9 research outputs found
Region of interest focused MRI to synthetic CT translation using regression and segmentation multi-task network
No full textIR-MALDESI Mass Spectrometry Imaging of Biological Tissue Sections Using Ice as a Matrix
No full textMixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle
No full textFunctions of the Hsp90-binding FKBP Immunophilins.
No full textHsp90 functionally interacts with a broad array of client proteins, but in every case examined Hsp90 is accompanied by one or more co-chaperones. One class of co-chaperone contains a tetratricopeptide repeat domain that targets the co-chaperone to the C-terminal region of Hsp90. Within this class are Hsp90-binding peptidylprolyl isomerases, most of which belong to the FK506-binding protein (FKBP) family. Despite the common association of FKBP co-chaperones with Hsp90, it is now clear that the client protein influences, and is influenced by, the particular FKBP bound to Hsp90. Examples include Xap2 in aryl hydrocarbon receptor complexes and FKBP52 in steroid receptor complexes. In this chapter, we discuss the known functional roles played by FKBP co-chaperones and, where possible, relate distinctive functions to structural differences between FKBP members
The order and priority of research and design method application within an assistive technology new product development process: a summative content analysis of 20 case studies
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