Au nom du Bon Dieu et du Buffalo: Metis Lived Catholicism on the Northern Plains

This dissertation argues that Metis lived Catholicism was a tool of identity formation, resistance to colonialism, and political action among bison hunters of the northern plains in the long nineteenth century. The Catholicity of Metis bison hunters quotidian is highlighted through the extensive Michif French written legacy of Turtle Mountain historian ChWeUm (William Jr.) Davis (1845-1937). Daviss biography anchors a Metis national memory, weaving stories and events from both sides of the Medicine Line. His life story and the religious experiences of his relatives come together to explain why some Metis people adhered to Catholicism and its practices. Sustained experiences of the divine helped Metis families adapt and resist the effects of settler colonialism on the northern plains, including the end of organized bison-hunting expeditions. This dissertation blends several methodologies social history, biography, ethnohistory, and social network analysis from the digital humanities to interrogate the history of Catholicism among Metis peoples

Individual Claims Reserving using Activation Patterns

The occurrence of a claim often impacts not one but multiple insurance coverages provided in the contract. To account for this multivariate feature, we propose a new individual claims reserving model built around the activation of the different coverages to predict the reserve amounts. Using the framework of multinomial logistic regression, we model the activation of the different insurance coverages for each claim and their development in the following years, i.e. the activation of other coverages in the later years and all the possible payments that might result from them. As such, the model allows us to complete the individual development of the open claims in the portfolio. Using a recent automobile dataset from a major Canadian insurance company, we demonstrate that this approach generates accurate predictions of the total reserves as well as of the reserves per insurance coverage. This allows the insurer to get better insights in the dynamics of his claims reserves.Comment: European Actuarial Journal (2023

Comparison of determinants of research knowledge utilization by practitioners and administrators in the field of child and family social services

<p>Abstract</p> <p>Background</p> <p>An important gap exists between research production and its utilization. Few studies have examined the factors affecting knowledge utilization in the field of child and family social services.</p> <p>Methods</p> <p>The objectives of the study are to describe knowledge utilization by child protection administrators and practitioners (N = 477) and to compare factors related to knowledge utilization by these two occupational groups. The study was conducted with an adapted version of the <it>Questionnaire sur l'utilisation des connaissances </it>(Knowledge Utilization Questionnaire). Factor analysis was used to collapse data collected on the questionnaire items. Factor score for each respondent served as independent variables in three separate multivariate regression analyses to explore variables likely to predict research-based knowledge utilization.</p> <p>Results</p> <p>A minority of respondents (18%) report using on a frequent basis research-based knowledge in their practice. Relational capital between researchers and users and perceived usefulness of research based knowledge were the two factors most strongly related to utilization. There was a specificity in the factors associated with knowledge utilization according to occupational groups in child protection organizations. Use of active knowledge transfer strategies was associated with knowledge utilization by practitioners, while knowledge dissemination efforts played a more significant role for administrators.</p> <p>Conclusion</p> <p>These results encourage both the use of strategies differentiated according to users and the intensification of interactions between users and researchers to foster research knowledge utilization.</p

Audiometric Assessment for Children aged 6 to 60 months

This protocol addresses procedures for audiometric assessment of hearing thresholds in infants and young children using behavioural measures of threshold and associated measures in a test battery. The scope of this document includes these assessments as funded by MCCSS for the Ontario Infant Hearing Program (IHP). In infants and young children, modified operant conditioning is used to obtain systematic behavioural responses to sound from older infants and young children. These conditioned responses are used as the basis of behavioural audiometry until the child is developmentally able to complete standard audiometry, at about 3 to 5 years of age in typically developing children (Sabo et al., 2003)

Risk factors for hearing loss in children: A systematic literature review and meta-analysis protocol

Background: Hearing loss in newborns and children is a public health concern, due to high prevalence and negative effects on their development. Early detection and intervention of childhood hearing loss may mitigate these negative effects. Population-based newborn hearing screening programs have been established worldwide to identify children at risk for congenital hearing loss and to follow children at risk for late onset or progressive hearing loss. This article presents the protocol for a systematic review that aims to review the risk factors associated with permanent hearing loss in children, including congenital, early, or late onset. Risk factors associated with progressive hearing loss will be investigated as a secondary aim. Methods: Scientific literature from the following databases will be investigated: MEDLINE, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R), Embase, and CINAHL. The primary outcome is a permanent bilateral or unilateral hearing loss with congenital onset or onset during childhood (birth to 18 years). The secondary outcome is progressive hearing loss. Studies must report data on risk factors associated with permanent hearing loss; risk factors may be present at birth or later and result in immediate or delayed hearing loss. Randomized controlled trials, quasi-experimental studies, nonrandomized comparative and non-comparative studies, and case series will be included. The risk of bias will be assessed using the Qualitative Assessment Tool for Quantitative Studies (McMaster University). If aggregation of data is possible for a subsection of studies, we will pool data using meta-analysis techniques. If aggregation of data is not possible, a qualitative synthesis will be presented. We will assess the quality and strength of the overall body of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). The systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Discussion: The resulting information will inform the update of a provincial audiological surveillance protocol for the Ontario Infant Hearing Program and will be applicable to early hearing detection and intervention (EHDI) programs worldwide. Systematic review registration: We have registered the protocol in the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42018104121

Protocol for Universal Newborn Hearing Screening in Ontario

This document describes the Ontario Infant Hearing Program’s (IHP) protocol for universal newborn hearing screening (UNHS) of newborns and infants. It overrides all previous protocols on this subject provided by the IHP. The primary audience for this protocol is those who conduct newborn hearing screening within the IHP. All newborn and infant hearing screening funded by the Ontario Ministry of Children, Community and Social Services (MCCSS) must be carried out in full accordance with this protocol. It is based on continuous review of the best available scientific and clinical evidence and expert consultation complemented by consultation and collaboration with other major Early Hearing Detection and Intervention (EHDI) programs in Canada and worldwide

Protocol for Auditory Brainstem Response-Based Audiological Assessment (ABRA)

This protocol document includes a tabular synopsis of all key protocol elements, followed by expanded sections that may include additional details, rationale, challenges,and solutions for each topic area,plus appendices with selected references and further technical or procedural specifications.There are numerous changes from the 2016 Infant Hearing Program Audiologic Assessment document; the most important areas of change or emphasis are indicated by shading of the topic section number.The following synopsis can stand alone as a summary of the current ABRA protocol including all changes from previous versions.Areas within the 2008 IHP Assessment Protocol that relate to the protocol for Visual Reinforcement Audiometry (VRA) and Conditioned Play Audiometry(CPA) are included in the Protocol for Audiometric Assessment for Children Aged 6 to 60 months

A [3]Ferrocenophane polyphenol showing a remarkable antiproliferative activity on breast and prostate cancer cell lines

International audienc

The HIF1α/JMY pathway promotes glioblastoma stem-like cell invasiveness after irradiation

Human glioblastoma (GBM) is the most common primary malignant brain tumor. A minor subpopulation of cancer cells, known as glioma stem-like cells (GSCs), are thought to play a major role in tumor relapse due to their stem cell-like properties, their high resistance to conventional treatments and their high invasion capacity. We show that ionizing radiation specifically enhances the motility and invasiveness of human GSCs through the stabilization and nuclear accumulation of the hypoxia-inducible factor 1α (HIF1α), which in turn transcriptionally activates the Junction-mediating and regulatory protein (JMY). Finally, JMY accumulates in the cytoplasm where it stimulates GSC migration via its actin nucleation-promoting activity. Targeting JMY could thus open the way to the development of new therapeutic strategies to improve the efficacy of radiotherapy and prevent glioma recurrence.The authors thank members of the LRP for helpful discussions and are indebted to V. Barroca and the staff of the animal facilities and to N. Deschamps and J. Baijer for cell sorting. We also thanks I. Naguibneva for the gift of the pTRIP shHIF1α plasmid. MS is the recipient of a doctoral fellowship from the Ministère de la Recherche. This work was supported by grants from CEA (Segment Radiobiologie), La Ligue contre le Cancer (Comité d’Ile de France), Electricité de France (EDF), Fondation de France (N° Engt: 2013-00042632) and Ramón y Cajal program (RYC-2013-13450)

Use of Large Data Sets in Evaluating Program Outcome in Pediatric Hearing Loss

Introduction Permanent hearing loss (PHL) in childhood can profoundly impact development, with high economic costs to children and society. Hearing technology and service delivery advances, including universal newborn hearing screening implemented in Ontario in 2002 as part of the Infant Hearing Program (IHP), aim to improve outcomes of children with PHL. Objectives and Approach We examined the impact of IHP screening on age of identification of PHL, and compared healthcare utilization in children with and without PHL, in the Census Metropolitan Area of Ottawa. Children with PHL, identified from a database at the Children’s Hospital of Eastern Ontario, were linked to health administrative data housed at the Institute for Clinical Evaluative Sciences. Five residents of Ottawa acted as non-PHL controls for each PHL case. A regression discontinuity design (RDD) was used to investigate differences in age of identification pre- and post-IHP implementation. Poisson regression will compare healthcare utilization among children with and without PHL. Results Receipt of the HBPB was associated with reductions in low birth weight births (adjusted Relative Risk (aRR): 0.77; 95% CI: 0.63, 0.93) and preterm births (aRR: 0.78 (0.68, 0.90)), and increases in breastfeeding initiation (aRR: 1.05 (1.00, 1.09)) and large-for-gestational age births (aRR: 1.11 (1.01, 1.23)). HBPB receipt during pregnancy was also associated with increases in 1- and 2-year immunizations for FN children (aRR: 1.14 (1.09, 1.19), and aRR: 1.28 (1.19, 1.36), respectively). Reductions in the risk of being developmentally vulnerable in the language and cognitive domain of the EDI were also found for FN children whose mothers had received the HBPB during pregnancy (aRR: 0.85 (0.74, 0.97). Conclusion/Implications IHP implementation resulted in earlier identificationof PHL in children, allowing earlier access to audiologic and habilitative services. However, children with PHL used the health system more often and in different ways from those without PHL. These results can support improvements in service delivery for children with PHL