Numerical simulation and experimental study of electrostatic field near man with protective polymeric clothing

In the article the mathematical model and the method of numerical calculation, based on the method of finite elements of three-dimensional electrostatic field near-by a man at presence of surface charge on his protective clothing, made from polymeric material, were considered. Experimental researches were conducted to determine the value of the surface charge. The results of numeral calculations of the distribution of electric potential and field intensity, as well as integral value of electric energy, stored in this field, were presented

Gilteritinib or chemotherapy for relapsed or refractory FLT3-mutated AML

BACKGROUND: Patients with relapsed or refractory acute myeloid leukemia (AML) with mutations in the FMS-like tyrosine kinase 3 gene (FLT3) infrequently have a response to salvage chemotherapy. Gilteritinib is an oral, potent, selective FLT3 inhibitor with single-agent activity in relapsed or refractory FLT3-mutated AML. METHODS: In a phase 3 trial, we randomly assigned adults with relapsed or refractory FLT3-mutated AML in a 2:1 ratio to receive either gilteritinib (at a dose of 120 mg per day) or salvage chemotherapy. The two primary end points were overall survival and the percentage of patients who had complete remission with full or partial hematologic recovery. Secondary end points included event-free survival (freedom from treatment failure [i.e., relapse or lack of remission] or death) and the percentage of patients who had complete remission. RESULTS: Of 371 eligible patients, 247 were randomly assigned to the gilteritinib group and 124 to the salvage chemotherapy group. The median overall survival in the gilteritinib group was significantly longer than that in the chemotherapy group (9.3 months vs. 5.6 months; hazard ratio for death, 0.64; 95% confidence interval [CI], 0.49 to 0.83; P\u3c0.001). The median event-free survival was 2.8 months in the gilteritinib group and 0.7 months in the chemotherapy group (hazard ratio for treatment failure or death, 0.79; 95% CI, 0.58 to 1.09). The percentage of patients who had complete remission with full or partial hematologic recovery was 34.0% in the gilteritinib group and 15.3% in the chemotherapy group (risk difference, 18.6 percentage points; 95% CI, 9.8 to 27.4); the percentages with complete remission were 21.1% and 10.5%, respectively (risk difference, 10.6 percentage points; 95% CI, 2.8 to 18.4). In an analysis that was adjusted for therapy duration, adverse events of grade 3 or higher and serious adverse events occurred less frequently in the gilteritinib group than in the chemotherapy group; the most common adverse events of grade 3 or higher in the gilteritinib group were febrile neutropenia (45.9%), anemia (40.7%), and thrombocytopenia (22.8%). CONCLUSIONS: Gilteritinib resulted in significantly longer survival and higher percentages of patients with remission than salvage chemotherapy among patients with relapsed or refractory FLT3-mutated AML. (Funded by Astellas Pharma; ADMIRAL ClinicalTrials.gov number, NCT02421939.)

Numerical simulations of dielectric properties of composite material with periodic structure

Results of computer simulations and measurements of frequency-dependent dielectric properties of a binary composite material are presented. The studied composite had well-defined 3D periodic structure and was made of paraffin and paper laminate. In the considered frequency range (10(-3) 10(3) Hz), both the constituents were characterized by significantly different dispersive properties of complex dielectric permittivities. These frequency-dependent parameters were measured and were used for 3D numerical simulations of the effective dielectric properties of the mixture. The simulations were performed using two methods, the finite-volume method and the finite-element method. Frequency variations of the computed effective complex permittivity of the composite are discussed and are compared with the experimental data. The results of the simulations show that the distributions of the micro-scale electric field and dielectric losses in the volume of the composite material are strongly frequency dependent. This effect is also analyzed using classical models for composite dielectric structures

Dielectric Properties of Composite Structures: 3D Simulations versus Experiments

Results of numerical simulations of the dielectric properties of binary composites with three-dimensional structures are verified by means of comparison with experimentally obtained data. Two different heterogeneous structures - regular (periodic) and stochastic, were studied. Frequency dependencies of the complex dielectric permittivities of the materials of the constituent phases of the composites were measured and were used as input for computer modelling together with their known geometrical parameters. Calculations were based on the effective media approach, and the associated field problem was solved numerically using the finite-volume method and the finite-element method. The results of the measurements and the computations of the effective complex permittivities of the composite materials are compared and are analysed

Чисельне моделювання та експериментальне дослідження електростатичного поля поблизу людини із захисним полімерним одягом

This is a pre-print of an article published in “Universal Journal of Electrical and Electronic Engineering, Vol. 5(1)”. The final authenticated version is available online at: http://dx.doi.org/10.13189/ujeee.2017.050103.У статті розглянуто математичну модель та метод чисельного розрахунку електростатичного поля поруч людини за наявності поверхневого заряду на його захисному одязі, виготовленого з полімерного матеріалу, заснований на методі скінченних елементів тривимірного. Для визначення величини поверхневого заряду виконано експериментальні дослідження. Представлено результати чисельних розрахунків розподілу електричного потенціалу та напруженості поля, а також інтегрального значення електричної енергії, що накопичується в полі.In the article the mathematical model and the method of numerical calculation, based on the method of finite elements of three-dimensional electrostatic field near-by a man at presence of surface charge on his protective clothing, made from polymeric material, were considered. Experimental researches were conducted to determine the value of the surface charge. The results of numeral calculations of the distribution of electric potential and field intensity, as well as integral value of electric energy, stored in this field, were presented.В статье рассмотрены математическая модель и метод численного расчета трехмерного электростатического поля вблизи человека при наличии поверхностного заряда на его защитной одежде из полимерного материала, основанный на методе конечных элементов. Проведены экспериментальные исследования по определению величины поверхностного заряда. Приведены результаты численных расчетов распределения электрического потенциала и напряженности поля, а также интегрального значения электрической энергии, запасенной в этом поле

Dielectric Properties of Composite Structures: 3D Simulations versus Experiments

Results of numerical simulations of the dielectric properties of binary composites with three-dimensional structures are verified by means of comparison with experimentally obtained data. Two different heterogeneous structures - regular (periodic) and stochastic, were studied. Frequency dependencies of the complex dielectric permittivities of the materials of the constituent phases of the composites were measured and were used as input for computer modelling together with their known geometrical parameters. Calculations were based on the effective media approach, and the associated field problem was solved numerically using the finite-volume method and the finite-element method. The results of the measurements and the computations of the effective complex permittivities of the composite materials are compared and are analysed

Numerical calculation of electric fields, losses and interfacial charge densities in water-treed dielectric composite structure

Results of the computer modeling and an analysis of electrical processes in a water-treed polyethylene (XLPE) are presented. The water-treed region is considered as a binary composite structure in frequency domain. Electric fields, energy losses and interfacial charge densities are calculated and are examined using a simplified layered model and 3D model of a real water-treed XLPE insulation. It is shown that the interfacial charges in the bulk of the composite structure build up mostly due to differences in conductive properties of the constituent phases, and the distributions of the electric fields and losses are determined also by the morphology of the water-treed region