1 research outputs found
Efficient Transposition of the Sandmeyer Reaction from Batch to Continuous Process
The
transposition of Sandmeyer chlorination from a batch to a safe
continuous-flow process was investigated. Our initial approach was
to develop a cascade method using flow chemistry which involved the
generation of a diazonium salt and its quenching with copper chloride.
To achieve this safe continuous process diazotation, a chemometric
approach (Simplex method) was used and extrapolated to establish a
fully continuous-flow method. The reaction scope was also examined
via the synthesis of several (het)Âaryl chlorides. Validation and scale-up
of the process were also performed. A higher productivity was obtained
with increased safety