Antietam Colossal Granite Statue. Sculpted at Batterson\u27s Quarry Westerly, R.I.

The stereograph features a black and white image of the statue The American Volunteer, which depicts a man dressed in a military uniform. The statue is full-length and the subject stands at parade rest and holds a gun. Two beams and a rope frame the statue on either side. Two houses stand in the background. The albumen print is mounted on a yellow card with rounded edges. The card\u27s reverse contains contributor information as well as additional information about the statue.https://scholarsjunction.msstate.edu/fvw-photographs/1210/thumbnail.jp

Antietam Colossal Granite Statue. Sculpted at Batterson\u27s Quarry Westerly, R.I.

The stereograph features a black and white image of the statue The American Volunteer, which depicts a man dressed in a military uniform. The statue is full-length and the subject stands at parade rest and holds a gun. Two beams and a rope frame the statue on either side. Two houses stand in the background. The albumen print is mounted on a yellow card with rounded edges. The card\u27s reverse contains contributor information as well as additional information about the statue.https://scholarsjunction.msstate.edu/fvw-artifacts/1524/thumbnail.jp

Pathology Features in Bethesda Guidelines Predict Colorectal Cancer Microsatellite Instability: A Population-Based Study

Malaysia - Hydraulic tin miningColorVolume 6, Page

Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: A population-based study

Copyright © 2007 AGA Institute Published by Elsevier Inc.Background & Aims: The revised Bethesda guidelines for Lynch syndrome recommend microsatellite instability (MSI) testing all colorectal cancers in patients diagnosed before age 50 years and colorectal cancers diagnosed in patients between ages 50 and 59 years with particular pathology features. Our aim was to identify pathology and other features that independently predict high MSI (MSI-H). Methods: Archival tissue from 1098 population-based colorectal cancers diagnosed before age 60 years was tested for MSI. Pathology features, site, and age at diagnosis were obtained. Multiple logistic regression was performed to determine the predictive value of each feature, as measured by an odds ratio (OR), from which a scoring system (MsPath) was developed to estimate the probability a colorectal cancer is MSI-H. Results: Fifteen percent of tumors (162) were MSI-H. Independent predictors were tumor-infiltrating lymphocytes (OR, 9.1; 95% confidence interval [CI], 5.9–14.1), proximal subsite (OR, 4.7; 95% CI, 3.1–7.3), mucinous histology (OR, 2.8; 95% CI, 1.7–4.8), poor differentiation (OR, 1.9; 95% CI, 1.2–3.1), Crohn’s-like reaction (OR, 1.9; 95% CI, 1.2–2.9), and diagnosis before age 50 years (OR, 1.9; 95% CI, 1.3–2.9). MsPath score ≥1.0 had a sensitivity of 93% and a specificity of 55% for MSI-H. Conclusions: The probability an individual colorectal cancer is MSI-H is predicted well by the MsPath score. There is little value in testing for DNA mismatch repair loss in tumors, or for germline mismatch repair mutations, for colorectal cancers diagnosed in patients before age 60 years with an MSPath score <1 (approximately 50%). Pathology can identify almost all MSI-H colorectal cancers diagnosed before age 60 years.http://www.elsevier.com/wps/find/journaldescription.cws_home/623297/description#descriptio