VLBI study of water maser emission in the Seyfert 2 galaxy NGC5793. I: Imaging blueshifted emission and the parsec-scale jet

We present the first result of VLBI observations of the blueshifted water maser emission from the type 2 Seyfert galaxy NGC5793, which we combine with new and previous VLBI observations of continuum emission at 1.7, 5.0, 8.4, 15, and 22 GHz. Maser emission was detected earlier in single-dish observations and found to have both red- and blueshifted features relative to the systemic velocity. We could image only the blueshifted emission, which is located 3.6 pc southwest of the 22 GHz continuum peak. The blueshifted emission was found to originate in two clusters that are separated by 0.7 milliarcsecond (0.16 pc). No compact continuum emission was found within 3.6 pc of the maser spot. A compact continuum source showing a marginally inverted spectrum between 1.7 and 5.0 GHz was found 4.2 pc southwest of the maser position. The spectral turnover might be due to synchrotron self-absorption caused by a shock in the jet owing to collision with dense gas, or it might be due to free-free absorption in an ionized screen possibly the inner part of a disk, foreground to the jet. The water maser may be part of a maser disk. If so, it would be rotating in the opposite sense to the highly inclined galactic disk observed in CO emission. We estimate a binding mass within 1 pc of the presumed nucleus to be on the order of 10^7 Msun. Alternatively, the maser emission could result from the amplification of a radio jet by foreground circumnuclear molecular gas. In this case, the high blueshift of the maser emission might mean that the masing region is moving outward away from the molecular gas surrounding an active nucleus.Comment: 20 pages, 6 figures, to appear in ApJ, Oct. 200

Chasing the Galactic structure using VLBI and Gaia

Galaxie

Very Large Array Observations of Galactic Center OH 1720 MHz Masers in Sagittarius A East and in the Circumnuclear Disk

We present Very Large Array (VLA) radio interferometry observations of the 1720 MHz OH masers in the Galactic Center (GC). Most 1720 MHz OH masers arise in regions where the supernova remnant Sgr A East is interacting with the interstellar medium. The majority of the newly found 1720 MHz OH masers are located to the northeast, independently indicating and confirming an area of shock interaction with the +50 km/s molecular cloud (M-0.02-0.07) on the far side of Sgr A East. The previously known bright masers in the southeast are suggested to be the result of the interaction between two supernova remnants, instead of between Sgr A East and the surrounding molecular clouds as generally found elsewhere in the Galaxy. Together with masers north of the circumnuclear disk (CND) they outline an interaction on the near side of Sgr A East. In contrast to the interaction between the +50 km/s cloud and Sgr A East, OH absorption data do not support a direct interaction between the CND material and Sgr A East. We also present three new high-negative velocity masers, supporting a previous single detection. The location and velocities of the high-negative and high-positive velocity masers are consistent with being near the tangent points of, and physically located in the CND. We argue that the high velocity masers in the CND are pumped by dissipation between density clumps in the CND instead of a shock generated by the supernova remnant. That is, the CND masers are not coupled to the supernova remnant and are sustained independently.Comment: accepted to ApJ, 9 pages 3 figure

HI Absorption in the Gigamaser Galaxy TXS 2226-184 and the Relation between HI Absorption and Water Emission

We report on the discovery of HI in absorption toward the gigamaser galaxy TXS2226-184 using the VLA. The absorption appears to consist of two components -- one with a width of 125 km/s, and one broader (420 km/s), both toward the compact radio source in the nucleus of the galaxy. Based on these large velocity widths we suggest that the HI absorption is produced in the central parsecs of the galaxy, on a similar scale to that which gives rise to the water maser emission. This brings to eight the number of galaxies known to exhibit both water masers and HI absorption. We explore the relationship between these two phenomena, and present a physically motivated (but unfruitful) search for water maser emission in five radio galaxies known to exhibit strong HI absorption.Comment: 19 pages including 5 figures, LaTeX, Accepted to Ap

Oral Health Status of Patients with Mental Disorders in Southwest Ethiopia

BACKGROUND: Psychiatric disorders are known to be a risk factor for the development of different oral health problems especially for dental caries and periodontal diseases. In spite of this fact, no study has been conducted to reveal its magnitude in Ethiopia. Hence, this study was conducted to determine the oral health status of psychiatric patients at Jimma University Specialized Hospital (JUSH), Psychiatric Clinic. METHODS: A hospital based cross- sectional study was used from January to May 2011. A total of 240 participants were included in the study. Dental examination was done to measure indices of oral health: decayed, missing, and filled teeth (DMFT) index and community periodontal index (CPI). Oral examination was performed using mirror, probe and explorer by experienced dental doctors. A simple random sampling technique was implemented to collect data. ANOVA test, binary logistic and multinomial logistic regression analyses were done using SPSS 16.0 statistical software. RESULTS: The mean DMFT score among the psychiatric patients was 1.94 ± 2.12 (mean ± SD) with 1.28 ± 1.69, 0.51 ± 1.19 and 0.14 ± 0.48 (mean ± SD) for decayed, missed and filled teeth respectively. Only about 24% of the psychiatric patients had a healthy CPI score. Incorrect tooth brushing technique was significantly associated with a DMFT score greater than 2 (AOR = 3.58; 95% CI: 1.65, 7.79). The habit of sweet intake was also associated with dental caries (AOR = 2.91; 95% CI: 1.43, 5.95). Similarly, patients with a smoking habit also demonstrated statistically significant association with dental caries (AOR = 18.98; 95% CI: 5.06, 71.24). CONCLUSION: The oral health status of the psychiatric patients was poor. Thus, health education about oral hygiene should be given for psychiatric patients so they can avoid the frequent intake of sweets, smoking and learn correct tooth brushing technique

Relationship between soy and isoflavone intake and periodontal disease: The Freshmen in Dietetic Courses Study II

<p>Abstract</p> <p>Background</p> <p>Much research has shown that soy products inhibited various diseases. However, no published studies have examined the effects of consumption of soy and isoflavones on periodontal disease. The aim of this study was to investigate whether soy and isoflavone intake is associated with the prevalence of periodontal disease.</p> <p>Methods</p> <p>The subjects were 3956 Japanese female students, aged 18 to 22 years, who were taking a dietetic course. Periodontal disease was defined as present when a subject reported diagnosis of the disorder by a dentist. Information on dietary factors was collected using a validated diet history questionnaire. Logistic regression analysis was used to estimate the odds ratios and their confidence intervals of periodontal disease. Adjustment was made for cigarette smoking, toothbrushing frequency, region of residence, and body mass index.</p> <p>Results</p> <p>The prevalence of periodontal disease was 8.0%. Intake of total soy product and tofu was independently associated with a decreased prevalence of periodontal disease; multivariate odds ratios in comparison of the highest with the lowest quintile were 0.68 and 0.68, respectively (95% confidence intervals = 0.47–0.97 and 0.47–0.98, <it>P </it>for trend = 0.01 and 0.004, respectively). A significant inverse dose-response relationship between the intake of isoflavones and the prevalence of periodontal disease was observed, although the difference in the adjusted odds ratio between the extreme quintiles was of borderline significance (<it>P </it>for trend = 0.04). There were no measurable dose-response relationships between consumption of tofu products, fermented soybeans, boiled soybeans, miso, or miso soup and the prevalence of periodontal disease.</p> <p>Conclusion</p> <p>Our findings suggest that soy and isoflavone intake may decrease the likelihood of periodontal disease. Further investigations with objective measures for periodontal disease are needed to confirm our findings.</p

Epigenetic change in e-cardherin and COX-2 to predict chronic periodontitis

<p>Abstract</p> <p>Background</p> <p>DNA methylation of certain genes frequently occurs in neoplastic cells. Although the cause remains unknown, many genes have been identified with such atypical methylation in neoplastic cells. The hypermethylation of E-Cadherin and Cyclooxygenase 2 (COX-2) in chronic inflammation such as chronic periodontitis may demonstrate mild lesion/mutation epigenetic level. This study compares the hypermethylation status of E-Cadherin and COX-2 genes which are often found in breast cancer patients with that in chronic periodontitis.</p> <p>Methods</p> <p>Total DNA was extracted from the blood samples of 108 systemically healthy non-periodontitis subjects, and the gingival tissues and blood samples of 110 chronic periodontitis patient as well as neoplastic tissues of 106 breast cancer patients. Methylation-specific PCR for E-Cadherin and COX-2 was performed on these samples and the PCR products were analyzed on 2% agarose gel.</p> <p>Results</p> <p>Hypermethylation of E-Cadherin and COX-2 was observed in 38% and 35% of the breast cancer samples, respectively. In chronic periodontitis patients the detection rate was 25% and 19% respectively, and none was found in the systemically healthy non-periodontitis control subjects. The hypermethylation status was shown to be correlated among the three groups with statistical significance (p < 0.0001). The methylation of CpG islands in E-Cadherin and COX-2 genes in periodontitis patients occurs more frequently in periodontitis patients than in the control subjects, but occurs less frequently than in the breast cancer patients.</p> <p>Conclusions</p> <p>This set of data shows that the epigenetic change in E-Cadherin and Cyclooxygenase-2 is associated with chronic periodontitis. The epigenetic changes presented in chronic inflammation patients might demonstrate an irreversible destruction in the tissues or organs similar to the effects of cancer. Chronic periodontitis to some extent might be associated with DNA hypermethylation which is related to cancer risk factors.</p

Acquisition of Complement Inhibitor Serine Protease Factor I and Its Cofactors C4b-Binding Protein and Factor H by Prevotella intermedia

Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis. The serine protease Factor I (FI) is the central inhibitor of complement degrading complement components C3b and C4b in the presence of cofactors such as C4b-binding protein (C4BP) and Factor H (FH). Yet, the significance of complement inhibitor acquisition in P. intermedia infection and FI binding by Gram-negative pathogens has not been addressed. Here we show that P. intermedia isolates bound purified FI as well as FI directly from heat-inactivated human serum. FI bound to bacteria retained its serine protease activity as shown in degradation experiments with 125I-labeled C4b. Since FI requires cofactors for its activity we also investigated the binding of purified cofactors C4BP and FH and found acquisition of both proteins, which retained their activity in FI mediated degradation of C3b and C4b. We propose that FI binding by P. intermedia represents a new mechanism contributing to complement evasion by a Gram-negative bacterial pathogen associated with chronic diseases