How Do Craft Beer Brands Negotiate Authenticity Using Retro Branding?

Craft beer brands are booming. However, many craft beer brands employ exceedingly similar retro-evocative techniques to negotiate authenticity with consumers. This article explores how craft beer brands systematically use retro marketing as a tool to negotiate authenticity with customers, through a consumer culture theory (CCT) lens. Moreover, the article seeks to examine potential implications of this largely homogenous use of discursive retro branding and faux heritage practices among craft beer brands, in the context of consumer authenticity and enchantment. The article finds that the current largely homogenous discursive retro branding practices risk eroding authenticity and enchantment. As these branding practices entangle brand connotations in the minds of consumers, this article finds craft beer firms should employ further marketing activities beyond these retro branding initiatives to remain relevant. Furthermore, the findings also suggest that the forced point-of-sale for craft beers in a Swedish setting - Systembolaget - exerts a negative impact on craft brands’ ability to negotiate brand authenticity.MSc in Marketing and Consumptio

A potent complement factor C3–specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement

The complement system is a complex, carefully regulated proteolytic cascade for which suppression of aberrant activation is of increasing clinical relevance, and inhibition of the complement alternative pathway is a subject of intense research. Here, we describe the nanobody hC3Nb1 that binds to multiple functional states of C3 with subnanomolar affinity. The nanobody causes a complete shutdown of alternative pathway activity in human and murine serum when present in concentrations comparable with that of C3, and hC3Nb1 is shown to prevent proconvertase assembly, as well as binding of the C3 substrate to C3 convertases. Our crystal structure of the C3b-hC3Nb1 complex and functional experiments demonstrate that proconvertase formation is blocked by steric hindrance between the nanobody and an Asn-linked glycan on complement factor B. In addition, hC3Nb1 is shown to prevent factor H binding to C3b, rationalizing its inhibition of factor I activity. Our results identify hC3Nb1 as a versatile, inexpensive, and powerful inhibitor of the alternative pathway in both human and murine in vitro model systems of complement activation

Internationale økonomisk-politiske tiltag under covid-19-krisen

Exceptionally large monetary and fiscal policy measures have been implemented globally to counteract the adverse economic consequences of the covid-19 crisis. The analysis first provides an overview of some of the measures taken to support liquidity and lending in the US, Germany, Sweden and Denmark. It then focuses on fiscal measures in the countries' stimulus packages that support demand directly. Finally, the use of state aid in the EU during the crisis is examined

MOBILIZE

The aim of the MOBILIZE project is to empower patients with multimorbidity to take a more active role in their health care through a personalized exercise therapy and education program so that they may reduce symptoms of the individual conditions, increase quality of life and physical function and prevent development of other chronic conditions. Strong interdisciplinary collaboration involving many different scientific methodologies and a high degree of patient involvement throughout the entire research process are at the heart of the project to ensure relevance to the patients and the health care system and to make sure that the project is implementable in clinical practice afterwards. The MOBILIZE project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 801790)

Patient Voice: Living with multiple chronic conditions, how exercise helps me self-manage

Patient voice by Gregers Aagaard. Published in Br J Sports Med . 2021 Sep 7; bjsports-2021-104382. doi: 10.1136/bjsports-2021-10438