Empowering statistical methods for cellular and molecular biologists.

We provide guidelines for using statistical methods to analyze the types of experiments reported in cellular and molecular biology journals such as Molecular Biology of the Cell. Our aim is to help experimentalists use these methods skillfully, avoid mistakes, and extract the maximum amount of information from their laboratory work. We focus on comparing the average values of control and experimental samples. A Supplemental Tutorial provides examples of how to analyze experimental data using R software

The Dr Elizabeth Casson Memorial Lecture 2018: Occupational stories from a global city

The Dr Elizabeth Casson Memorial Lecture 2018, given on June 12th 2018 at the 42nd Annual Conference and Exhibition of the Royal College of Occupational Therapists, held at the Belfast Waterfront, Belfast, UK. This lecture aims to set out the potential for the global occupational therapy profession to exchange knowledge for social transformation practice. It identifies the profession’s concern with narratives as a vehicle for a socially critical approach to occupation, which can be used to negotiate intervention and action. Drawing on examples from literature, history and service users, the paper suggests that narrative provides a means for relating the value of occupation beyond professional boundaries to capture popular imagination and demand for the profession. Examples are given of the critical discussion of the everyday impact of health inequity, and in addressing diversity both in the profession and engaging service users. My lecture concludes that occupational therapy is a global network with the population of a city, and thus represents a community that can be a vibrant voice for social transformation through occupation through a reciprocal exchange of narrative. This is a collective and dialogical process which can draw on the experiences of both southern and northern hemispheres

Trigger warnings about war graves do not molly-coddle archaeology students, they are essential

No abstract available

The Visible and the Invisible Hilary Mantel

This talk addresses the scarcity of critical material on Hilary Mantel’s writing in the academy. It questions the suitability of the ‘origin’ paradigm within the criticism that is available, which closes off the excess of Mantel’s texts through attempts to ‘unite’ her corpus. The ambiguity of her writing, and its suspicions, suggest Jacques Derrida’s thought as a pertinent means to read the differences in her work differently. The proximity of Jean-Luc Nancy’s philosophy with Derrida’s thought allows the significance of ellipsis to surface as a liberating catalyst for weaving the implications of Derrida’s thinking through the writing of Mantel. This synthesis constitutes an original combination because Mantel’s writing has not been closely studied, Derrida’s notion of ellipsis has been eclipsed by philosophy, and the combination of these two ‘invisibilities’ is seminal. The talk begins with an exploration of the mythologies I discovered and interrogated during the course of my thesis. It then considers the key points in Mantel’s writing career. In particular taking her from the difficulty and invisibility of 1979 when A Place of Greater Safety, her first novel, was rejected, to winning the Booker prize twice in succession in 2009 and 2012. It thereby traces the story of her shift from invisible to infamous, in terms of her treatment by the mainstream British media as well as her phenomenal post-millennium success.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Open Markov processes: A compositional perspective on non-equilibrium steady states in biology

In recent work, Baez, Fong and the author introduced a framework for describing Markov processes equipped with a detailed balanced equilibrium as open systems of a certain type. These `open Markov processes' serve as the building blocks for more complicated processes. In this paper, we describe the potential application of this framework in the modeling of biological systems as open systems maintained away from equilibrium. We show that non-equilibrium steady states emerge in open systems of this type, even when the rates of the underlying process are such that a detailed balanced equilibrium is permitted. It is shown that these non-equilibrium steady states minimize a quadratic form which we call `dissipation.' In some circumstances, the dissipation is approximately equal to the rate of change of relative entropy plus a correction term. On the other hand, Prigogine's principle of minimum entropy production generally fails for non-equilibrium steady states. We use a simple model of membrane transport to illustrate these concepts

Now the wars are over: The past, present and future of Scottish battlefields

Battlefield archaeology has provided a new way of appreciating historic battlefields. This paper provides a summary of the long history of warfare and conflict in Scotland which has given rise to a large number of battlefield sites. Recent moves to highlight the archaeological importance of these sites, in the form of Historic Scotland’s Battlefields Inventory are discussed, along with some of the problems associated with the preservation and management of these important cultural sites

A Second Law for Open Markov Processes

In this paper we define the notion of an open Markov process. An open Markov process is a generalization of an ordinary Markov process in which populations are allowed to flow in and out of the system at certain boundary states. We show that the rate of change of relative entropy in an open Markov process is less than or equal to the flow of relative entropy through its boundary states. This can be viewed as a generalization of the Second Law for open Markov processes. In the case of a Markov process whose equilibrium obeys detailed balance, this inequality puts an upper bound on the rate of change of the free energy for any non-equilibrium distribution.Comment: 9 pages, 3 figure