Sequence Stratigraphy and Onlap History of the Donets Basin, Ukraine: Insight into Carboniferous Icehouse Dynamics

The degree to which Permo-Carboniferous cyclothemic successions archive evidence for long-term variations in ice volume during the Late Paleozoic Ice Age is insufficiently resolved. Here we develop the sequence stratigraphy and onlap-offlap history for a 33-my interval of the Carboniferous using the U-Pb calibrated succession of the Donets Basin, Ukraine, in order to assess the relationship between sea-level, high-latitude changes in glacial extent, and climate. Integrated subsurface and outcrop data permit meter-scale correlation of 242 biostratigraphically constrained limestones and coals, and in turn individual cyclothems, across ~250 km of the Donets Basin. Rapid uniform subsidence and basinwide continuity of marker beds indicate Pennsylvanian deposition under relatively stable tectonic conditions. Three scales of sequences (avg. durations of ~140 ky, ~480 ky and 1.6 my) are recognized on the basis of stratigraphic stacking patterns and basinwide architecture of marine to terrestrial facies assemblages. The hierarchy of sequences and the geographic and stratigraphic positions of shifts in base-level sensitive facies across the Donets ramp permit the construction of an onlap-offlap history at a sub-400 ky scale. Major sea-level lowstands occur across the mid-Carboniferous boundary and during the early Moscovian. These lowstands coincide with glacial maxima inferred from high-latitude glacigenic deposits. The middle to late Pennsylvanian is characterized by a stepwise onlap, culminating in an earliest Gzhelian highstand, suggesting contraction of Carboniferous ice sheets prior to the initiation of Early Permian glaciation. The stratigraphic position of climate sensitive facies within individual Donets cyclothems indicates a turnover from seasonal sub-humid or semi-arid climate to everwet conditions during the late lowstand and maximum ice sheet accumulation. Comparison of the stratigraphic and aerial distribution of coals and evaporites in the Donets Basin with the onlap-offlap history further indicates everwet conditions during lowstands and inferred glacial maxima and drier climate during onlap and inferred ice sheet contraction at the intermediate (~0.8 to 1.6 my) and long (106 yr) time-scales. Taken together, the relationship between inferred climate and glacioeustasy suggests a likely teleconnection between high-latitude ice sheet behavior and low-latitude atmospheric dynamics

ФОРМУВАННЯ ГАЗОМЕТАЛЕВОГО ПОТОКУ В УМОВАХ «ХІМІЧНОГО» ВАКУУМУ У СТАЛЕВИПУСКНОМУ КАНАЛІ

The results of laboratory research to determine the hydro-gas-dynamic patterns the formation of gas-metal flow at an tapping from an oxygen converter to steel ladle are given due to the injection of subsonic argon jets into the melt flow through nozzles located in the steel-tapping channel.Using the method of low-temperature simulation, determined the influence of design parameters of the proposed design of a two-chamber steel-tapping channel (length of the reaction zone, the number and location of gas nozzles) and gas consumption on the degree of organization and protection of the gas-liquid flow (GLF) when the gas blowing into the working space of the steel-tapping channel.Was obtained mathematical relation characterizing the mutual influence on the opening angle of the GLF between of the relative length of the "reaction zone" (x) and the gas flow rate through the nozzle. It is shown that when the length of the "reaction zone" decreases, an extremum occurs at lower gas consumption, and the value of "subcritical" gas consumption has a greater range. So, when the length of the "reaction zone" decreases, an extremum occurs at lower gas consumption, and the value of "subcritical" gas consumption has a greater range.The possibility of retaining the angle of disclosure of the gas-liquid flow (α) in the range of up to 5° with a relative length of the reaction zone of 0,75 has been proved. It is shown that with an increase of α from 1...3° to 10°, the efficiency of the protective action of argon (k) decreases from 0,99 to 0,72. At x = 0,75, the coefficient k is in the range of 0,89...0,99. It is established that when the critical gas flow is exceeded and x = 0,25, the value of α rises to an inadmissible 10...15°.The classification of the purges of the melt flow in the steel-tapping channel is proposed, depending on the angle of inclination of the gas jets relative to the axis of the last (γ) in accordance with which are allocated: the mode of "interruption" (γ > 78°), at which the gas jets unclosed, the formation of the gas-liquid flow does not occur; the mode of "closing" (0  78°), при якому газові струмені розімкнуті, формування газорідинного потоку не відбувається; режим «змикання» (0 < γ < 78°), при якому газові потоки об’єднані, формується газорідинний потік з розвиненою міжфазною поверхнею і високим ступенем організації, та режим «пробою» (γ = 0°), при якому подальше збільшення витрати газу, що перевищує критичну, призводить до пробою і руху газорідинного потоку у дисперсно-кільцевому режимі із зменшенням ступеня організації потоку

Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis

The mechanisms operating in lymphocyte recruitment and homing to liver are reviewed. A literature review was performed on primary biliary cirrhosis (PBC), progressive sclerosing cholangitis (PSC), and homing mechanisms; a total of 130 papers were selected for discussion. Available data suggest that in addition to a specific role for CCL25 in PSC, the CC chemokines CCL21 and CCL28 and the CXC chemokines CXCL9 and CXCL10 are involved in the recruitment of T lymphocytes into the portal tract in PBC and PSC. Once entering the liver, lymphocytes localize to bile duct and retain by the combinatorial or sequential action of CXCL12, CXCL16, CX3CL1, and CCL28 and possibly CXCL9 and CXCL10. The relative importance of these chemokines in the recruitment or the retention of lymphocytes around the bile ducts remains unclear. The available data remain limited but underscore the importance of recruitment and homing