Transferência de nutrientes por vias hidrológicas em três pequenas bacias sob uso agrícola familiar no nordeste paraense: chuva, escoamento superficial em solos e águas fluviais.

Poster 651. Disponível também on-line

Zoom-in-Net: Deep Mining Lesions for Diabetic Retinopathy Detection

We propose a convolution neural network based algorithm for simultaneously diagnosing diabetic retinopathy and highlighting suspicious regions. Our contributions are two folds: 1) a network termed Zoom-in-Net which mimics the zoom-in process of a clinician to examine the retinal images. Trained with only image-level supervisions, Zoomin-Net can generate attention maps which highlight suspicious regions, and predicts the disease level accurately based on both the whole image and its high resolution suspicious patches. 2) Only four bounding boxes generated from the automatically learned attention maps are enough to cover 80% of the lesions labeled by an experienced ophthalmologist, which shows good localization ability of the attention maps. By clustering features at high response locations on the attention maps, we discover meaningful clusters which contain potential lesions in diabetic retinopathy. Experiments show that our algorithm outperform the state-of-the-art methods on two datasets, EyePACS and Messidor.Comment: accepted by MICCAI 201

La consolidación de las fracturas diafisarias del radio en el adulto : resultados del tratamiento con osteosíntesis por autocompresión

Los autores presentan un análisis de la consolidación de las fracturas de diáfisis del radio tratadas mediant e osteosíntesis de autocompresión tipo "Bagby", en 30 pacientes atendidos en el Departamento de Ortopedia y Traumatología del "Hospital das Clínicas" de la F.M.U.S.P., en el período de 1975 a 1985. 24 (80%) paciente s eran hombre s y 6 (20%) mujeres, con edade s comprendidas entr e 18 y 47 años (edad media 30.1 años). Se utilizaron placas "Bagby" de 4 y 6 agujeros (4 en 18 casos y 6 en 12 casos). Los resultados fueron buenos en 24 casos, regulares en 4 y malos en 2 casos. No se produjeron pseudoartrosis, sin embargo, si se observaron 2 retardos de consolidación. El tiempo medio de consolidación fue de 9 semanas (rango 6-16 semanas). No hubieron infecciones. En un pacient e hubo dehiscencia de sutura, en otro una reacción alérgica al metal y en dos paciente s se produjo un paresia del nervio radial con recuperación espontánea . En tre s casos, despué s de la retirada de la placa hubo espongialización subyacente. No hubo refracturas en esta serie.The author s carried out an analysis of healing in shaft fractures of radius treated by compression bone plating (Bagby System). 30 patients treated in the Department of Orthopaedi c Surgery of "Hospital das Clínicas" (F.M.U.S.P.) betwee n 1975 and 1985 wer e includedin this study. 24 (80%) of patients wer e men and 6 (20%) women; average of age was 30.1 year s (rangel8-47). Bagby plate s with 4 and 6 screws (18 and 6 case s respectively) wer e used by the authors. Good results wer e obtained in 24 patients, fair in 4 cases of delayed union wer e observed. The average of healing was 9 week s (6-16). One patient showed dehiscenc e of the wound, and othe r allergic reaction to metal. Two patients had paresia of radial nerve resolved spontaneously. In three cases, showed local osteoporosis after the plat e wa s removed. No case s of refractur e wer e observed in this series

Arabic version of the Personality Inventory for the DSM-5 (PID-5) in a community sample of United Arab Emirates nationals

Background: Section III of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) proposes a model for conceptualizing personality disorders in which they are characterized by impairments in personality functioning and maladaptive personality traits. The Personality Inventory for DSM-5 (PID-5) is a self-report measure that assesses the presence and severity of these maladaptive personality traits. Objective: The current study examined the reliability and validity of the Arabic version of the Personality Inventory for DSM-5 (PID-5) to measure maladaptive personality traits in the Emirati population of the United Arab Emirates. Methods: The Arabic version of the PID-5 was administered to a community sample of 1,090 United Arab Emirates nationals (89.5% female and 10.5% male, mean age = 22.44 years old). The descriptive measures, internal consistency, test-retest reliability, convergent validity with NEO – Five Factor Inventory, as well as PID-5’s factor structure, were all addressed. Results: The PID-5facets and domains mean scores were higher in the Emirati sample compared to the original US sample. Internal consistency of the PID-5 scales was acceptable to high and test-retest coefficients ranged from 0.84 (facets) to 0.87 (domains). As expected, the five domains of the Arabic version of the PID-5 correlated significantly with all Five-Factor Model domains of personality. Additionally, the Arabic version of the PID-5 confirmed a five-factor structure that resembles the PID-5 domains. Conclusion: The findings of this study provided initial support for the use of the Arabic version of the PID-5 to assess maladaptive personality traits in the Emirati population of the United Arab Emirates.info:eu-repo/semantics/publishedVersio

Avaliação fenológica da espécie Coronopus didymus (L.) Smith.

Entre as plantas que possuem efeito medicinal comprovado na flora Amazônica temos Coronopus didymus, conhecida popularmente como mastrunço ou mastruz, pertencente à família Brassicaceae (Cruciferae). Um dos passos iniciais mais importantes para o conhecimento e utilização das espécies vegetais é o estudo da sua biologia, em particular o da fenologia. Objetivou-se com o presente trabalho avaliar as características fenológicas, período de floração e frutificação da espécie C. didymus cultivada na coleção do horto de plantas medicinais da Embrapa Amazônia Oriental. Diariamente foram coletados no período de janeiro de 2010 a dezembro de 2013, dados de floração e frutificação e registrados em fichas de campo e tabulados em planilhas do Excel. Posteriormente, foram construídos gráficos para a espécie em cada fenofase. Ocorreu floração durante todos os meses do ano, exceto nos meses de junho, julho e dezembro, sendo registrada nos meses de março, maio e outubro a maior e menor média para floração, respectivamente, 7 e 2 dias. A frutificação ocorreu somente nos meses de fevereiro, março, maio e junho sendo registrada as maiores médias nos meses de março e maio com 7 dias, e a menor com 5 dias para o mês de fevereiro. A espécie C. didymus apresenta um período de floração e frutificação, respectivamente, de 9 e 4 meses

New synthetic raloxifen-like di(hetero)arylamines induce apoptosis and inhibit the estrogen receptor in breast cancer cells

Breast cancer is the most common form of cancer in women in the western world, and in spite of some decline in death rates in recent years it is still the second most common cause of death from cancer, in women (1). For more than three decades, the estrogen receptor (ER) has been the most important biomarker of breast cancer, largely due to the substantial benefit that endocrine therapy provides in the treatment of ER positive tumors, in women of all ages (2). Endocrine therapies currently available include selective estrogen receptor modulators (SERMs), like tamoxifen and raloxifene (3). Raloxifene acts as an estrogen antagonist in the breast by competitive binding to the ER, inhibiting estrogen-induced breast tissue proliferation and preventing the growth of mammary tumors. In addition, it shows no increase in incidence of endometrial cancer, which is an advantage compared to tamoxifen (4). The successes of these endocrine therapies, however, are often limited. So, it is important to continue searching for new strategies and/or drugs that overcome resistance problems and that can be potent enough with fewer adverse effects. In this work, we studied the effect of two new synthetic di(hetero)arylamines, named MJQ2 and MJQ3 (which have in common with raloxifene a benzothiophene ring), in cell proliferation and apoptosis of two different cell lines from breast cancer: MCF-7 (ER positive) and MDA-MB-231 (ER negative). Our results showed that both diarylamines induce apoptosis without significant necrosis (evaluated by Hoechst-PI staining), at the IC50 concentration that inhibits cell proliferation (evaluated by the SRB assay). The results obtained with TMRM, a marker of mitochondrial membrane potential, suggest that mitochondrial disruption can be involved in this apoptotic process. These effects are more pronounced in the MCF-7 cell line (ER positive), suggesting that the presence of the ER might be important in the response to these compounds. Confirmation of their interaction with the ER was obtained in the E-Screen assay, where a clear antagonism of the proliferative effects of the hormone 17β-estradiol was observed with both compounds, at non-toxic concentrations. The overall results suggest that these new synthetic “raloxifene-like” drugs might have potential to be further developed as alternative hormonal or adjuvant therapies for breast cancer.Fundação para a Ciência e a Tecnologia (FCT) research project PTDC/QUI/68382/2006 (FCOMP-01-0124-FEDER 007441)