Data adaptive estimation of transversal blood flow velocities

The examination of blood flow inside the body may yield important information about vascular anomalies, such as possible indications of, for example, stenosis. Current medical ultrasound systems suffer from only allowing for measuring the blood flow velocity along the direction of irradiation, posing natural difficulties due to the complex behaviour of blood flow, and due to the natural orientation of most blood vessels. Recently, a transversal modulation scheme was introduced to induce also an oscillation along the transversal direction, thereby allowing for the measurement of also the transversal blood flow. In this paper, we propose a novel data-adaptive blood flow estimator exploiting this modulation scheme. Using realistic Field II simulations, the proposed estimator is shown to achieve a notable performance improvement as compared to current state-of-the-art techniques

Largest ancient fortress of South-West Asia and the western world?:Recent fieldwork at Sasanian Qaleh Iraj at Pishva, Iran

The article presents recent works at Qale Iraj, near Varamin, Iran. My short contribution is on the Middle Persian ostraka found at the site

P2-purinergic receptor agonists inhibit the growth of androgen-independent prostate carcinoma cells.

To develop a new approach to the treatment of advanced, hormone-refractory prostate cancer, the signal transductions regulating the growth of human androgen-independent prostate carcinoma cell lines were studied. Agonist-stimulated Ca2+ mobilization, a critical regulatory event in other secretory cell types, was studied as a means of identifying previously undescribed plasma membrane receptors that may transduce a growth inhibitory signal. In all of the cell lines tested, P2-purinergic receptor agonists, including ATP and certain hydrolysis-resistant adenine nucleotides, induced a rapid, transient increase in cytoplasmic free Ca2+ that was detectable at 50 to 100 nM ATP, was maximal at 100 microM ATP, and was inhibited approximately 50% by chelation of extracellular Ca2+. Within 8 s after addition, ATP stimulated accumulation of the polyphosphatidylinositol products inositol (1, 4, 5) trisphosphate, inositol (1, 3, 4) trisphosphate, and inositol tetrakisphosphate. In addition to stimulating phosphatidylinositol turnover and Ca2+ mobilization, ATP and hydrolysis-resistant ATP analogues induced greater than 90% inhibition of the growth of all lines tested. These data demonstrate that human androgen-independent prostate carcinoma cells express functional P2-purinergic receptors linked to phospholipase C, and that agonists of this receptor are markedly growth inhibitory, suggesting a novel therapeutic approach to this common adult neoplasm

The detergent Triton X-100 induces a death pattern in human carcinoma cell lines that resembles cytotoxic lymphocyte-induced apoptosis

AbstractThe detergent Triton X-100 (TX100) was used with the intention to establish a model for necrotic cell death. However TX100 was found to induce apoptotic and necrotic death in prostate and colon cancer cell lines. Apoptosis was characterized by the typical morphological features and internucleosomal DNA fragmentation. The rapid onset within 60 min and the lack of inhibition by cycloheximide indicated that apoptosis induced by TX100 was not dependent on protein synthesis. Removal of extracellular calcium blocked internucleosomal DNA fragmentation. This pattern of cell death shows a striking similarity to the effect of cytotoxic lymphocytes on their target cells

Contribution of climatic variability and human activities to stream flow changes in the Haraz River basin, northern Iran

Abstract In northern Iran’s Haraz River basin between 1975 and 2010, hydrological sensitivity, double mass curve, and Soil and Water Assessment Tool (SWAT) methods were applied to monitoring and analysing changes in stream flow brought on by climatic variability and human activities. Applied to analyse trends in annual and seasonal runoff over this period, the sequential MK test showed a sudden change point in stream flow in 1994. The study period was, therefore, divided into two sub-periods: 1975–1994 and 1995–2010. The SWAT model showed obvious changes in water resource components between the two periods: in comparison to the period of 1975–1994, sub-watershed-scale stream flow and soil moisture decreased during 1995–2010. Changes in evapotranspiration were negligible compared to those in stream flow and soil moisture. The hydrological sensitivity method indicated that climatic variability and human activities contributed to 29.86% and 70.14%, respectively, of changes in annual stream flow, while the SWAT model placed these contributions at 34.78% and 65.21%, respectively. The double mass curve method indicated the contribution of climatic variability to stream flow changes to be 57.5% for the wet season and 22.87% for the dry season, while human activities contributed 42.5% and 77.13%, respectively. Accordingly, in the face of climatic variability, measures should be developed and implemented to mitigate its impacts and maintain eco-environmental integrity and water supplies