Formal features as a design factor of video segments in interactive video programmes

Video segments may be characterized by formal design features with respect to factors such as complexity of narration, mutual influence of picture and sound, use of superimposed texts, information load due to technical terms, and animation. The paper suggests ways to operationalize these factors and reports about an experiment in which the influence of these formal features was studied with respect to perceived information load of video segments by learners. The length of a segment was thereby counted as the number of information elements it contains. An information element is defined as one uninterrupted statement of the narrator about which one factual question can be presented. The experiment was carried out by using an experimental videodisc programme about cheesemaking that contains 252 information elements which form a connected discourse of 36 min if the programme is played linearly without stopping. Subjects had the task to divide this programme into segments by deciding for themselves how often they would stop before completing the programme. At every stopping place, the subjects were questioned about the content of the just completed segment.\ud \ud The results of the experiment suggest that: (a) subjects tend to perceive narrated sentences as one whole, regardless of the number of facts implied, (b) content-related technical terms seem not to determine difficulty level, (c) superimposed texts show a trend to help subjects who prefer short segments to choose longer segments and subjects who prefer long segments to choose shorter segments, (d) animation is positively (but moderately) correlated with mean self-chosen segment length

Video outside versus video inside the web: do media setting and image size have an impact on the emotion-evoking potential of video?

To explore the educational potential of video-evoked affective responses in a Web-based environment, the question was raised whether video in a Web-based environment is experienced differently from video in a traditional context. An experiment was conducted that studied the affect-evoking power of video segments in a window on a computer screen compared to presenting the same video materials on a television monitor. The study first demonstrates that affect-evoking power of video exists. Although not always significant, the results who that selected positive and negative video clips induce positive or negative affective responses and mood changes in participants, in a Web-based environment as well as in a television environment. Smaller window sizes, however, may do less well

Essais de rationnement de boucs de la race rousse de Maradi avec des sous-produits de l'agriculture locale (Niger)

L'auteur montre qu'il est possible d'assurer l'entretien ou la croissance de boucs de cette race, en fin de saison sèche alors que les pâturages naturels ont pratiquement disparu, en les alimentant exclusivement avec des sous-produits de l'agriculture locale: graines de coton, fanes sèches de Niebé, son de mil, tourteau d'arachide, avec des rations dont il donne la composition et le prix de revien

Experiences and Attitudes of Genome Investigators Regarding Return of Individual Genetic Test Results

Purpose Whether and how to return individual genetic results to study participants is among the most contentious policy issues in contemporary genomic research. Methods: We surveyed corresponding authors of genome-wide association studies (GWAS), identified through the National Human Genome Research Institute's Catalog of Published GWAS, to describe the experiences and attitudes of these stakeholders. Results: Of 357 corresponding authors, 200 (56%) responded. One hundred twenty-six (63%) had been responsible for primary data and sample collection, whereas 74 (37%) had performed secondary analyses. Only 7 (4%) had returned individual results within their index GWAS. Most (69%) believed that return of results to individual participants was warranted under at least some circumstances. Most respondents identified a desire to benefit participants's health (63%) and respect for participants's; desires for information (57%) as major motivations for returning results. Most also identified uncertain clinical utility (76%), the possibility that participants will misunderstand results (74%), the potential for emotional harm (61%), the need to ensure access to trained clinicians (59%), and the potential for loss of confidentiality (51%) as major barriers to return. Conclusion: Investigators have limited experience returning individual results from genome-scale research, yet most are motivated to do so in at least some circumstances

Optimizing the identification of risk-relevant mutations by multigene panel testing in selected hereditary breast/ovarian cancer families

The introduction of multigene panel testing for hereditary breast/ovarian cancer screening has greatly improved efficiency, speed, and costs. However, its clinical utility is still debated, mostly due to the lack of conclusive evidences on the impact of newly discovered genetic variants on cancer risk and lack of evidence-based guidelines for the clinical management of their carriers. In this pilot study, we aimed to test whether a systematic and multiparametric characterization of newly discovered mutations could enhance the clinical utility of multigene panel sequencing. Out of a pool of 367 breast/ovarian cancer families Sanger-sequenced for BRCA1 and BRCA2 gene mutations, we selected a cohort of 20 BRCA1/2-negative families to be subjected to the BROCA-Cancer Risk Panel massive parallel sequencing. As a strategy for the systematic characterization of newly discovered genetic variants, we collected blood and cancer tissue samples and established lymphoblastoid cell lines from all available individuals in these families, to perform segregation analysis, loss-of-heterozygosity and further molecular studies. We identified loss-of-function mutations in 6 out 20 high-risk families, 5 of which occurred on BRCA1, CHEK2 and ATM and are esteemed to be risk-relevant. In contrast, a novel RAD50 truncating mutation is most likely unrelated to breast cancer. Our data suggest that integrating multigene panel testing with a pre-organized, multiparametric characterization of newly discovered genetic variants improves the identification of risk-relevant alleles impacting on the clinical management of their carriers

Pediatric Cancer Genetics Research and an Evolving Preventive Ethics Approach for Return of Results after Death of the Subject

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115941/1/jlme12295.pd