Maximal activities of enzymes involved in adenosine metabolism in muscle and adipose tissue of rats under conditions of variations in insulin sensitivity

AbstractThe maximal activities of 5'-nucleotidase, adenosine deaminase and adenosine kinase were measured in quadriceps or soleus muscle from animals in which the sensitivity to insulin was changed. Most conditions caused no effect on the activities but exercise-training increased the activity of adenosine deaminase and cold exposure increased the activity of 5'-nucleotidase in soleus muscle: in addition, ageing decreased markedly the activities of all three enzymes in both muscles. When the activities are based on mg protein they are much higher in both white and brown adipose tissue than in muscle, suggesting that changes in adenosine concentration may be important in changing insulin sensitivity in adipose tissue whereas changes in adenosine receptor number may be more important in muscle

Systematically Searching for New Resonances at the Energy Frontier using Topological Models

We propose a new strategy to systematically search for new physics processes in particle collisions at the energy frontier. An examination of all possible topologies which give identifiable resonant features in a specific final state leads to a tractable number of `topological models' per final state and gives specific guidance for their discovery. Using one specific final state, $\ell\ell jj$, as an example, we find that the number of possibilities is reasonable and reveals simple, but as-yet-unexplored, topologies which contain significant discovery potential. We propose analysis techniques and estimate the sensitivity for $pp$ collisions with $\sqrt{s}=14$ TeV and $\mathcal{L}=300$ fb$^{-1}$

In-Pile ⁴He Source for UCN Production at the ESS

ESS will be a premier neutron source facility. Unprecedented neutron beam intensities are ensured by spallation reactions of a 5 MW, 2.0 GeV proton beam impinging on a tungsten target equipped with advanced moderators. The work presented here aims at investigating possibilities for installing an ultra cold neutron (UCN) source at the ESS. One consequence of using the recently proposed flat moderators is that they take up less space than the moderators originally foreseen and thus leave more freedom to design a UCN source, close to the spallation hotspot. One of the options studied is to place a large He-4 UCN source in a through-going tube which penetrates the shielding below the target. First calculations of neutron flux available for UCN production are given, along with heat-load estimates. It is estimated that the flux can give rise to a UCN production at a rate of up to 1.5 . 10(8) UCN/s. A production in this range potentially allows for a number of UCN experiments to be carried out at unprecedented precision, including, for example, quantum gravitational spectroscopy with UCNs which rely on high phase-space density

Low dimensional neutron moderators for enhanced source brightness

In a recent numerical optimization study we have found that liquid para-hydrogen coupled cold neutron moderators deliver 3 - 5 times higher cold neutron brightness at a spallation neutron source if they take the form of a flat, quasi 2-dimensional disc, in contrast to the conventional more voluminous shapes used by now. In the present paper we describe a simple theoretical explanation of this unexpected behavior, which is based on the large difference in para-hydrogen between the values of the scattering mean free path for thermal neutrons (in the range of 1 cm) and its much larger equivalent for cold neutrons. This model leads to the conclusions that the optimal shape for high brightness para-hydrogen neutron moderators is the quasi 1-dimensional tube and these low dimensional moderators can also deliver much enhanced cold neutron brightness in fission reactor neutron sources, compared to much more voluminous liquid D2 or H2 moderators currently used. Neutronic simulation calculations confirm both of these theoretical conclusions.Comment: 6 pages, 2 figure

Architecture and Design of the McMaster NEUDOSE Communication Radio Subsystem

The communication subsystem is responsible for ensuring robust communication between the McMaster NEUDOSE CubeSat and the Ground Station located at McMaster University. This subsystem sends the collected scientific data, system telemetry (health), and telecommand from the onboard instruments using two different communication radio frequencies

Using ePrognosis to estimate 2-year all-cause mortality in older women with breast cancer: Cancer and Leukemia Group B (CALGB) 49907 and 369901 (Alliance A151503)

Tools to estimate survival, such as ePrognosis (http://eprognosis.ucsf.edu/carey2.php), were developed for general, not cancer, populations. In older patients with breast cancer, accurate overall survival estimates would facilitate discussions about adjuvant therapies