The effects of Anethum on plasma lipid and lipoprotein in normal and diabetic rats fed high fat diets

زمینه و هدف: هیپرلیپدمی از ریسک فاکتورهای اصلی در پیشرفت بیماری های قلبی عروقی می باشد. آنتوم داروی گیاهی است که به عنوان پایین آورنده چربی خون در ایران استفاده می شود. در این تحقیق اثرات هیپولیپیدمیک عصاره ترکیبی آنتوم (Anethum) در رت های سالم و دیابتی تغذیه شده با جیره غذایی پرچرب مورد بررسی قرار گرفت. روش بررسی: در این مطالعه تجربی تعداد 88 سر موش با تزریق استرپتوزوسین (STZ)دیابتی شدند. دو روز پس از دیابتی نمودن حیوانات، رت های سالم و دیابتی تحت تیمار با جیره غذایی پرچرب قرار گرفتند. یک هفته بعد از شروع جیره غذایی خاص، حیوانات به مدت سه هفته تحت تیمار دارویی با عصاره ترکیبی آنتوم (Anethum) قرار گرفتند. پس از این مدت خون گیری انجام شد و سطح گلوکز، تری گلیسرید تام، کلسترول تام و لیپوپروتئین های با چگالی بالا به روش آنزیمی اندازه گیری شد. مقدار لیپوپروتئین های با چگالی پایین با فرمول فریدولد محاسبه گردید. داده ها به کمک آزمون های آماری آنالیز واریانس یک راهه و توکی تجزیه و تحلیل شد. یافته ها: عصاره ترکیبی آنتوم در رت های سالم تغذیه شده با جیره غذایی پرچرب به صورت معنی داری سطـح تری گلیسرید تام و لیپوپروتئین های با چگالی پایین را کاهش (01/0

Investigating Knowledge Management Practices in a Successful Research and Development Organization

In this paper after a review on the concept and literature of knowledge management, the conceptual model of a successful knowledge management system that is currently being applied in a research and development (R&D) aerospace organization is presented and discussed. The main contribution of the paper is presenting the model in its useful and practical status without becoming involved in theoretical discussions that have different shapes but similar meanings

Elevating Women in the Workplace: The Dual Influence of Spiritual Intelligence and Ethical Environments on Job Satisfaction

In today's rapidly evolving workplace, the dynamics of job satisfaction and its determinants have become a focal point of organizational studies. This research offers a comprehensive examination of the nexus between spiritual intelligence and job satisfaction among female employees, with particular emphasis on the moderating role of ethical work environments. Beginning with an exploration of the multifaceted nature of human needs, the study delves deep into the psychological underpinnings that drive job satisfaction. It elucidates how various tangible and intangible motivators, such as salary benefits and recognition, play pivotal roles in shaping employee attitudes and behaviors. Moreover, the research spotlights the unique challenges and experiences of female employees, advocating for a more inclusive understanding of their needs. An extensive review of the literature and empirical analysis culminates in the pivotal finding that integrating spiritual intelligence and ethical considerations within organizational practices can significantly enhance job satisfaction. Such a holistic approach, the paper posits, not only bolsters the well-being and contentment of female employees but also augments overall organizational productivity, retention rates, and morale

Barriers to blockchain adoption in humanitarian logistics in an uncertain environment

In the digital age, blockchain technology is recognized as an operational innovation that is rapidly joining the field of supply chain and humanitarian logistics. Hence, blockchain technology has the potential to fundamentally change the field of humanitarian aid, but still relatively little research has been published aimed at improving understanding of the various barriers to blockchain adoption in humanitarian logistics. The aim of this research is to provide an integrated framework for evaluating the barriers to blockchain adoption in the field of humanitarian logistics. To assess the barriers, integrated approach has been applied in three phases. In the first phase of this approach, based on the literature, 10 barriers to the adoption of blockchain in humanitarian logistics are identified and evaluated using the FMEA method. In the second phase, using the opinions of experts, the weights of the three factors are calculated. Then, in the third phase and according to the outputs of the previous phases, obstacles are prioritized using the proposed Z-ARAS method. In addition to assigning different weights to the three factors considering uncertainty and reliability in barriers is also considered in this approach through the theory of Z numbers. The proposed approach of current study was implemented in the evaluation of blockchain adoption barriers in humanitarian logistics. According to the results, the most critical barriers concern with integrating issues, risk of cyber-attacks, and technology risks. The results shown the capability and superiority of the proposed approach compared to other traditional methods such as FMEA and Fuzzy ARAS

The effect of sulfoxo-bilactam-21-crown -7 on spermatogenesis in immature Balb/c mice

زمینه و هدف: کراون اترها ملکول های میزبان برای یون های فلزی و غیر فلزی هستند. توانایی کراون اترها در کنترل سیکل و تغییر فعالیت برخی از آنزیم ها گزارش شده است. در این مطالعه اثر یک کراون اتر جدید (سولفوکسو- بی لاکتام- 21- کراون-7) بر روی بافت بیضه و اسپرماتوژنز مورد بررسی قرار گرفته است. روش بررسی: در این مطالعه 24 سر موش نابالغ کوچک آزمایشگاهی (Balb/C) به سه گروه گروه کنترل (هیچ ماده ای دریافت نکردند)، شم )فقط توئین 80 دریافت کردند) و تجربی )سولفوکسو- بی لاکتام- 21- کراون-7 دریافت کردند) تقسیم شدند. Lethal dose 50 (LD50) دارو، به میزان 40 میلی گرم بر کیلوگرم تعیین شد. بر این اساس، دوز 20 میلی گرم بر کیلوگرم از این کراون اتر به روش درون صفاقی هر روز به مدت یک هفته به گروه تجربی تزریق شد. دو هفته پس از آخرین تزریق، حیوانات بیهوش شده و کشته شدند. خون جهت اندازه گیری هورمون از قلب گرفته شد. بافت بیضه، استخراج شد و جهت مطالعات بافت شناسی فیکس گردید. داده ها توسط آنالیز واریانس یکطرفه (ANOVA) و به دنبال آن تست توکی آنالیز شدند. یافته ها: تزریق درون صفاقی سولفوکسو- بی لاکتام- 21- کراون-7 (20 میلی گرم بر کیلوگرم) تغییر معنی داری در تعداد اسپرماتوگنی نوع A و B، اسپرماتوسیت اولیه و سلول های لیدیک در گروه تجربی در مقایسه با گروه کنترل و شم نشان نداد. افزایش هورمون جنسی مردانه، تستوسترون (001/0

The Effect of Medical Recording Training on Quantity and Quality of Recording in Gynecology Residents of Tabriz University of Medical Sciences

Introduction: Medical records contain valuable information about a patient's medical history and treatment. Patient safety is one of the most important dimensions of health care quality assurance and performance improvement. Completing the process of documentation is necessary to continue patient care and continuous quality improvement of basic services. The aim of the present study was to evaluate the effect of medical recording education on the quantity and quality of recording in gynecology residents of Tabriz University of Medical Sciences. Methods: This study is a quasi-experimental study and was conducted at Al-Zahra Teaching Hospital, Tabriz, Iran, in 2016. Thirty-two second through fourth year gynecologic residents of Tabriz University of Medical Sciences who were willing to participate in the study were included by census sampling and participated in training workshop. Three evaluators reviewed the residents’ records before and after training course by a checklist. Statistical analyses were performed using SPSS 13 software. P-values less than 0.05 were considered statistically significant. Results: The results showed that before the intervention, there were significant differences in the quantity of information status among the evaluators and no significant difference was observed in the recording of qualitative status. After the workshop, among the 3 evaluators, there were also significant differences in the quantity of data recording status; however, no significant change was observed in recording of qualitative status. Conclusion: The study findings revealed that a sectional training course of correct and standardized medical records has no effect on reforming the process of recording

Evaluation chain management model with emphasis on intellectual capital using blockchain technology

Purpose: The main purpose of this paper is the evaluation of the chain management model with an emphasis on intellectual capital in knowledge-based organizations using blockchain technology. Research methodology: First, by reviewing previous studies and researches, the framework for readiness to accept blockchain was extracted. Then, the different areas of the value chain of knowledge-based organizations were identified. Then, a questionnaire for pairwise comparisons was distributed using a hierarchical approach. Finally, the TOPSIS questionnaire was distributed to rank the 5 identified areas of activity in the value chain and knowledge management of knowledge-based organizations. Semi-structured interviews with the organization's experts have been used to explain the promising methods in the organization further to improve the efficiency of blockchain acceptance and meaningful research orientations for researchers. Results: These findings include the undiscovered potential of knowledge sharing and collaboration networks, the expected evolutionary stages of the Internet of Things, and eliminating intermediaries that lead to new business models such as token building and short-term rather than long-term relationships. Obstacles include staffing problems, legal uncertainty, loss of infrastructure and standardization, and unclear governance structures. Improving smart contract security and interoperability between private and public protocols will further expand technolog Contribution: The application of blockchain technology in the field of knowledge and intellectual capital management, due to the promotion of key indicators such as improving security in the context of non-forgery, unchangeable information, tracking, decentralization, and transparency, leads to the application of this technology in knowledge and intellectual capital management

Influence of intracerebral administration of L-NAME in dorsal hippocampus (CA1) on WIN55, 212-2 induced state-dependent memory in the step-down passive avoidance test

(Received 28 February, 2009 ; Accepted 8 July, 2009)AbstractBackground and purpose: This study presents the effects of nitricoxide synthase inhibitor (L-NAME) on WIN55, 212-2 induced state-dependent memory of passive avoidance task, which were examined in mice. Materials and methods: Mice were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine and then placed in a stereotaxic apparatus. Also, two stainless-steel annuals were placed 1 min above CA1. One-trial step-down paradigm was used for the assessment of memory retention in adult male NMRI mice.Results: Post-training intra-CA1 administration of WIN55, 212-2 (0.5 and 1 µg/mouse), dose-dependent decreased the memory retrieval. The memory impairment induced by post-training administration of WIN55, 212-2 (1µg/mouse), was restored by pre-test administration with the same dose of drug (1μg/mouse, intra-CA1). Single intra-CA1 administration of L-NAME (0.3, 1 and 3 µg/mouse), 5 minute pre-test could not alter memory retrieval. Also, in animals in which retrieval was impaired due to post-training administration of WIN55, 212-2 (1µg/mouse), pre-test intra-CA1 administration of L-NAME (0.3, 1 and 3 µg/mouse) 24 hours after training, could not restore memory retrieval. Furthermore, in animals which received both post-training (1µg/mouse) and pre-test injection of WIN55, 212-2 (1µg/mouse), the injection of L-NAME (3 µg/mouse, intra-CA1), 2 minute before pre-test administration decreased retrieval.Conclusion: These findings may demonstrate the involvement of NO in state-dependent memory induced by intra-CA1 administration of WIN55, 212-2.J Mazand Univ Med Sci 2009; 19(71): 1-9 (Persian