Elektronik Portfolyo Uygulamalarının Ortaokul 6. Sınıf Öğrencilerinin Araştırma Becerilerine Etkisi

The purpose of this study is to examine the effect of electronic portfolio applications on 6th graders’ research skills. Exploratory design, one of the mixed methods in which qualitative and quantitative techniques are both used, was employed in the study. Whilepretest-posttest paired control group design, one of the the quasi-experimental designs, was used for the study’s quantitative dimension; case study, one of the qualitative research designs, were used for the study’s qualitative dimension. The study group was made up of 64 6th graders attending two different public middle schools during the second semester of 2014-1015 academic year. Participants numbered 34 in the experimental group and 30 in the control group. During the process, Research Skills Teaching Program (RSTP), developed by the researcher, was administered to experimental and control groups to develop research skills. While electronic portfolio applications were carried out with the students in the experimental group, no other application was carried out with the students in the control group. The application was carried out for 10 weeks and a total of 21 periods for both of the groups. Used for the research, the electronic portfolio portal was developed by web design specialists after the researcher defined the process. While the study’s quantitative data were collected by Research Skills Test qualitative data were collected by Semi-Structured Interview Form. The data obtained from the study’s quantitative dimension were analyzed with Independent Samples T-Test and Paired Samples T-Test. For the qualitative dimension of the study, the data obtained through interviews were analyzed using content analysis method. The quantitative findings obtained at the end of the study reveal that RSTP increased the research skills of students in the control group. In addition, research findings reveal that research skills education based on electronic portfolio applications increased the experimental group students’ level of using research skills significantly compared to control group students. Qualitative findings obtained at the end of the study support the quantitative findings. Qualitative findings showed that electronic portfolio applications were effective on development of students’ research skills and students’ attitudes and interests towards research.Bu araştırmanın amacı, elektronik portfolyo uygulamalarının ortaokul 6. sınıf öğrencilerinin araştırma becerileri üzerindeki etkisini incelemektir. Araştırmada, nitel ve nicel tekniklerin kullanıldığı karma yöntemlerden “Açıklayıcı Desen” kullanılmıştır. Araştırmanın nicel boyutunda yarı-deneysel modellerden ön test - son test eşleştirilmiş kontrol gruplu modelden, nitel boyutunda ise nitel araştırma modellerinden biri olan durum çalışmasından yararlanılmıştır. Araştırmanın çalışma grubunu, 2014-2015 eğitim-öğretim yılının ikinci yarıyılında, iki ayrı devlet ortaokulunun 6. sınıfına devam eden öğrenciler oluşturmuştur. Araştırma deney grubunda 34, kontrol grubunda ise 30 öğrenci olmak üzere toplam 64 öğrenciyle yürütülmüştür. Deney ve kontrol grubuna süreç boyunca araştırma yapma becerilerini geliştirmek için araştırmacı tarafından hazırlanan Araştırma Becerileri Öğretim Programı (ABÖP) uygulanmıştır. Eğitim süreci boyunca deney grubunda yer alan öğrencilerle elektronik portfolyo uygulamaları yürütülürken, kontrol grubundaki öğrencilerle başka bir uygulama yapılmamıştır. Uygulama her iki grupta da 10 hafta ve toplam 21 ders saati olarak yürütülmüştür. Araştırma kapsamında kullanılan elektronik portfolyo portalı, araştırmacının süreci tanımlamasından sonra web tasarımı uzmanları tarafından geliştirilmiştir. Araştırmanın nicel verileri Araştırma Becerileri Testi ile nitel veriler ise Yarı Yapılandırılmış Görüşme Formu ile toplanmıştır. Araştırmanın nicel boyutunda elde edilen veriler Bağımsız Örneklemler t-testi ve İlişkili Ölçümler t-testi, nitel boyutu için yapılan görüşmeler sonucunda toplanan veriler ise içerik analizi yöntemiyle çözümlenmiştir. Araştırma sonunda elde edilen nicel bulgular, ABÖP’nın kontrol grubundaki öğrencilerin araştırma becerilerini kullanma düzeylerini arttırdığını ortaya koymaktadır. Ayrıca araştırma bulguları elektronik portfolyo uygulamalarına dayalı araştırma becerileri eğitiminin deney grubundaki öğrencilerin bu becerileri kullanma düzeylerini kontrol grubunda bulunan öğrencilere göre manidar düzeyde arttırdığını ortaya koymaktadır. Araştırma sonucunda elde edilen nitel bulgular da nicel bulguları destekler niteliktedir. Nitel bulgular da elektronik portfolyo uygulamalarının öğrencilerin hem araştırma yapma becerilerinin gelişimi üzerinde hem de araştırma yapmaya yönelik tutum ve ilgileri üzerinde etkili olduğu sonucuna ulaşılmıştır

The relationship between insulin resistance, metabolic syndrome and nonalcoholic fatty liver disease in non-obese non-diabetic Turkish individuals: a pilot study

Background/Aims: Nonalcoholic fatty liver disease is related to obesity, metabolic syndrome, and insulin resistance. Nonalcoholic fatty liver disease and metabolic syndrome may also be encountered in non-obese, non-diabetic individuals, and there are no published data about the prevalence of these conditions in non-obese, non-diabetic Turkish subjects. We aimed to determine the difference between non-obese, non-diabetic nonalcoholic fatty liver disease patients and healthy controls in terms of insulin resistance and metabolic syndrome in Turkish subjects. Materials and Methods: Non-obese, non-diabetic individuals (n=219) were enrolled. The cohort was divided into two groups according to presence of steatosis in ultrasonography: nonalcoholic fatty liver disease group (n=143) and healthy control group (n=76). Insulin resistance and metabolic syndrome were analyzed and compared between the two groups. Results: The prevalences of metabolic syndrome (32.2% vs. 5.3%, respectively; p<0.001) and insulin resistance (46.2% vs. 9.2%, respectively; p<0.001) were significantly higher in the nonalcoholic fatty liver disease group. According to multiple logistic regression analysis, age (odds ratio 1.534; p=0.0032), insulin resistance (odds ratio 1.074; p<0.001), and serum ALT levels (odds ratio 1.102; p<0.001) were independently associated with nonalcoholic fatty liver disease. Conclusion: Insulin resistance and metabolic syndrome are not rare in non-obese, non-diabetic Turkish subjects with nonalcoholic fatty liver disease. Ultrasonographically detected fatty liver was independently associated with insulin resistance, irrespective of the presence of metabolic syndrome

Diyabetik Bir Olguda Orbital Sellülitin Nadir Bir Komplikasyonu: Kavernöz Sinüs Trombozu

Diyabetin çeşitli enfeksiyonlara ve tromboza eğilimi artırdığı iyi bilinmektedir. Diyabette doğal, hücresel ve humoral bağışıklık mekanizmalarının çeşitli basamaklarında bozukluklar beklenir. Trombosit fonksiyonlarındaki, koagülasyon faktörlerindeki ve damar yapısındaki bozukluklar da tromboza eğilimi artırır. Hem enfeksiyonların hem de trombotik olayların diyabetteki seyri diyabetik olmayan olgulara göre daha ciddidir. Bu yazıda orbital sellülit gelişip kavernöz sinüs trombozu ile komplike olan 94 yaşında diyabetik erkek olgu sunuldu. Olgu orbital sellülit, idrar yolu enfeksiyonu, hiperozmolar non ketotik durum, akut böbrek yetersizliği ve üremiye sekonder kompanse metabolik asidoz tanıları ile endokrinoloji servisine yatırıldı. Antibiyoterapisine ve hidrasyonuna vakit kaybetmeksizin başlanıp gerekli tedavisi yapılan olgu, mortalitesi yüksek kavernöz sinüs trombozu sonrası tedaviye cevap vermeyerek kaybedildi. Özellikle diyabetik olgularda orbital enfeksiyonların komşuluk yoluyla kavernöz sinüse yayılıp septik tromboza yol açarak ölümcül seyredebileceği göz önüne alınarak erken tanı ve tedavisi yapılmalıdırIt is that diabetes mellitus increases tendency to develop infections and thrombosis. Impairment of various mechanisms and agents of humoral and cellular immune systems can be expected. Disturbances of platelet function, coagulation factors, and vascular structure predispose diabetics to thrombotic events. The course of both infections and thrombotic events is often worse than in non-diabetic patients. Presently described is 94-year-old male patient with diabetes who had orbital cellulitis that became complicated with cavernous sinus thrombosis (CST). He was admitted to endocrinology clinic with diagnoses of orbital cellulitis, urinary tract infection, hyperosmolar non-ketotic state, acute renal failure, and compensated metabolic acidosis secondary to uremia. Despite immediate antibiotherapy, hydration, and additional required treatment, patient did not respond and died as a result of CST. There must be awareness, especially for diabetic patients, that orbital infections may spread to nearby cavernous sinuses and cause potentially lethal septic CST. Early diagnosis and immediate treatment are essentia

Wpływ dystrybucji tkanki tłuszczowej oraz wybranych adipokin na insulinooporność w stanie przedcukrzycowym

  Introduction: The risk of developing insulin resistance and metabolic syndrome is particularly high in central obesity. In this study we evaluated the effects of fat distribution and some adipokines on insulin resistance in prediabetic patients. Material and methods: Eighty-seven age- and sex-matched patients were divided into three groups according to their 75-gram oral glucose tolerance test results as follows: impaired fasting glucose group, impaired glucose tolerance group, and normal glucose tolerance group. Fasting insulin levels were measured. Homeostatic model assessment of insulin resistance was calculated. Body fat mass measurements were assessed by bioelectric impedance analyser and abdominal fat thicknesses (subcutaneous, visceral, and preperitoneal) by ultrasonography. The fasting serum levels of several adipokines [adiponectin, leptin, resistin, vaspin, visfatin, retinol-binding protein-4 (RBP-4), tumour necrosis factor-alpha (TNF-alpha)] were measured by ELISA method. Results: The mean body mass index, fat mass measurements, and abdominal fat thicknesses of the groups were similar. There were no differences between groups in terms of the mean fasting insulin, vaspin, RBP-4, leptin, resistin, and TNF-alpha. In comparison of the prediabetic and normal groups, the levels of adiponectin (p &lt; 0.001) and visfatin (p &lt; 0.001) were lower in the prediabetic group. Furthermore, we found that high body mass index (p &lt; 0.01) and fat mass (p &lt; 0.01) and low adiponectin (p &lt; 0.05) levels have roles in the development of insulin resistance in the prediabetic group. Conclusions: We suggested that in the prediabetic period not only obesity but also decreased adiponectin levels play some role in the pathogenesis of insulin resistance. (Endokrynol Pol 2016; 67 (3): 277–282)    Wstęp: Ryzyko rozwoju insulinooporności i zespołu metabolicznego zwiększa się zwłaszcza u osób z otyłością centralną. W niniejszym badaniu oceniono wpływ dystrybucji tkanki tłuszczowej i wybranych adipokin na insulinooporność u osób ze stanem przedcukrzycowym. Materiał i metody: Osiemdziesięciu siedmiu chorych dobranych pod względem wieku I płci podzielono na 3 grupy w zależności od wyniku testu doustnego obciążenia 75 g glukozy: osoby z nieprawidłową glikemią na czczo, osoby z nieprawidłową tolerancją glukozy i osoby z prawidłową tolerancją glukozy. Zmierzono stężenie insulin na czczo. Do oszacowania insulinooporności zastosowano model homeostazy. Masę tkanki tłuszczowej oceniono za pomocą analizatora bioimpedancji elektrycznej, a grubość brzusznej tkanki tłuszczowej (podskórnej, trzewnej i przedotrzewnowej) zmierzono metodą ultrasonograficzną. Stężenie na czczo w surowicy kilku adipokin (adiponektyna, leptyna, rezystyna, waspina, wisfatyna, białko wiążące retinol-4 [RBP-4], czynnik martwicy nowotworów alfa [TNF-alfa]) zmierzono, stosując metodę ELISA. Wyniki: Średni wskaźnik masy ciała, masa tkanki tłuszczowej I grubość brzusznej tkanki tłuszczowej były podobne we wszystkich grupach. Nie stwierdzono różnic między grupami pod względem średniego stężenia insuliny na czczo ani stężeń waspiny, RBP-4, leptyny, rezystyny i TNF-alfa. W porównaniu grup ze stanem cukrzycowym i grupy z prawidłową tolerancją glukozy wykazano, że stężenia adiponektyny (p &lt; 0,001) i wisfatyny (p &lt; 0,001) były niższe u osób ze stanem przedcukrzycowym. Ponadto stwierdzono, że wysoki wskaźnik masy ciała (p &lt; 0,01) i duża masa tkanki tłuszczowej (p &lt; 0,01) oraz niskie stężenie adiponektyny (p &lt; 0,05) przyczyniają się do rozwoju insulinooporności u osób ze stanem przedcukrzycowym. Wnioski: Autorzy sugerują, że nie tylko otyłość, ale również obniżenie stężenia adiponektyny odgrywają pewną rolę w patogenezie insulinooporności w okresie przedcukrzycowym. (Endokrynol Pol 2016; 67 (3): 277–282)

A Case of Pyridoxine Dependent Epilepsy Presented with Status Epilepticus

Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive encephalopathy due to mutations in the ALDH7A1 gene. Intractable seizures are the most frequent clinical form in the early infantile period. A case of a 4-month-old female patient presented to our hospital with status epilepticus. Her seizures started in the neonatal period and partial response to phenobarbital was seen. Her seizures could not be controlled with appropriate antiepileptic treatment. The seizure stopped with 100 mg of intravenous pyridoxine administration. The diagnosis of PDE was considered and ALDH7A1 gene mutation analysis revealed homozygous missense mutation. Pyridoxine should be administrated in case of intractable seizures and should be included in status epilepticus treatment protocol. Diagnosis of PDE should be considered especially in our country where consanguineous marriage is frequently seen

Real-life experiences with galcanezumab and predictors for treatment response in Turkey

BackgroundThe complexity of clinical practice extends far beyond the controlled settings of trials, and there is a need for real-world studies aimed at identifying which patients will respond to anti-CGRP monoclonal antibodies in different countries. This study aimed to investigate the efficacy and safety of galcanezumab in treating migraine in a real-life setting in Turkey, as well as identify predictors of treatment response.MethodsA total of 476 patients who diagnosed with migraine according to ICHD-3 criteria and treated with galcanezumab by headache specialists were voluntarily participated in this cross-sectional study. Galcanezumab is indicated for the prevention of migraine in adults who have at least 4 monthly migraine days in Turkey. All patients filled out a survey on Google Form that comprised 54 questions, addressing various aspects such as demographics, migraine characteristics, previous use of acute symptomatic medication, failures with preventive drug classes, comorbidities, most bothersome symptoms, as well as the interictal burden of migraine.ResultsAmong the participants, 89.3% reported that galcanezumab treatment was beneficial for them. A decrease in the frequency (80.0%), severity (85.7%), and acute medication usage for migraine attacks (71.4%) was reported with galcanezumab treatment. An adverse effect related to galcanezumab was reported in 16.3% of cases, but no serious adverse reactions were observed. Remarkably, 14.3% of participants reported no longer experiencing any headaches, and 18.9% did not require any acute treatment while receiving galcanezumab treatment. A logistic regression model showed that male gender, lack of ictal nausea, and previous failure of more than 2 prophylactic agents may predict the non-responders.ConclusionsThe first large series from Turkey showed that galcanezumab treatment is safe and effective in most of the patients diagnosed with migraine by headache experts in the real-life setting. Patients reported a significant decrease in both ictal and interictal burden of migraine and expressed satisfaction with this treatment

Methods of Blackberry Propagation in vitro Condition

Blackberry, one of the most important fruit species belonging to the Rosaceae family, can be grown in different environments due to having wide adaptation ability. Although it originated in Europe, today most of the common cultivars have North American origin. Also, expansion of its production last 25 years especially in Europe and the USA, the blackberry has become the fourth berry in the fresh berry market after strawberries, blueberries, and raspberries. Blackberry fruits are rich in vitamins, polyphenols, minerals, and antioxidants, especially gallic acid and routine. Many studies have proven that high nutritional composition has a positive effect on human health in preventing various diseases. It has an important place in the fresh and processed market. Frozen fruits can be used processed such as an ice cream, juice, jam, marmalade, cake, and sweet products. Blackberry breeding studies have been ongoing for over 100 years to increase yield and fruit quality, thornless cane, to improve disease insect resistance, and cane management and primocane fruiting. In vitro propagation is an alternative method to introduce new cultivars quickly into the market and to provide disease-free planting material compared with traditional methods. The purpose of this study was to summarize blackberry propagation methods in vitro conditions

The Examination of Reliability of Vee Diagrams According to Classical Test Theory and Generalizability Theory

The aim of this study was to investigate reliability of score obtained from vee diagrams. Therefore in this study, the Classical test theory and generalizability theory were used. The study was carried out with descriptive research model. The participants of this research were composed of 32 students at 7th and 8th grades in Niğde. The responses given to the vee diagrams were scored through the holistic rubric. In CTT, Cronbach’s alpha reliability coefficient and Kendall’s concordance coefficient for interrater reliability; in G theory, Ep2 (G) and Ф (Phi) coefficients with univariate model were computed. The Cronbach alpha reliability coefficients estimated were 0,77, 0,76, and 0,76 for each rater, respectively. For determination of interrater consistency, Kendall’s concordance coefficient was calculated as W=0,959 for the first vee diagram, W= 0,924 for the second one, W=0,963 for the third one, W=0,954 for the fourth one. For the purpose of estimating variances and percent of variances in G study, fully crossed design was applied. Generalizability coefficient for vee diagram scores was 0,918 and phi coefficient was 0,899. As a result of the G study, it was determined that the variance component estimated for the student (s) main effect accounted for 42,4% of the total variance, and it was the variance component that had the highest value. The variance component estimated for raters (p) main effect, which is the lowest variance component in all main effect, accounted for 0,1% of the total variance. According to all results, it was seen that vee diagram was reliable for determination of students’ mathematics achievement

In-vitro neural network studies

Çevresel sinir sistemi periferdeki doku organ ve uzuvlarla merkezi sinir sistemi arasında bir köprü oluşturur ve dokunma, basınç, ağrı, sıcaklık, kaşıntı, kas uzunluğu, organ hacmi gibi hissedilen çeşitli içsel ve çevresel ipuçları hakkında duyumları iletir. Arka kök gangliyonu belirli uyaranlara yanıt vermek üzere özelleşmiş primer duyusal nöronları içerir. Klasik olarak, periferal sistemin bir kablo gibi çevresel verileri ilettiği, bu esnada AKG gövdesinin yalnızca iletken aksonu destekleyen bir metabolik depo olarak hizmet ettiği düşünülmekteydi. Son yıllarda, gösterilen bulgular, kronik ağrıdaki rolü bilinen AKG dokusunun nöro-modülasyon tedavisi için uygun bir hedef olduğunu düşündürmektedir. Bu tez kapsamında görüntüleme, elektriksel uyarı, elektriksel kayıt, kalsiyum görüntüleme ve hasar modelleri kullanılarak nöral ve glial AKG hücrelerinin in-vitro devre özellikleri araştırıldı. Bu çalışma özetle, in-vitro şartlarda, AKG nöronlarının ekim yoğunluğunun nöral hayatta kalımı etkilediğini, AKG nöronlarının kültür ortamında glutamaterjik sinapslar yaptığını, ayrıca hasar yanıtının uzak bölgelere satellitik glial hücre ağı aracılığıyla taşındığını göstermiştir. AKG nöronları arasında daha önce tanımlanmamış yeni tipte bağlantılara dikkat çeken bu çalışma, nöropatilerden, fibromiyalji, hayalet uzuv ağrısı immün aracılı hiperaljezi gibi periferik sinir sisteminin gizemli ağrı sendromlarına yaklaşımımıza yeni bir ışık tutabilir.The peripheral nervous system forms a bridge between the peripheral tissue, organs, limbs, and the central nervous system and transmits sensations about various internal and environmental cues felt such as touch, pressure, pain, temperature, itching, muscle length and organ volume. The dorsal root ganglion contains primary sensory neurons specialized to respond to certain stimuli. Classically, it was thought that the peripheral system transmits environmental data like a cable, while the DRG soma was thought to serve only as a metabolic depot supporting the long conducting axon. Recent findings suggest that DRG tissue, is a suitable target for neuromodulation therapy. In this thesis, in-vitro circuit properties of neural and glial DRG cells were investigated using imaging, electrical stimulation, electrical recording, calcium imaging and injury models. In summary, this study showed that the plating density of DRG neurons affects survival under in vitro conditions, that DRG neurons make glutamatergic synapses in culture, and that the injury response is propagated to distant sites in-vitro, via a network of peripheral satellit glial cells. Highlighting new types of previously unidentified connections between DRG neurons, this study may shed new light on our approach to mysterious pain syndromes of the peripheral nervous system, such as neuropathies, fibromyalgia, phantom limb pain, immune-mediated hyperalgesia and many more

Benefits of environmental management systems implementation for companies: A case study

Bu çalışmada, Uluslar arası Standartlar Organizasyonu (ISO) tarafından geliştirilen ISO 14001 standardı incelenerek, belgelendirmenin işletmelere sağladığı faydalar değerlendirilmiştir. Bu amaçla, Çukurova bölgesinde faaliyet gösteren ISO 14001 uygulamalarını gerçekleştirmiş bir işletme ele alınmıştır. İncelenen işletmede ISO 14001 Standardının uygulanmasıyla, çevresel, ekonomik ve yönetimsel performanslar açısından olumlu değişimler sağlandığı belirlenmiştir. Ayrıca, incelenen işletmede yapılan anket ile belgelendirmenin işletmeye sağladığı faydalar çalışanların bakış açısı ile ortaya konmuştur.In this study, ISO 14001 Standard developed by International Organization for Standardization (ISO) was investigated and the benefits of certification in the companies were assessed. In order to achieve that goal, a company in Çukurova, implemented ISO 14001 system and certified was studied. It was found that the implementation of ISO 14001 standard in the company has provided benefits in terms of environmental, economic and organizational performance. In addition of these, the article provides an overview of the results of survey carried out in the company of views of the employee about benefits of certification