Evaluation of the burden of HPV-related hospitalizations as a useful tool to increase awareness: 2007–2017 data from the sicilian hospital discharge records

In light of the implementation of human papillomavirus (HPV) prevention strategies, epidemiological studies in different geographical areas are required in order to assess the impact of HPV-related diseases. The purpose of the present study was to describe the burden of HPV-related hospitalizations in Sicily. A retrospective observational study estimated 43,531 hospitalizations attributable to HPV from 2007 to 2017. During the observed period, there was a decrease for all HPV-related conditions with a higher reduction, among neoplasms, for cervical cancer (annual percent change (APC) = −9.9%, p < 0.001). The median age for cervical cancer was 45 years old, with an increasing value from 43 to 47 years (p < 0.001). The age classes with greater decreases in hospital admissions for invasive cancers were women aged 35 years or more (APC range from −5.5 to −9.86) and 25–34 years old (APC = −11.87, p < 0.001) for women with cervical carcinoma in situ. After ten years for vaccine introduction and sixteen years for cervical cancer screening availability, a relatively large decrease in hospital admissions for cervical cancer and other HPV-related diseases in Sicily was observed. Some clinical characteristics of hospitalization, such as increasing age, are suggestive clues for the impact of preventive strategies, but further research is needed to confirm this relationship

Widening use of dexamethasone implant for the treatment of macular edema

Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis. The implant is formulated in a biodegradable copolymer to release the active ingredient within the vitreous chamber for up to 6 months after an intravitreal injection, allowing a prolonged interval of efficacy between injections with a good safety profile. Various other ocular pathologies with inflammatory etio­pathogeneses associated with macular edema have been treated by DEX implant, including neovascular age-related macular degeneration, Irvine–Gass syndrome, vasoproliferative retinal tumors, retinal telangiectasia, Coats’ disease, radiation maculopathy, retinitis pigmentosa, and macular edema secondary to scleral buckling and pars plana vitrectomy. We undertook a review to provide a comprehensive collection of all of the diseases that benefit from the use of the sustained-release DEX implant, alone or in combination with concomitant therapies. A MEDLINE search revealed lack of randomized controlled trials related to these indications. Therefore we included and analyzed all available studies (retrospective and prospective, com­parative and non-comparative, randomized and nonrandomized, single center and multicenter, and case report). There are reports in the literature of the use of DEX implant across a range of macular edema-related pathologies, with their clinical experience supporting the use of DEX implant on a case-by-case basis with the aim of improving patient outcomes in many macular pathologies. As many of the reported macular pathologies are difficult to treat, a new treat­ment option that has a beneficial influence on the clinical course of the disease may be useful in clinical practice

The COVID-19 Wellbeing Study: Examining perceived coercion and psychological wellbeing during the COVID-19 pandemic by means of an online survey, asynchronous virtual focus groups and individual interviews – a protocol

Introduction: The COVID-19 pandemic has resulted in many countries applying restrictive measures, such as lockdown, to contain and prevent further spread. The psychological impact of lockdown and working as a healthcare worker on the frontline has been chronicled in studies pertaining to previous infectious disease pandemics that have reported the presence of depressive symptoms, anxiety, insomnia, and post-traumatic stress symptoms. Potentially linked to psychological well-being and not yet studied is the possibility that lockdown and working on the frontline of the pandemic are associated with perceptions of coercion. Methods and analysis: The present study aimed to examine perceived coercion in those who have experienced COVID-19-related lockdown and/or worked as a frontline healthcare worker across three European countries. It aimed to describe how such perceptions may impact on psychological well-being, coping and posttraumatic growth. It will employ an explanatory mixedmethods research methodology consisting of an online survey and online asynchronous virtual focus groups (AVFGs) and individual interviews. χ2 tests and analyses of variance will be used to examine whether participants from different countries differ according to demographic factors, whether there are differences between cohorts on perceived coercion, depression, anxiety and post-traumatic growth scores. The relationship between coercion and symptoms of distress will be assessed using multiple regression. Both the AVFGs and the narrative interviews will be analysed using thematic narrative analysis. Ethics and dissemination: The study has been approved by University College London’s Research Ethics Committee under Project ID Number 7335/004. Results will be disseminated by means of peer-reviewed publications and at national and/or international conferences

THE FUSION of EXTERNAL and INTERNAL 3D PHOTOGRAMMETRIC MODELS AS A TOOL to INVESTIGATE the ANCIENT HUMAN/CAVE INTERACTION: The la SASSA CASE STUDY

Caves have been used by humans and animals for several thousand years until present but, at these time scales, their structures can rapidly change due to erosion and concretion processes. For this reason, the availability of precise 3D models improves the data quality and quantity allowing the reconstruction of their ancient appearance, structure and origin. However, caves are usually characterised by lack of light, high percentage of relative humidity, narrow spaces and complex morphology. Thus, quite often the traditional topographic instruments cannot be employed. In the La Sassa cave (Sonnino, Italy) a huge deposit ranging from Pleistocene to the Second World War has been found and stratigraphic evidence suggested that the shape of the cave and its entrance might have been different. In this paper, the fusion of the internal and external 3D photogrammetric models of the La Sassa, made to support the archaeological excavations, is presented, A Nikon camera with a fisheye lens and a smartphone camera have been used to survey the internal part of the cave, while an aerial drone has been employed for the external area. The two models have been georeferenced and scaled using GCPs acquired by a double frequency GNSS (GPS and GLONASS) receiver. A low-resolution DTM derived from a previous aerial laser scanning survey and the 3D models have been elaborated in CloudCompare environment to highlight the complete morphology of the cave and its surroundings

The fusion of external and internal 3D photogrammetric models as a tool to investigate the ancient human/cave interaction:The La Sassa case study

Caves have been used by humans and animals for several thousand years until present but, at these time scales, their structures can rapidly change due to erosion and concretion processes. For this reason, the availability of precise 3D models improves the data quality and quantity allowing the reconstruction of their ancient appearance, structure and origin. However, caves are usually characterised by lack of light, high percentage of relative humidity, narrow spaces and complex morphology. Thus, quite often the traditional topographic instruments cannot be employed. In the La Sassa cave (Sonnino, Italy) a huge deposit ranging from Pleistocene to the Second World War has been found and stratigraphic evidence suggested that the shape of the cave and its entrance might have been different. In this paper, the fusion of the internal and external 3D photogrammetric models of the La Sassa, made to support the archaeological excavations, is presented, A Nikon camera with a fisheye lens and a smartphone camera have been used to survey the internal part of the cave, while an aerial drone has been employed for the external area. The two models have been georeferenced and scaled using GCPs acquired by a double frequency GNSS (GPS and GLONASS) receiver. A low-resolution DTM derived from a previous aerial laser scanning survey and the 3D models have been elaborated in CloudCompare environment to highlight the complete morphology of the cave and its surroundings

Use of the sensors of a latest generation mobile phone for the three-dimensional reconstruction of an archaeological monument: The survey of the Intihuatana stone in Machu Picchu (Peru')

The survey of archaeological monuments presents particular needs and difficulties. Such surveys must in fact be as complete, geometrically correct and accurately geo-referenced as possible. These needs, however, often face problems of difficult accessibility, the need for rapid timing and complex logistical conditions. The latest generation of mobile phones are equipped with ultra-high resolution cameras up to 100 megapixel. Although they do not have the geometric characteristics of professional cameras, they can be used advantageously for the reconstruction of three-dimensional models using Structure from Motion methodologies . At the same time, the latest mobile phones are equipped with GPS/GNSS chips that allow a postprocessing of their positioning allowing to reach decimetric/centimetric accuracies. The use of sensors integrated in a mobile phone greatly simplify the survey both in terms of transportability but also in terms of authorizations by the competent authorities as the equipment is exactly the same that most tourists who visit the sites themselves bring with them. The approach proposed and made possible by these combined features in a latest generation mobile phone have been tested for a rapid survey of the Intihuatana stone in Machu Picchu (Peru), a site with considerable logistical and organizing complexity

Use of the sensors of a latest generation mobile phone for the three-dimensional reconstruction of an archaeological monument: the survey of the Intihuatana stone in Machu Picchu (Peru’)

Abstract The survey of archaeological monuments presents particular needs and difficulties. Such surveys must in fact be as complete, geometrically correct and accurately geo-referenced as possible. These needs, however, often face problems of difficult accessibility, the need for rapid timing and complex logistical conditions. The latest generation of mobile phones are equipped with ultra-high resolution cameras up to 100 megapixel. Although they do not have the geometric characteristics of professional cameras, they can be used advantageously for the reconstruction of three-dimensional models using Structure from Motion methodologies . At the same time, the latest mobile phones are equipped with GPS/GNSS chips that allow a postprocessing of their positioning allowing to reach decimetric/centimetric accuracies. The use of sensors integrated in a mobile phone greatly simplify the survey both in terms of transportability but also in terms of authorizations by the competent authorities as the equipment is exactly the same that most tourists who visit the sites themselves bring with them. The approach proposed and made possible by these combined features in a latest generation mobile phone have been tested for a rapid survey of the Intihuatana stone in Machu Picchu (Peru), a site with considerable logistical and organizing complexity

Fisheye Photogrammetry to Survey Narrow Spaces in Architecture and a Hypogea Environment

Nowadays, the increasing computation power of commercial grade processors has actively led to a vast spreading of image-based reconstruction software as well as its application in different disciplines. As a result, new frontiers regarding the use of photogrammetry in a vast range of investigation activities are being explored. This paper investigates the implementation of fisheye lenses in non-classical survey activities along with the related problematics. Fisheye lenses are outstanding because of their large field of view. This characteristic alone can be a game changer in reducing the amount of data required, thus speeding up the photogrammetric process when needed. Although they come at a cost, field of view (FOV), speed and manoeuvrability are key to the success of those optics as shown by two of the presented case studies: the survey of a very narrow spiral staircase located in the Duomo di Milano and the survey of a very narrow hypogea structure in Rome. A third case study, which deals with low-cost sensors, shows the metric evaluation of a commercial spherical camera equipped with fisheye lenses