Follow-Up Imaging of Inflammatory Myofibroblastic Tumor of the Uterus and Its Spontaneous Regression

Inflammatory myofibroblastic tumor (IMT) is an aggressive benign mass that may arise from various tissues and organs with a great variability of histological and clinical appearances. Due to variable and nonspecific imaging findings, diagnosis of IMT is not obtained before surgery. The aim of this paper is to present CT and MRI findings during four-year follow-up of complete, spontaneous regression of IMT of the uterus. The diagnosis was made by histology and immunohistochemistry analysis of the open excisional biopsy specimen. At that time, the organ of origin was not specified. After analysis of the follow-up imaging findings and the mode of tumor regression, the uterus was proclaimed as the probable site of origin. IMT of the uterus is extremely rare and has been reported in ten cases up to now. The gradual, complete regression of uterine IMT documented by CT and MRI may contribute to understanding of its nature

Effects of radiotherapy on oral cavity tissues

Radiotherapy in the treatment of head and neck tumors is most often used as an independent method or in combination with surgery and / or chemotherapy. These therapeutic methods in a multidisciplinary approach generally lead to favourable therapeutic response. During radiotherapy of this region, oral mucosa is inevitably covered within irradiated volume. Radical therapy is achieved with high doses of radiation, which usually results in development of undesired toxic effects, which, depending on the time of manifestation can be acute and late. Acute radiation toxicity occurs during or immediately after completion of performed therapy, and the late one several months or years after the completed treatment. The most common acute complications in the oral cavity are inflammation of oral mucosa, loss of taste, dry mouth and secondary infections. Late complications include radiation caries, trismus, and osteoradionecrosis. The aim of this paper was to present the effects and specificities of toxicity observed on oral cavity tissues after radiotherapy

Pojava recidiva karcinoma rektuma u odnosu na pol ispitanika

Colorectal cancer is the most frequent gastrointestinal tumor, very often situated in the rectum. Serbia is for long period of time in group of European countries with average incidence and high mortality of rectal cancer. Aim: To investigate if histopathological type and grade of cancer and time before local recurrence depend on patients' sex, considering that rectal cancer is more often present in male than in female. Material and methods: A retrospective study (2004‒2013.) included 49 patients from Institute for oncology and radiology in Belgrade, with locally recurrent rectal cancer (29 male and 20 female). All the patients with primary rectal cancer had surgical treatment; postoperative adjuvant chemotherapy was applied in 25 patients. Results: Mean age of our patients is 68 years (min 32, max 84 years). Recurrent rectal cancer is most frequent in group 70‒79 years, both in men and women. Adenocarcinoma is histopathological type of rectal cancer in 96% of patients. The most frequent HP grade is moderately differentiated tumor, grade II (p lt 0,0001). Local recurrences appear within two years after surgery (p=0,0109). Conclusion: We didn't establish correlation between histopathological type and grade of rectal cancer and period of local recurrence related to patients' sex. Given the prevalence of both sexes, screening of patients, adequate diagnosis and timely treatment are most important.Karcinomi debelog creva su najčešći tumori digestivnog trakta sa veoma čestom lokalizacijom u rektumu. Naša zemlja se već duži niz godina nalazi u grupi evropskih zemalja sa srednje visokim stopama obolevanja i visokim stopama smrtnosti od ovog karcinoma. Cilj: Utvrditi da li histopatološki tip i gradus karcinoma i vreme do pojave recidiva zavise od pola pacijenta, s obzirom na to da je karcinom rektuma češće prisutan kod muškaraca nego kod žena. Materijal i metode: U retrospektivnu studiju koja obuhvata period od 2004. do 2013. godine uključeno je 49 pacijenata Instituta za onkologiju i radiologiju u Beogradu sa recidivima karcinoma rektuma (29 muškaraca i 20 žena). Svi bolesnici sa primarnim karcinomom rektuma bili su operisani, a postoperativno je sprovedena adjuvantna hemioterapija kod 25 pacijenata. Rezultati: Prosečna starost naših ispitanika bila je 68 godina (najmlađi pacijent imao je 32 godine, a najstariji 84). Najveća učestalost recidiva karcinoma rektuma je u starosnoj grupi 70‒79 godina kod oba pola. Kod 96% pacijenata histopatološki tip tumora je adenokarcinom. Najčešći histopatološki gradus tumora u ispitanoj grupi je srednje diferentovani tumor, gradus II (p lt 0,0001). Recidivi su se uglavnom javljali u prve dve godine nakon operacije (p=0,0109). Zaključak: Nije utvrđena statistički značajna razlika između histopatološkog tipa i gradusa karcinoma rektuma i vremena od operacije do pojave recidiva u odnosu na pol pacijenata. S obzirom na rasprostranjenost bolesti kod oba pola zaključujemo da je radi pravovremenog lečenja najvažniji skrining pacijenata i adekvatna dijagnostika

Posterior breast cancer: Mammographic and ultrasonographic features

Background/Aim. Posterior breast cancers are located in the prepectoral region of the breast. Owing to this distinctive anatomical localization, physical examination and mammographic or ultrasonographic evaluation can be difficult. The purpose of the study was to assess possibilities of diagnostic mammography and breast ultrasonography in detection and differentiation of posterior breast cancers. Methods. The study included 40 women with palpable, histopathological confirmed posterior breast cancer. Mammographic and ultrasonographic features were defined according to Breast Imaging Reporting and Data System (BI-RADS) lexicon. Results. Based on standard two-view mammography 87.5%, of the cases were classified as BI-RADS 4 and 5 categories, while after additional mammographic views all the cases were defined as BIRADS 4 and 5 categories. Among 96 mammographic descriptors, the most frequent were: spiculated mass (24.0%), architectural distortion (16.7%), clustered microcalcifications (12.6%) and focal asymmetric density (12.6%). The differentiation of the spiculated mass was significantly associated with the possibility to visualize the lesion at two-view mammography (p = 0.009), without the association with lesion diameter (p = 0.083) or histopathological type (p = 0.055). Mammographic signs of invasive lobular carcinoma were significantly different from other histopathological types (architectural distortion, p = 0.003; focal asymmetric density, p = 0.019; association of four or five subtle signs of malignancy, p = 0.006). All cancers were detectable by ultrasonography. Mass lesions were found in 82.0% of the cases. Among 153 ultrasonographic descriptors, the most frequent were: irregular mass (15.7%), lobulated mass (7.2%), abnormal color Doppler signals (20.3%), posterior acoustic attenuation (18.3%). Ultrasonographic BI-RADS 4 and 5 categories were defined in 72.5% of the cases, without a significant difference among various histopathological types (p = 0.109). Conclusion. Standard two-view mammography followed by additional mammographic projections is an effective way to demonstrate the spiculated mass and to classify the prepectoral lesion as category BI-RADS 4 or 5. Additional ultrasonography can overcome the mimicry of invasive lobular breast carcinoma at mammography