The anandamide analog, Met-F-AEA, controls human breast cancer cell migration via the RHOA/RHO kinase signaling pathway

n/

Self-energies in itinerant magnets: A focus on Fe and Ni

We present a detailed study of local and non-local correlations in the electronic structure of elemental transition metals carried out by means of the Quasiparticle Self-consistent GW (QSGW ) and Dynamical Mean Field Theory (DMFT). Recent high resolution ARPES and Haas-van Alphen data of two typical transition metal systems (Fe and Ni) are used as case study. (i) We find that the properties of Fe are very well described by QSGW. Agreement with cyclotron and very clean ARPES measurements is excellent, provided that final-state scattering is taken into account. This establishes the exceptional reliability of QSGW also in metallic systems. (ii) Nonetheless QSGW alone is not able to provide an adequate description of the Ni ARPES data due to strong local spin fluctuations. We surmount this deficiency by combining nonlocal charge fluctuations in QSGW with local spin fluctuations in DMFT (QSGW + 'Magnetic DMFT'). (iii) Finally we show that the dynamics of the local fluctuations are actually not crucial. The addition of an external static field can lead to similarly good results if non-local correlations are included through QSGW

Determination of n-3 index and arachidonic acid/eicosapentaenoic acid ratio in dried blood spot by gas chromatography

Background: Clinical and epidemiological studies suggest that analysis of the polyunsaturated fatty acids (PUFAs) is essential to evaluate nutritional requirements and disease risk. We describe a simple, sensitive and non-invasive method for estimating the n-3 index and arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio in dried blood spots (DBSs). Experimental: After obtaining DBSs on a spot card, PUFAs were transesterified (direct, acidic transesterification) and subsequently extracted with n-hexane. Gas chromatography with flame ionization detection (GC-FID) was used to analyze the extracted PUFAs, and then n-3 index and AA/EPA ratio were calculated. Method validation showed satisfactory precision and linearity. Conclusion: This analysis is simple and reliable to estimate PUFA status, and it was successfully applied to samples from 20 subjects, demonstrating its applicability

Nasal tip sutures: how to control shape and orientation in rhinoplasty

Nasal tip surgery is universally recognized as the most challenging part of the rhinoplasty procedure. "The tip makes the nose”. Narrowing the anatomically complex alar cartilages can lead to functional and aesthetic unfavourable outcomes. A thorough understanding of the ideal surface aesthetics and contours and spatial relationships of the structures of the nose tip is mandatory. In primary rhinoplasty, a very large percentage of visible tip deformities involve two major areas: the domes and the lateral crura. Suture techniques have the potential to modify the position, shape and definition of the tip. However, even sutures may result in changes beyond the main goals for which they are placed. The final suture effects are influenced by factors such as forces intrinsic to the cartilages, the degree of suture tightening, and limitations posed by the soft-tissue attachments. The closed delivery approach is our favourite. In a step-by-step fashion, first the medial pillar of the tripod should be addressed, establishing stable and strong tip support and basic dome projection symmetry. Subsequently and in our experience, in a standard procedure shaping lateral crura and domes, using reversible techniques that preserve structural integrity of the rimstrip, would be advisable. One of the main goals is not only to narrow the tip but to change the angle of rotation of the lateral crus surface in relation to the sagittal upper septal margin. Once marked the new dome defining point, with a variable combination of the lateral crural steal technique, sutures such as cranial tip sutures (CTS) and hemitransdomal sutures (HTS) might produce the needed outcome of everting and rotating the caudal margin of the lateral crura above the cranial edge. These sutures can gradually increase domal convexity and reduce lateral crura convexity. Additional dome equalization suture can guarantee more symmetry and then one or more lateral crural spanning sutures help in achieving supplementary eversion of the lateral crus. After establishing adequate projection, the tip rotation or position sutures are placed between the cranial edge of intermediate crura and the dorsal septum. The personal association of suture techniques is presented in this study and the long-term subjective and objective results are discussed along with the pros and cons

The challenging Silent sinus syndrome

The Silent sinus syndrome (SSS), first described in 1964 by Montgomery, is considered a relatively rare pathological entity, but it is presumably underdiagnosed and underreported. Terms such as imploding antrum and chronic maxillary atelectasis (CMA) have interchangeably been used to describe this syndrome, even though CMA has been postulated to represent either a different entity or a stage of evolution of the same disease. Bilateral involvement has been documented in a limited number of cases. Silent ethmoid sinus and silent frontal sinus syndromes have been described. The prevalent initial presentation is facial asymmetry with progressive “silent” painless unilateral enophthalmos and hypoglobus, and rarely diplopia. Isolated maxillary sinus hypoplasia must be differentiated. The etiopathogenesis is poorly understood and still under debate. According to the diagnostic criteria, SSS should spontaneously develops in absence of previous trauma or surgery. Secondary SSS to trauma or surgery, or to other causes like inflammation or tumor, has been documented in literature. The diagnosis relies on the CT, which typically shows unilateral hypoplastic and opacified maxillary sinus with inward bowing and remodeling of the sinus walls and inferior displacement of the orbital floor, an enlarged retroantral fat pad, a lateralized uncinate process, and a blocked ostiomeatal complex. The treatment of SSS aims at restoring the eye position and orbital floor height, to prevent progression of enophthalmos, to restore ventilation and drainage of the sinus. These objectives are achieved in single or two-stage surgery. The timing for management of the orbital floor is still under debate.The universally accepted treatment is surgical and usually accomplished by endoscopic sinus surgery. Associated middle turbinate hypertrophy and septal deviation must be previously addressed. Precise and gentle endoscopic removal of the obstruction of the ethmoid infundibulum, simply performing an inferior posteroanterior uncinectomy, since the uncinate process has constantly been found atelectatic and adherent to the lateral nasal wall, can reestablish the patency of the natural maxillary ostium. In our experience, following middle meatal antrostomy, long-term observation with staged orbital surgery, if required, is recommended. In this study, we present our cases with a focus on surgical stratagems developed in order to reduce the risk of injuring the orbit and to achieve long-lasting results

Nasal tip sutures: how to control shape and orientation in rhinoplasty

Nasal tip surgery is universally recognized as the most challenging part of the rhinoplasty procedure. "The tip makes the nose”. Narrowing the anatomically complex alar cartilages can lead to functional and aesthetic unfavourable outcomes. A thorough understanding of the ideal surface aesthetics and contours and spatial relationships of the structures of the nose tip is mandatory. In primary rhinoplasty, a very large percentage of visible tip deformities involve two major areas: the domes and the lateral crura. Suture techniques have the potential to modify the position, shape and definition of the tip. However, even sutures may result in changes beyond the main goals for which they are placed. The final suture effects are influenced by factors such as forces intrinsic to the cartilages, the degree of suture tightening, and limitations posed by the soft-tissue attachments. The closed delivery approach is our favourite. In a step-by-step fashion, first the medial pillar of the tripod should be addressed, establishing stable and strong tip support and basic dome projection symmetry. Subsequently and in our experience, in a standard procedure shaping lateral crura and domes, using reversible techniques that preserve structural integrity of the rimstrip, would be advisable. One of the main goals is not only to narrow the tip but to change the angle of rotation of the lateral crus surface in relation to the sagittal upper septal margin. Once marked the new dome defining point, with a variable combination of the lateral crural steal technique, sutures such as cranial tip sutures (CTS) and hemitransdomal sutures (HTS) might produce the needed outcome of everting and rotating the caudal margin of the lateral crura above the cranial edge. These sutures can gradually increase domal convexity and reduce lateral crura convexity. Additional dome equalization suture can guarantee more symmetry and then one or more lateral crural spanning sutures help in achieving supplementary eversion of the lateral crus. After establishing adequate projection, the tip rotation or position sutures are placed between the cranial edge of intermediate crura and the dorsal septum. The personal association of suture techniques is presented in this study and the long-term subjective and objective results are discussed along with the pros and cons

The challenging Silent sinus syndrome

The Silent sinus syndrome (SSS), first described in 1964 by Montgomery, is considered a relatively rare pathological entity, but it is presumably underdiagnosed and underreported. Terms such as imploding antrum and chronic maxillary atelectasis (CMA) have interchangeably been used to describe this syndrome, even though CMA has been postulated to represent either a different entity or a stage of evolution of the same disease. Bilateral involvement has been documented in a limited number of cases. Silent ethmoid sinus and silent frontal sinus syndromes have been described. The prevalent initial presentation is facial asymmetry with progressive “silent” painless unilateral enophthalmos and hypoglobus, and rarely diplopia. Isolated maxillary sinus hypoplasia must be differentiated. The etiopathogenesis is poorly understood and still under debate. According to the diagnostic criteria, SSS should spontaneously develops in absence of previous trauma or surgery. Secondary SSS to trauma or surgery, or to other causes like inflammation or tumor, has been documented in literature. The diagnosis relies on the CT, which typically shows unilateral hypoplastic and opacified maxillary sinus with inward bowing and remodeling of the sinus walls and inferior displacement of the orbital floor, an enlarged retroantral fat pad, a lateralized uncinate process, and a blocked ostiomeatal complex. The treatment of SSS aims at restoring the eye position and orbital floor height, to prevent progression of enophthalmos, to restore ventilation and drainage of the sinus. These objectives are achieved in single or two-stage surgery. The timing for management of the orbital floor is still under debate.The universally accepted treatment is surgical and usually accomplished by endoscopic sinus surgery. Associated middle turbinate hypertrophy and septal deviation must be previously addressed. Precise and gentle endoscopic removal of the obstruction of the ethmoid infundibulum, simply performing an inferior posteroanterior uncinectomy, since the uncinate process has constantly been found atelectatic and adherent to the lateral nasal wall, can reestablish the patency of the natural maxillary ostium. In our experience, following middle meatal antrostomy, long-term observation with staged orbital surgery, if required, is recommended. In this study, we present our cases with a focus on surgical stratagems developed in order to reduce the risk of injuring the orbit and to achieve long-lasting results

A proton-recoil track imaging system for fast neutrons: the RIPTIDE detector

Fast neutron detection is often based on the neutron-proton elastic scattering reaction: the ionization caused by recoil protons in a hydrogenous material constitutes the basic information for the design and development of a class of neutron detectors. Although experimental techniques have continuously improved, proton-recoil track imaging remains still at the frontier of n-detection systems, due to the high photon sensitivity required. Several state-of-the-art approaches for neutron tracking by using n-p single and double scattering - referred to as Recoil Proton Track Imaging (RPTI) - can be found in the literature. So far, they have showed limits in terms of detection efficiency, complexity, cost, and implementation. In order to address some of these deficiencies, we have proposed RIPTIDE a novel recoil-proton track imaging detector in which the light output produced by a fast scintillator is used to perform a complete reconstruction in space and time of the interaction events. The proposed idea is viable thanks to the dramatic advances in low noise and single photon counting achieved in the last decade by new scientific CMOS cameras as well as pixel sensors, like Timepix or MIMOSIS. In this contribution, we report the advances on the RIPTIDE concept: Geant4 Monte Carlo simulations, light collection tests as well as state-of-the-art approach to image readout, processing and fast analysis.Comment: proceeding of the 23rd International Workshop on Radiation Imaging Detectors, IWoRID 2022, 26-30 June 2022, Riva del Garda (TN), Ital

Neutrino masses and mixings in a seesaw framework

Assuming the seesaw mechanism for hierarchical neutrino masses, we calculate the heavy neutrino masses under the hypotheses that the mixing in the Dirac leptonic sector is similar to the quark mixing ($V_D \sim V_{CKM}$) and that $M_{\nu} \sim M_u$ or $M_e$, where $M_{\nu}$ is the Dirac mass matrix of neutrinos. As a result we find that for $M_{\nu} \sim M_u$ the vacuum oscillation solution of the solar neutrino problem leads to a scale for the heavy neutrino mass well above the unification scale, while for the MSW solutions there is agreement with this scale. For $M_{\nu} \sim M_e$ the vacuum solution is consistent with the unification scale, and the MSW solutions with an intermediate scale. The mass of the lightest heavy neutrino can be as small as $10^5$ GeV.Comment: 13 pages RevTex, no figures. Revised versio