High temperature thermal energy storage : encapsulated phase change material particles : determination of thermal and mechanical properties

[No abstract provided

Pushing The Limits of the Wiener Filter in Image Denoising

As modern image denoiser networks have grown in size, their reported performance in popular real noise benchmarks such as DND and SIDD have now long outperformed classic non-deep learning denoisers such as Wiener and Wavelet-based methods. In this paper, we propose to revisit the Wiener filter and re-assess its potential performance. We show that carefully considering the implementation of the Wiener filter can yield similar performance to popular networks such as DnCNN.Comment: ICIP Preprin

Mechanistic studies on DNA damage by minor groove binding copper–phenanthroline conjugates

Copper–phenanthroline complexes oxidatively damage and cleave nucleic acids. Copper bis-phenanthroline and copper complexes of mono- and bis-phenanthroline conjugates are used as research tools for studying nucleic acid structure and binding interactions. The mechanism of DNA oxidation and cleavage by these complexes was examined using two copper–phenanthroline conjugates of the sequence-specific binding molecule, distamycin. The complexes contained either one or two phenanthroline units that were bonded to the DNA-binding domain through a linker via the 3-position of the copper ligand. A duplex containing independently generated 2-deoxyribonolactone facilitated kinetic analysis of DNA cleavage. Oxidation rate constants were highly dependent upon the ligand environment but rate constants describing elimination of the alkali-labile 2-deoxyribonolactone intermediate were not. Rate constants describing DNA cleavage induced by each molecule were 11–54 times larger than the respective oxidation rate constants. The experiments indicate that DNA cleavage resulting from β-elimination of 2-deoxyribonolactone by copper–phenanthroline complexes is a general mechanism utilized by this family of molecules. In addition, the experiments confirm that DNA damage mediated by mono- and bis-phenanthroline copper complexes proceeds through distinct species, albeit with similar outcomes