3 research outputs found
Digital transformation : construct definition challenges and scenarios for a research agenda
Indeed, digital transformation is just like the new models of the various technological devices (smartphones, tablets, smart watches) that are used without us fully mastering their resources. It is happening in an accelerated way without even having a clear understanding of the phenomenon. It is typically a situation in which reality occurs at a speed greater than its understanding, thus claiming the researchers' positioning in the face of digital contemporaneity. Just like Uber, that initially imposed itself as a “de facto” reality (in practice) before becoming a de jure standard (supported by law), the research agenda digital transformation seeks to guide the future of research in the field, but, due to the speed of changes, it may fit into the metaphor of the lantern on the ship's stern, helping to illuminate the past. Even though the organizational practice is more agile than the academy, it is still worth emphasizing the fundamental role of research in interpreting the nuances of the phenomenon through the most diverse perspectives..info:eu-repo/semantics/publishedVersio
Abiraterone plus prednisone in metastatic, castration-sensitive prostate cancer
BACKGROUND:
Abiraterone acetate, a drug that blocks endogenous androgen synthesis, plus prednisone is indicated for metastatic castration-resistant prostate cancer. We evaluated the clinical benefit of abiraterone acetate plus prednisone with androgen-deprivation therapy in patients with newly diagnosed, metastatic, castration-sensitive prostate cancer.
METHODS:
In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 1199 patients to receive either androgen-deprivation therapy plus abiraterone acetate (1000 mg daily, given once daily as four 250-mg tablets) plus prednisone (5 mg daily) (the abiraterone group) or androgen-deprivation therapy plus dual placebos (the placebo group). The two primary end points were overall survival and radiographic progression-free survival.
RESULTS:
After a median follow-up of 30.4 months at a planned interim analysis (after 406 patients had died), the median overall survival was significantly longer in the abiraterone group than in the placebo group (not reached vs. 34.7 months) (hazard ratio for death, 0.62; 95% confidence interval [CI], 0.51 to 0.76; P<0.001). The median length of radiographic progression-free survival was 33.0 months in the abiraterone group and 14.8 months in the placebo group (hazard ratio for disease progression or death, 0.47; 95% CI, 0.39 to 0.55; P<0.001). Significantly better outcomes in all secondary end points were observed in the abiraterone group, including the time until pain progression, next subsequent therapy for prostate cancer, initiation of chemotherapy, and prostate-specific antigen progression (P<0.001 for all comparisons), along with next symptomatic skeletal events (P=0.009). These findings led to the unanimous recommendation by the independent data and safety monitoring committee that the trial be unblinded and crossover be allowed for patients in the placebo group to receive abiraterone. Rates of grade 3 hypertension and hypokalemia were higher in the abiraterone group.
CONCLUSIONS:
The addition of abiraterone acetate and prednisone to androgen-deprivation therapy significantly increased overall survival and radiographic progression-free survival in men with newly diagnosed, metastatic, castration-sensitive prostate cancer. (Funded by Janssen Research and Development; LATITUDE ClinicalTrials.gov number, NCT01715285 .)