Atrial and ventricular electrical and contractile remodelling and reverse remodelling due to chronic pacing-induced atrial fibrillation in horses : preliminary results

In humans, electrical and contractile reverse remodelling following restoration of sinus rhythm (SR) after a prolonged period of spontaneous atrial fibrillation (AF), requires several weeks. There is little known about this phenomenon in horses. In the present study, six healthy horses were instrumented with a neurostimulator and a pacemaker to maintain AF for four months by intermittent burst pacing and to study atrial and ventricular electrophysiology. AF became persistent in all horses after two to six weeks of burst pacing. Before, during and after the AF period, parameters, such as the atrial fibrillation cycle length, the right atrial and ventricular refractory period and vulnerability, such as inducing atrial arrythmias, atrial tachyarrythmias or maintaining AF, were determined. Two-dimensional echocardiography was used to measure atrial and ventricular contractility expressed as fractional shortening and size expressed as diameter and area. In two of the six horses, the procedure was discontinued due to an increased threshold (1 horse) and due to infection at the level of the pacemaker pocket (1 horse). In the four remaining horses, significant electrical and contractile remodelling compared to baseline values was observed from 48 hours onwards after AF induction. Upon restoration of SR with quindine sulfate, all electrical and contractile values returned to normal within one to two months. No ventricular remodelling was observed. Four months of pacing-induced AF resulted in electrical and contractile remodelling and reverse remodelling. The results suggest that pacing-induced chronic AF does not cause permanent damage and suggest that a resting period of six to eight weeks before returning to training might be beneficial

Herd-level animal management factors associated with the occurrence of bovine neonatal pancytopenia in calves in a multicountry study

Since 2007, mortality associated with a previously unreported haemorrhagic disease has been observed in young calves in several European countries. The syndrome, which has been named ‘bovine neonatal pancytopenia’ (BNP), is characterised by thrombocytopenia, leukocytopenia and a panmyelophthisis. A herd-level case-control study was conducted in four BNP affected countries (Belgium, France, Germany and the Netherlands) to identify herd management risk factors for BNP occurrence. Data were collected using structured face-to-face and telephone interviews of farm managers and their local veterinarians. In total, 363 case farms and 887 control farms were included in a matched multivariable conditional logistic regression analysis. Case-control status was strongly associated with the odds of herd level use of the vaccine PregSure® BVD (PregSure, Pfizer Animal Health) (matched adjusted odds ratio (OR) 107.2; 95% CI: 41.0–280.1). This was also the case for the practices of feeding calves colostrum from the calf’s own dam (OR 2.0; 95% CI: 1.1–3.4) or feeding pooled colostrum (OR 4.1; 95% CI: 1.9–8.8). Given that the study had relatively high statistical power and represented a variety of cattle production and husbandry systems, it can be concluded with some confidence that no other herd level management factors are competent causes for a sufficient cause of BNP occurrence on herd level. It is suggested that genetic characteristics of the dams and BNP calves should be the focus of further investigations aimed at identifying the currently missing component causes that together with PregSure vaccination and colostrum feeding represent a sufficient cause for occurrence of BNP in calves