Intracranial atherosclerotic disease associated with moyamoya collateral formation: histopathological findings

Atherosclerotic disease has been suspected as a cause of moyamoya disease in some patients but has not, to the authors’ knowledge, been confirmed by pathological studies. The authors present the histopathological findings in a patient with moyamoya collateral formation associated with atherosclerotic occlusive disease of the distal internal carotid artery (ICA). Typical atheromatous changes were evident in the distal ICA and proximal middle cerebral artery. In addition, intimal thickening, fibrosis, and abnormal internal elastic lamina were present in these vessels. These findings are common in moyamoya but not in atherosclerotic disease. Proliferation and enlargement of the lenticulostriate arteries in the basal ganglia was also identified. Moyamoya phenomenon secondary to atherosclerotic disease has similar histopathological features to idiopathic moyamoya phenomenon, both in the affected large basal arteries and lenticulostriate collaterals. These findings support the hypothesis advanced by Peerless that moyamoya is a 2-step process involving an obliterative vasculopathy of the terminal ICA and a secondary proliferative response

Alpha to Omega: A Neurological Analysis of Marital Conflict in a Pilot Study

Although the linkage between health and marriage has been noted (e.g., Hayward and Gorman in Demography 41:87-107. doi:10.1353/dem.2004.0005, 2004; Kaplan and Kronick in J Epidemiol Community Health 60:760-765. doi:10.1136/jech.2005.037606, 2006; Schoenborn in Marital status and health: United States, 1999-2002. Advance data from vital and health statistics. National Center for Health Statistics, Hyattsville, MD, 2004), understanding the connection between neurological and behavioral phenomena in marital relationships has yet to be tackled. This pilot study attempted to address this limitation by analyzing electrical brain activity during a conflict interaction between married couples. Results generally supported the work of Lazarus (Emotion and adaptation. Oxford University Press, Oxford, 1991) and Harmon-Jones et al. (J Pers Soc Psychol 82:610-618. doi:10.1037//0022-3514.82.4.610, 2002); individuals that felt like they were in an action-possible situation revealed relatively higher left hemispheric activity in the frontal region of the brain. © 2014 Springer Science+Business Media New York

Coupling between resting cerebral perfusion and EEG

While several studies have investigated interactions between the electroencephalography (EEG) and functional magnetic resonance imaging BOLD signal fluctuations, less is known about the associations between EEG oscillations and baseline brain haemodynamics, and few studies have examined the link between EEG power outside the alpha band and baseline perfusion. Here we compare whole-brain arterial spin labelling perfusion MRI and EEG in a group of healthy adults (n = 16, ten females, median age: 27 years, range 21-48) during an eyes closed rest condition. Correlations emerged between perfusion and global average EEG power in low (delta: 2-4 Hz and theta: 4-7 Hz), middle (alpha: 8-13 Hz), and high (beta: 13-30 Hz and gamma: 30-45 Hz) frequency bands in both cortical and sub-cortical regions. The correlations were predominately positive in middle and high-frequency bands, and negative in delta. In addition, central alpha frequency positively correlated with perfusion in a network of brain regions associated with the modulation of attention and preparedness for external input, and central theta frequency correlated negatively with a widespread network of cortical regions. These results indicate that the coupling between average EEG power/frequency and local cerebral blood flow varies in a frequency specific manner. Our results are consistent with longstanding concepts that decreasing EEG frequencies which in general map onto decreasing levels of activation