Temporal Relational Reasoning in Videos

Temporal relational reasoning, the ability to link meaningful transformations of objects or entities over time, is a fundamental property of intelligent species. In this paper, we introduce an effective and interpretable network module, the Temporal Relation Network (TRN), designed to learn and reason about temporal dependencies between video frames at multiple time scales. We evaluate TRN-equipped networks on activity recognition tasks using three recent video datasets - Something-Something, Jester, and Charades - which fundamentally depend on temporal relational reasoning. Our results demonstrate that the proposed TRN gives convolutional neural networks a remarkable capacity to discover temporal relations in videos. Through only sparsely sampled video frames, TRN-equipped networks can accurately predict human-object interactions in the Something-Something dataset and identify various human gestures on the Jester dataset with very competitive performance. TRN-equipped networks also outperform two-stream networks and 3D convolution networks in recognizing daily activities in the Charades dataset. Further analyses show that the models learn intuitive and interpretable visual common sense knowledge in videos.Comment: camera-ready version for ECCV'1

KRAS early testing. Consensus initiative and cost-effectiveness evaluation for metastatic colorectal patients in an italian setting

KRAS testing is relevant for the choice of the most appropriate first-line therapy of metastatic colorectal cancer (CRC). Strategies for preventing unequal access to the test should be implemented, but their relevance in the practice is related to economic sustainability. The study adopted the Delphi technique to reach a consensus on several topics. Issues related to execution of KRAS testing were identified by an expert's board and proposed to 108 Italian oncologists and pathologists through two subsequent questionnaires. The emerging proposal was evaluated by decision analyses models employed by technology assessment agencies in order to assess cost-effectiveness. Alternative therapeutic strategies included most commonly used chemotherapy regimens alone or in combination with cetuximab or bevacizumab. The survey indicated that time interval for obtaining KRAS test should not exceed 15 days, 10 days being an optimal interval. To assure the access to proper treatment, a useful strategy should be to anticipate the test after radical resection in patients at high risk of relapse. Early KRAS testing in high risk CRC patients generates incremental cost-effectiveness ratios between 6,000 and 13,000 Euro per quality adjusted life year (QALY) gained. In extensive sensitivity analyses ICER's were always below 15,000 Euro per QALY gained, far within the threshold of 60,000 Euro/QALY gained accepted by regulatory institutions in Italy. In metastatic CRC a time interval higher than 15 days for result of KRAS testing limits access to therapeutic choices. Anticipating KRAS testing before the onset of metastatic disease in patients at high risk does not affect the sustainability and cost-effectiveness profile of cetuximab in first-line mCRC. Early KRAS testing may prevent this inequality in high-risk patients, whether they develop metastases, and is a cost-effective strategy. Based on these results, present joined recommendations of Italian societies of Oncology and Pathology should be updated including early KRAS testing

No room at the top? A system dynamics view of the recursive consequences of women’s underrepresentation in international assignments

Purpose: The expatriation literature has developed an insightful body of research on the reasons why women are not assigned abroad as frequently as men. However, we know very little about the systemic and recursive consequences of women’s underrepresentation in international assignments (IAs), which are examined in this conceptual paper. Design/methodology/approach: Drawing upon expatriation research and a system dynamics perspective, we propose a conceptual model to explain both women’s underrepresentation in IAs and its recursive consequences. Findings: We highlight how women’s underrepresentation in IAs results from a complex system of recursive effects that jeopardizes women’s professional development and undermines both their own career progression to top management and firms’ competitive advantage and international growth. We argue that organizations make decisions that contravene their own interest in a competitive global environment. First, because they are limiting their talent pool by not considering female candidates. Second, because they are missing the opportunity to use IAs to advance women’s careers. Research implications/limitations: Our model provides a solid grounding for future research on selecting the most effective organizational actions and designing support-ive measures to disrupt the persistent dynamics contributing to women’s underrepresentation in IAs. Future research could also expand our study by incorporating individual differences and the proactive role that women may take. Managerial implications: Our model points to specific managerial interventions (e.g., increased access to job-training and specific training ahead of the assignment, dual-career support, women’s mentoring, and affirmative action) which have the potential to reduce women’s underrepresentation in IAs and in top management. Originality: Our system dynamics approach enables a broader understanding of why women are underrepresented in IAs, how this underrepresentation further exacer-bates gender segregation in international business, and how these recursive outcomes can be averted to the advantage of firms’ sustainable growth

The SUMMIT trial: a field comparison of buprenorphine versus methadone maintenance treatment.

This prospective patient-preference study examined the effectiveness in practice of methadone versus buprenorphine maintenance treatment and the beliefs of subjects regarding these drugs. A total of 361 opiate-dependent individuals (89% of those eligible, presenting for treatment over 2 years at a drug service in England) received rapid titration then flexible dosing with methadone or buprenorphine; 227 patients chose methadone (63%) and 134 buprenorphine (37%). Participants choosing methadone had more severe substance abuse and psychiatric and physical problems but were more likely to remain in treatment. Survival analysis indicated those prescribed methadone were over twice as likely to be retained (hazard ratio for retention was 2.08 and 95% confidence interval [CI] = 1.49-2.94 for methadone vs. buprenorphine), However, those retained on buprenorphine were more likely to suppress illicit opiate use (odds ratio = 2.136, 95% CI = 1.509-3.027, p < .001) and achieve detoxification. Buprenorphine may also recruit more individuals to treatment because 28% of those choosing buprenorphine (10% of the total sample) stated they would not have accessed treatment with methadone

Selection Effects, Biases, and Constraints in the Calan/Tololo Supernova Survey

We use Monte Carlo simulations of the Calan/Tololo photographic supernova survey to show that a simple model of the survey's selection effects accounts for the observed distributions of recession velocity, apparent magnitude, angular offset, and projected radial distance between the supernova and the host galaxy nucleus for this sample of Type Ia supernovae (SNe Ia). The model includes biases due to the flux-limited nature of the survey, the different light curve morphologies displayed by different SNe Ia, and the difficulty of finding events projected near the central regions of the host galaxies. From these simulations we estimate the bias in the zero-point and slope of the absolute magnitude-decline rate relation used in SNe Ia distance measurements. For an assumed intrinsic scatter of 0.15 mag about this relation, these selection effects decrease the zero-point by 0.04 mag. The slope of the relation is not significantly biased. We conclude that despite selection effects in the survey, the shape and zero-point of the relation determined from the Calan/Tololo sample are quite reliable. We estimate the degree of incompleteness of the survey as a function of decline rate and estimate a corrected luminosity function for SNe Ia in which the frequency of SNe appears to increase with decline rate (the fainter SNe are more common). Finally, we compute the integrated detection efficiency of the survey in order to infer the rate of SNe Ia from the 31 events found. For a value of Ho=65 km/sec/Mpc we obtain a SN Ia rate of 0.21(+0.30)(-0.13) SNu. This is in good agreement with the value 0.16+/-0.05 SNu recently determined by Capellaro et al. (1997).Comment: 36 pages, 19 figures as extra files, to appear in the A

The motion of two masses coupled to a massive spring

We discuss the classical motion of a spring of arbitrary mass coupled to two arbitrary massive blocks attached at its ends. A general approach to the problem is presented and some general results are obtained. Examples for which a simple elastic function can be inferred are discussed and the normal modes and normal frequencies obtained. An approximation procedure to the evaluation of the normel frequencies in the case of uniform elastic function and mass density is also discussed.Comment: Standard Latex file plus three eps figure