Reply to ``Comment on `Majoron emitting neutrinoless double beta decay in the electroweak chiral gauge extensions' ''

We demonstrate that in the process of deducing the constraint on the electroweak mixing angle $\theta_{W}$ in our paper, we have indeed been working with three mass scales while implementing (331) model.Comment: Revtex, 3pages, Reply to hep-ph/9902448, Submitted to Phys. Rev.

Intensification of the freeze drying process by the control of both freezing and primary drying steps

The problem of optimization of freeze-drying cycles is addressed, with emphasis in both freezing and primary drying steps. In particular, this study shows that the control of the nucleation event produces more uniform batches (as ice nucleation is induced in all the vials of batch almost at the same time and temperature) and allows a marked reduction in the duration of the optimized cycle (if compared to cycles carried out with conventional stochastic nucleation

Continuous manufacturing of lyophilized products: Why and how to make it happen

This paper deals with the problem of continuous lyophilization of pharmaceutical products, focusing on those concepts that are of greatest interest and most likely to be successful once applied in industrial practice. Also, it discusses all those factors that slow down the transition from batch to continuous in the pharmaceutical industry, and what actions may accelerate this transformation

The ice-water interface and protein stability: a review

The ice-water interface is commonly encountered in our life, and comes into play in a wide number of natural phenomena. Here, attention will be focused on its effects on protein stability, with specific reference to the case of pharmaceutical proteins. This field represents a fascinating, and not yet fully understood, subject of investigation. Some background information on the ice-water phase diagram, as well as to the mechanisms of nucleation and crystal growth, will be provided. We will eventually discuss the effect of ice on protein activity, reviewing the mechanisms of ice-induced denaturation that have been proposed so far and discussing the strategies that may help prevent, or minimize, undesired loss of therapeutic activity

Dijet imbalance in hadronic collisions

The imbalance of dijets produced in hadronic collisions has been used to extract the average transverse momentum of partons inside the hadrons. In this paper we discuss new contributions to the dijet imbalance that could complicate or even hamper this extraction. They are due to polarization of initial state partons inside unpolarized hadrons that can arise in the presence of nonzero parton transverse momentum. Transversely polarized quarks and linearly polarized gluons produce specific azimuthal dependences of the two jets that in principle are not suppressed. Their effects cannot be isolated just by looking at the angular deviation from the back-to-back situation, rather they enter jet broadening observables. In this way they directly affect the extraction of the average transverse momentum of unpolarized partons that is thought to be extracted. We discuss appropriately weighted cross sections to isolate the additional contributions.Comment: 15 pages, 2 figures; revised version, published in Phys. Rev.

Removing beam asymmetry bias in precision CMB temperature and polarisation experiments

Asymmetric beams can create significant bias in estimates of the power spectra from CMB experiments. With the temperature power spectrum many orders of magnitude stronger than the B-mode power spectrum any systematic error that couples the two must be carefully controlled and/or removed. Here, we derive unbiased estimators for the CMB temperature and polarisation power spectra taking into account general beams and general scan strategies. A simple consequence of asymmetric beams is that, even with an ideal scan strategy where every sky pixel is seen at every orientation, there will be residual coupling from temperature power to B-mode power if the orientation of the beam asymmetry is not aligned with the orientation of the co-polarisation. We test our correction algorithm on simulations of two temperature-only experiments and demonstrate that it is unbiased. The simulated experiments use realistic scan strategies, noise levels and highly asymmetric beams. We also develop a map-making algorithm that is capable of removing beam asymmetry bias at the map level. We demonstrate its implementation using simulations and show that it is capable of accurately correcting both temperature and polarisation maps for all of the effects of beam asymmetry including the effects of temperature to polarisation leakage.Comment: 18 pages, 9 figure

Minimal extended flavor groups, matter fields chiral representations, and the flavor question

We show the specific unusual features on chiral gauge anomalies cancellation in the minimal, necessarily 3-3-1, and the largest 3-4-1 weak isospin chiral gauge semisimple group leptoquark-bilepton extensions of the 3-2-1 conventional standard model of nuclear and electromagnetic interactions. In such models a natural explanation for the fundamental question of fermion generation replication arises from the self-consistency of a local gauge quantum field theory, which constrains the number of the QFD fermion families to the QCD color charges.Comment: 10 pages. <[email protected]

Removing beam asymmetry bias in precision CMB temperature and polarisation experiments

Asymmetric beams can create significant bias in estimates of the power spectra from CMB experiments. With the temperature power spectrum many orders of magnitude stronger than the B-mode power spectrum any systematic error that couples the two must be carefully controlled and/or removed. Here, we derive unbiased estimators for the CMB temperature and polarisation power spectra taking into account general beams and general scan strategies. A simple consequence of asymmetric beams is that, even with an ideal scan strategy where every sky pixel is seen at every orientation, there will be residual coupling from temperature power to B-mode power if the orientation of the beam asymmetry is not aligned with the orientation of the co-polarisation. We test our correction algorithm on simulations of two temperature-only experiments and demonstrate that it is unbiased. The simulated experiments use realistic scan strategies, noise levels and highly asymmetric beams. We also develop a map-making algorithm that is capable of removing beam asymmetry bias at the map level. We demonstrate its implementation using simulations and show that it is capable of accurately correcting both temperature and polarisation maps for all of the effects of beam asymmetry including the effects of temperature to polarisation leakage.Comment: 18 pages, 9 figure