- McCann Clare M
- McCarthy Shane
- McCarthy Shane A
- McClintock Jo
- McClure Patrick C
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McHugh Sandra
- McKenna James P
- McKerr Caoimhe
- McManus Georgina M
- McMinn Liz
- McMurray Claire
- McMurray Claire L
- McNally Alan
- Meadows Carl
- Meadows Lizzie
- Medd Nathan
- Megram Oliver
- Menegazzo Mirko
- Merrick Ian
- Michell Stephen L
- Michelsen Michelle L
- Mirfenderesky Mariyam
- Mirza Jeremy
- Miskelly Julia
- Mobley Emily
- Moles-Garcia Emma
- Moll Robin
- Moll Robin J
- Molnar Zoltan
- Monahan Irene M
- Mondani Matteo
- Monteiro Tiago Carvalho
- Mookerjee Siddharth
- Moore Catherine
- Moore Christopher
- Moore Jonathan
- Moore Nathan
- Morcrette Helen
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Morra Maria
- Morriss Arthur
- Morrow Leanne
- Moses Samuel
- Mower Craig
- Muir Peter
- Mukaddas Afrida
- Munemo Florence
- Munn Robert
- Murie Kathryn
- Murray Abigail
- Murray Darren R
- Murray Leanne J
- Mutingwende Manasa
- Myers Richard
- Nash Sian
- Nastouli Eleni
- Nathwani Claire
- Naydenova Plamena
- Neaverson Alexandra
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nerou Ed
- Nguyen Thuy
- Nicholls Sam
- Nichols Jenna
- Nicholson Jon
- Nicodemi Roberto
- Nimz Tabea
- Noell Guillaume G
- Nomikou Kyriaki
- Odedra Mina
- Ohan Valeriu
- Ohemeng-Kumi Natasha
- Oliver Karen
- Olney Charles
- Ormond Doug
- Orton Richard J
- Osman Husam
- Oszlanczi Agnes
- O’Brien Sarah
- O’Grady Justin
- O’Meara Sarah
- O’Toole Áine
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Steve
- Pang Yoke Fei
- Panovska-Griffiths Jasmina
- Pardubska Barbora
- Park Emily J
- Park Naomi
- Park Naomi R
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- Parmar Aaron
- Parmar Surendra
- Partridge David G
- Pascall David
- Patel Amita
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- Patel Gaurang
- Patel Minal
- Paterson Steve
- Payne Brendan AI
- Payne Maggie
- Peacock Sharon
- Peacock Sharon J
- Pearson Clare
- Pelosi Emanuela
- Percival Benita
- Perkins Jon
- Perry Malorie
- Petersen Arabella
- Pinckert Malte L
- Platt Steven
- Plowman Deborah
- Podplomyk Olga
- Pohare Manoj
- Pond Marcus
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- Poplawski Radoslaw
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- Prestwood Liam
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- Pugh Georgia
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- Pybus Oliver G
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- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajan Diana
- Rajatileka Shavanthi
- Ramadan Newara A
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- Ramble John
- Rance Richard
- Randell Paul
- Randell Paul A
- Ratcliffe Liz
- Raviprakash Veena
- Rawlings Suzannah
- Raza Mohammad
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- Redshaw Nicholas M
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- Reynolds Mark
- Reynolds Nicola
- Rice Simon
- Richardson Matt
- Richter Alex
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- Robinson Esther
- Robinson Katrina
- Robinson Melanie
- Robson Samuel C
- Rogan Fiona
- Rogers Hazel
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- Rooke Stefan
- Roopra Daljit
- Rose Mark
- Rowe Will
- Roy Sunando
- Rudd Luke
- Rudder Steven
- Ruis Chris
- Rushton Steven
- Sadri Ramin
- Saeed Kordo
- Saint Callum
- Salmon Nicholas
- Samaraweera Buddhini
- Sambles Christine M
- Sanderson Roy
- Sanderson Theo
- Sanderson Theo
- Sang Fei
- Sass Thea
- Saul David
- Scher Emily
- Schwach Frank
- Schwach Frank
- Scott Carol
- Scott Garren
- Seekings Phil
- Sehmi Jasveen
- Shaaban Sharif
- Shah Divya
- Shaw Jessica
- Shelest Ekaterina
- Shepherd James G
- Sheridan Liz A
- Sheriff Nicola
- Shirley Lesley
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- Silviera Siona
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- Simpson David A
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- Singleton Dawn
- Sinnott Matthew
- Sinnott Matthew
- Sivadasan Shanthi
- Siwek Bart
- Sizer Dale
- Skeldon Kenneth
- Skelton Jason
- Skvortsov Timofey
- Slater-Tunstill Joanna
- Sloan Tim J
- Sloper Lisa
- Sluga Graciela
- Smerdon Nathalie
- Smith Chris
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith James
- Smith Katie
- Smith Ken
- Smith Kim S
- Smith Louise
- Smith Michelle
- Smith Nikki
- Smith Perminder
- Smith Sean
- Smith Tina
- Smollett Katherine L
- Sneade Leighton
- Snell Luke B
- Somassa Thomas
- Soria Carmen Diaz
- Sousa Catarina
- Souster Emily
- Southgate Joel
- Sparkes Andrew
- Spellman Karla
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- Spencer-Chapman Michael
- Spurgin Lewis G
- Spyer Moira J
- Squares Janet
- Stanley Rachael
- Stanley Robert
- Stanley William
- Stanton Thomas D
- Starinskij Igor
- Steed Claire
- Stickland Tim
- Still Ian
- Stockton Joanne
- Stonehouse Susanne
- Storey Nathaniel
- Stratton Michael R
- Strickland Michelle
- Studholme David J
- Suciu Maria
- Sudhanva Malur
- Swann Allen
- Swiatkowska Agnieszka
- Swift Emma
- Swindells Emma
- Sycamore Neil
- Symons Edward
- Szluha Suzanne
- Taha Yusri
- Taluy Emma
- Tan Ngee Keong
- Tang Julian W
- Tang Miao
- Tao Nunu
- Taylor Ben EW
- Taylor Joshua F
- Taylor Katy
- Taylor Sam
- Taylor Sarah
- Temperton Ben
- Templeton Kate E
- Thomas Claire
- Thompson Mark
- Thompson Stacey
- Thomson Emma C
- Thomson Laura
- Thomson Mark
- Thomson Nicholas
- Thornton Alicia
- Thurston Scott
- Thurston Scott AJ
- Todd John A
- Tomb Rachael
- Tong Lily
- Tonkin-Hill Gerry
- Toombs Dee
- Topping Benjamin
- Torok M Estee
- Tovar-Corona Jaime
- Tovar-Corona Jaime M
- Trebes Amy
- Trotter Alexander J
- Tsatsani Ioulia
- Turnbull Robyn
- Turtle Lance
- Twohig Katherine A
- Umpleby Helen
- Underwood Anthony P
- Ungureanu Daniel
- Uphill James
- Urbanova Jana
- Vamos Edith E
- Van Vuuren Philip Jansen
- Vancollie Valerie
- Vasylyeva Tetyana I
- Vattipally Sreenu
- Verdejo Carlos Jimenez
- Vernet Gabrielle
- Vipond Barry B
- Voak Paul
- Volz Erik
- Volz Erik M
- Vöhringer Harald S
- Walker Danielle
- Walker Matthew
- Waller Matt
- Walsh Sarah
- Wang Dennis
- Ward Gary
- Warne Ben
- Warwick-Dugdale Joanna
- Wastnedge Elizabeth
- Watkins Joanne
- Watson Louisa K
- Waugh Sheila
- Weatherhogg Charlie
- Webb Niki
- Webster Hermione J
- Weldon Danni
- Wells Alan
- Wells Eloise
- Westwick Elaine
- Westwood Luke
- Whalley Thomas
- Wheeler Helen
- Whipp Theo
- Whitehead Mark
- Whiteley Max
- Whiteley Thomas
- Whitton Georgia
- Whitwham Andrew
- Widaa Sara
- Wierzbicki Claudia
- Willford Nicholas J
- Williams Catryn
- Williams Charlotte A
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Mia
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Wilson Mark
- Wilson-Davies Eleri
- Witele Eric
- Withell Karen T
- Witney Adam A
- Wolverson Paige
- Wong Nick
- Workman Trudy
- Wright Derek W
- Wright Sean
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A
- Yebra Gonzalo
- Yew Wen C
- Young Gregory R
- Young Jamie
- Zamudio Marina Escalera
- Zarebski Alex E
- Zhang Peijun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 14/10/2021
- Field of study
AbstractThe evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump in transmissibility of the B.1.1.7/Alpha lineage. The Alpha variant grew when other lineages declined during the second national lockdown and regionally tiered restrictions between November and December 2020. A third more stringent national lockdown suppressed the Alpha variant and eliminated nearly all other lineages in early 2021. Yet a series of variants (most of which contained the spike E484K mutation) defied these trends and persisted at moderately increasing proportions. However, by accounting for sustained introductions, we found that the transmissibility of these variants is unlikely to have exceeded the transmissibility of the Alpha variant. Finally, B.1.617.2/Delta was repeatedly introduced in England and grew rapidly in early summer 2021, constituting approximately 98% of sampled SARS-CoV-2 genomes on 26 June 2021.</jats:p