Magnetic relaxation of type II superconductors in a mixed state of entrapped and shielded flux

The magnetic relaxation has been investigated in type II superconductors when the initial magnetic state is realized with entrapped and shielded flux (ESF) contemporarily. This flux state is produced by an inversion in the magnetic field ramp rate due to for example a magnetic field overshoot. The investigation has been faced both numerically and by measuring the magnetic relaxation in BSCCO tapes. Numerical computations have been performed in the case of an infinite thick strip and of an infinite slab, showing a quickly relaxing magnetization in the first seconds. As verified experimentally, the effects of the overshoot cannot be neglected simply by cutting the first 10-100 seconds in the magnetic relaxation. On the other hand, at very long times, the magnetic states relax toward those corresponding to field profiles with only shielded flux or only entrapped flux, depending on the amplitude of the field change with respect to the full penetration field of the considered superconducting samples. In addition, we have performed numerical simulations in order to reproduce the relaxation curves measured on the BSCCO(2223) tapes; this allowed us to interpret correctly also the first seconds of the $M(t)$ curves.Comment: 9 pages, 12 figures submit to PR

Harmonics of the AC susceptibility as probes to differentiate the various creep models

We measured the temperature dependence of the 1st and the 3rd harmonics of the AC magnetic susceptibility on some type II superconducting samples at different AC field amplitudes, hAC. In order to interpret the measurements, we computed the harmonics of the AC susceptibility as function of the temperature T, by integrating the non-linear diffusion equation for the magnetic field with different creep models, namely the vortex glass-collective creep (single-vortex, small bundle and large bundle) and Kim-Anderson model. We also computed them by using a non-linear phenomenological I-V characteristics, including a power law dependence of the pinning potential on hAC. Our experimental results were compared with the numerically computed ones, by the analysis of the Cole-Cole plots. This method results more sensitive than the separate component analysis, giving the possibility to obtain detailed information about the contribution of the flux dynamic regimes in the magnetic response of the analysed samples.Comment: 9 pages, 6 figures, submitted to Physica

A new method to detect the vortex glass phase and its evidence in YBCO

The Vortex Glass phase has been unequivocally identified by analyzing the non linear magnetic response of type II superconductors. The method here introduced, more effective than the study of direct transport measurements, is based on a combined frequency dependence analysis of the real and imaginary part of the 1st and 3rd harmonics of the AC magnetic susceptibility. The analysis has been performed by taking into account both the components and the Cole-Cole plots (i.e. the imaginary part as a function of the real part). Numerical simulations have been used to individuate the fingerprints of the magnetic behaviour in the Vortex Glass phase. These characteristics allowed to distinguish the Vortex Glass phase from the other disordered phases, even those showing similar electrical properties. Finally, this method has been successfully applied to detect the Vortex Glass Phase in an YBCO bulk melt-textured sample.Comment: 15 pages, 12 figure

Third Harmonics of the AC Magnetic Susceptibility: a method for the study of flux dynamics in High Temperature Superconductors

The temperature dependence of the 1st and 3rd harmonics of the AC magnetic susceptibility has been measured on melt grown YBCO samples for different frequencies and amplitudes of the AC magnetic field and intensity of a contemporaneously applied DC field. With the help of critical state models and of numerical simulations, we have devised a novel method, based on the combined analysis of the 1st and the 3rd harmonics that allows to distinguish different temperature ranges dominated by the different dissipative magnetic flux regimes. In particular, we identified three principal zones in the temperature dependence of the real part of the 3rd harmonic: the zone 1, in the temperature range below the peak of the imaginary part of the 1st harmonic, Tp, and the zone 2, characterized by negative values in a temperature region of the real part of the 3rd harmonics, just above Tp, both dominated by the creep regime; the zone 3, just below Tc, in which we revealed the presence of Thermally Assisted Flux Flow (TAFF). By the identification of these zones, an estimation of the value of the pinning potential can be obtained.Comment: 28 pages, 8 figures, to be published on Europ. Phys. Journ.

Identification of the vortex glass phase by harmonics of the AC magnetic susceptibility

We compared the AC magnetic susceptibility behaviour for the vortex glass phase and for the creep phenomena with an inhomogeneous pinning potential. The temperature dependence of the harmonics of the susceptibility have been numerically simulated with these two models, and we studied them as a function of the frequency, in terms of Cole-Cole plots. From our analysis we show that it is possible to distinguish between the two different phases, because of their clear differences in the Cole-Cole plots behaviour with the frequency.Comment: 8 pages, 2 figures to be published on "The Journal of Physics and Chemistry of Solids

H(T) Phase Diagram in Nb3Sn: A Different Behavior in Single Crystals, Polycristalline Samples and Multifilamentary Wires

A comparative study of magnetic behavior in a DC magnetic field up to 19 Tesla has been undertaken on different Nb3Sn samples, i.e. single crystals, polycrystal samples and multifilamentary wires. From the 1st and 3rd harmonics of the AC magnetic susceptibility a peak effect was experimentally observed in the single crystal and in the polycrystal, whereas this phenomenon is absent in the measured wires. The corresponding H vs T phase diagram reveals a different behavior between wires on one hand and polycrystalline and single crystal samples on the other. In particular, from the 3rd harmonics it has been observed that vortex thermally activated flux creep phenomena are relevant in the wires, whereas the static critical state models are more appropriate to describe single crystals.Comment: 9 pages, 9 figures, to be published on Advances in Cryogenic Engineering, Vol. 51-52 (CEC-ICMC05, Keystone, Colorado, 28 August-3 September 2005

Detection of the Vortex Dynamic Regimes in MgB2 by Third Harmonic AC Susceptibility Measurements

In a type-II superconductor the generation of higher harmonics in the magnetic response to an alternating magnetic field is a consequence of the non-linearity in the I-V relationship. The shape of the current-voltage (I-V) curve is determined by the current dependence of the thermal activation energy U(J) and is thus related to the dynamical regimes governing the vortex motion. In order to investigate the vortex dynamics in MgB2 bulk superconductors we have studied the fundamental (chi1) and third (chi3) harmonics of the ac magnetic susceptibility. Measurements have been performed as a function of the temperature and the dc magnetic field, up to 9 T, for various frequencies and amplitudes of the ac field. We show that the analysis of the behaviour in frequency of chi3(T) and chi3(B) curves can provide clear information about the non-linearity in different regions of the I-V characteristic. By comparing the experimental curves with numerical simulations of the non-linear diffusion equation for the magnetic field we are able to resolve the crossover between a dissipative regime governed by flux creep and one dominated by flux flow phenomena.Comment: to be published in "Horizons in Superconductivity Research" (Nova Science Publishers, Inc., NY, 2003

Analytical and pharmacological aspects of therapeutic drug monitoring of mTOR inhibitors

Mammalian Target Of Rapamycin (mTOR) inhibitors represent a new class of immunosuppressant drugs extensively used for the prevention and the treatment of graft rejection in organ transplant recipients. Their current use is due to referred low nephrotoxic effects, particularly important in kidney transplanted and/or patients with renal failure. The most representative drugs of such class are Sirolimus (Siro) and Everolimus (Rad). Both drugs show a narrow therapeutic window, therefore, monitoring of whole-blood drug levels is recommended in order to optimize the therapy. Among the available assays, Liquid Chromatography coupled with UltraViolet or Electrospray Tandem Mass Spectrometry methods (LC/UV or LC/ESI-MSMS) are the most accurate and specific ones. A reliable alternative is represented by immunoassays, which offer the opportunity to minimize sample pre-treatment, thus reducing the time between drawing blood sample and measuring the drug concentration, an important aspect in high-throughput analyses. Despite this, a limitation in the use of immunoassays for therapeutic drug monitoring is the lower specifity compared with the chromatographic methods when analysing structurally-related drugs. New insights to optimize mTOR inhibitors regimens seem to be offered by the evaluation of CYP450 3A activity by using the probe drug approach. To such purpose, there are a number of major probe drugs used for in vivo studies including: midazolam, cortisol, lidocaine, nifedipine, dextromethorphan, erythromycin, dapsone and alfentanil. The aim of the present paper is to report the most recent knowledge concerning this issue, supplying a critical and comprehensive review for whom are involved both in the clinical and analytical areas