Anomalous gas in ESO 149-G003: A MeerKAT-16 view

ESO 149-G003 is a close-by, isolated dwarf irregular galaxy. Previous observations with the ATCA indicated the presence of anomalous neutral hydrogen (H I) deviating from the kinematics of a regularly rotating disc. We conducted follow-up observations with the MeerKAT radio telescope during the 16-dish Early Science programme as well as with the MeerLICHT optical telescope. Our more sensitive radio observations confirm the presence of anomalous gas in ESO 149-G003, and further confirm the formerly tentative detection of an extraplanar H I component in the galaxy. Employing a simple tilted-ring model, in which the kinematics is determined with only four parameters but including morphological asymmetries, we reproduce the galaxy's morphology, which shows a high degree of asymmetry. By comparing our model with the observed H I, we find that in our model, we cannot account for a significant (but not dominant) fraction of the gas. From the differences between our model and the observed data cube, we estimate that at least 7-8 per cent of the H I in the galaxy exhibits anomalous kinematics, while we estimate a minimum mass fraction of less than 1 per cent for the morphologically confirmed extraplanar component

Design of the BRISC study: a multicentre controlled clinical trial to optimize the communication of breast cancer risks in genetic counselling

Background: Understanding risks is considered to be crucial for informed decision-making. Inaccurate risk perception is a common finding in women with a family history of breast cancer attending genetic counseling. As yet, it is unclear how risks should best be communicated in clinical practice. This study protocol describes the design and methods of the BRISC (Breast cancer RISk Communication) study evaluating the effect of different formats of risk communication on the counsellee's risk perception, psychological well-being and decision-making regarding preventive options for breast cancer. Methods and design: The BRISC study is designed as a pre-post-test controlled group intervention trial with repeated measurements using questionnaires. The intervention-an additional risk consultation-consists of one of 5 conditions that differ in the way counsellee's breast cancer risk is communicated: 1) lifetime risk in numerical format (natural frequencies, i.e. X out of 100), 2) lifetime risk in both numerical format and graphical format (population figures), 3) lifetime risk and age-related risk in numerical format, 4) lifetime risk and age-related risk in both numerical format and graphical format, and 5) lifetime risk in percentages. Condition 6 is the control condition in which no intervention is given (usual care). Participants are unaffected women with a family history of breast cancer attending one of three participating clinical genetic centres in the Netherlands. Discussion: The BRISC study allows for an evaluation of the effects of different formats of communicating breast cancer risks to counsellees. The results can be used to optimize risk communication in order to improve informed decision-making among women with a family history of breast cancer. They may also be useful for risk communication in other health-related services. Trial registration: Current Controlled Trials ISRCTNI4566836