Technological Capability and Productivity Growth: An Industrialized / Industrializing Country Comparison

The importance of technical change as a crucial element explaining inter-country differences in levels and rates of change in industrial productivity has been increasingly acknowledged. Hence, growing significance has been attached to developing the capability to generate such change. However, the perceived nature of that capability (described here as technological capability) and its links to productivity growth are still poorly understood. This paper empirically explores the links between (i) technological capability (the causal variable) (ii) the generation of technical changes (the intermediate variable) and (iii) productivity growth (the end-result variable). In particular, it examines organizational dimensions of technological capability. L'importance des changements techniques comme éléments clés expliquant les différences entre pays quant aux niveaux et aux taux de productivité industrielle est de plus en plus reconnue. En conséquence, il y a un intérêt croissant quant au développement des capacités nécessaires à de tels changements. Cependant, la nature de cette capacité (dite capacité technologique) et ses liens avec la croissance de productivité est encore peu comprise. Cet article explore empiriquement les liens entre (i) la capacité technologique (variable causale) (ii) la génération de changements techniques (variable intermédiaire) et (iii) la croissance de productivité (variable résultante). En particulier, il examine les dimensions organisationnelles de la capacité technologique.technological capability, organizational systems, technical change, productivity growth, pulp and paper, India, Canada, capacité technologique, systèmes organisationnels, changement technique, croissance de productivité, pâtes et papiers, Inde, Canada

Informal Thinkering: How Is It Important?

This paper examines innovation processes or technical change-generation processes at the firm level. It emphasizes the notion that the element of technical and technological change that is a determinant of productivity growth is strongly induced by internal factors related to the firm's behavior, via investment in R&D but also, and importantly, on the basis of informal thinkering within plants. This research is unique in that it seeks first, to examine the pattern of technical change and its ensuing productivity growth, and second, to make a comparison between an industrialized and an industrializing country. This comparison is conducted by empirically comparing mills in the pulp and paper manufacturing sector in two countries: Canada and India. The overall analysis is based on direct observations at the mill level, face-to-face interviews and on analysis of mill documentary records. This paper highlights the importance of managing change as a continuous process. The introduction of intermittent, step-jump technical changes contributed little to explain the differences in performance between the mills. Much more important are (i) the continuing sequences of smaller investments in technical change, often linked to the larger step-jumps, and (ii) the existence of steady streams of changes and improvements that are unrecorded as capital expenditure Cet article examine des processus d'innovation ou de génération de changements techniques au niveau de la firme. Il met l'emphase sur le fait que les paramètres clés connexes aux changements techniques et technologiques ayant un impact sur la croissance de productivité sont induits par des facteurs behavioraux internes à la firme. Les changements peuvent être le résultat d'investissement dans la R&D,0501s aussi, et de façon significative, le résultat de processus de conceptions informelles à l'intérieur des firmes. Cette recherche examiner dans un premier temps des processus de changements techniques et la croissance de productivité en résultant. Dans un deuxième temps, elle fait une analyse comparative entre pays industrialisés et s'industrialisant. Cette étude empirique est basée sur des données de première0501n (observations directes, entrevues personnelles, documents internes) collectées dans neuf usines de pâtes et papiers dans deux pays (Canada et Inde). Ce papier met en évidence l'importance de gérer le changement comme un processus continu. L'introduction de changements techniques par sauts intermittents contribue peu à expliquer les différences de croissance de productivité entre les usines. Plus significatives sont (i) les séquences continues de petits investissements (changements techniques), souvent liés aux plus grands changements par sauts, et (ii) l'existence d'un flux continu de changements et d'améliorations qui ne sont pas officiellement enregistrés (aux livres, de façon comptable) comme des investissements en capitaux.Technical change, incremental change, performance measure-ment, continuous improvement, capital investment, pulp and paper, India, Canada, Changement technique, changements par incréments, mesures de performance, amélioration continue, investment capital, pâtes et papiers, Inde, Canada

The Dividing Line between Federal and State Promotion of Aeronautics

<p>The model xeno-estrogen bisphenol A (BPA) has been extensively studied over the past two decades, contributing to major advances in the field of endocrine disrupting chemicals research. Besides its well documented adverse effects on reproduction and development observed in rodents, latest studies strongly suggest that BPA disrupts several endogenous metabolic pathways, with suspected steatogenic and obesogenic effects. BPA's adverse effects on reproduction are attributed to its ability to activate estrogen receptors (ERs), but its effects on metabolism and its mechanism(s) of action at low doses are so far only marginally understood. Metabolomics based approaches are increasingly used in toxicology to investigate the biological changes induced by model toxicants and chemical mixtures, to identify markers of toxicity and biological effects. In this study, we used proton nuclear magnetic resonance (¹H-NMR) based untargeted metabolite profiling, followed by multivariate statistics and computational analysis of metabolic networks to examine the metabolic modulation induced in human hepatic cells (HepG2) by an exposure to low and very low doses of BPA (10⁻⁶M, 10⁻⁹M, and 10⁻¹²M), vs. the female reference hormone 17β-estradiol (E2, 10⁻⁹M, 10⁻¹²M, and 10⁻¹⁵M). Metabolomic analysis combined to metabolic network reconstruction highlighted different mechanisms at lower doses of exposure. At the highest dose, our results evidence that BPA shares with E2 the capability to modulate several major metabolic routes that ensure cellular functions and detoxification processes, although the effects of the model xeno-estrogen and of the natural hormone can still be distinguished.</p

Conductance Distributions in Random Resistor Networks: Self Averaging and Disorder Lengths

The self averaging properties of conductance $g$ are explored in random resistor networks with a broad distribution of bond strengths P(g)\simg^{\mu-1}. Distributions of equivalent conductances are estimated numerically on hierarchical lattices as a function of size $L$ and distribution tail parameter $\mu$. For networks above the percolation threshold, convergence to a Gaussian basin is always the case, except in the limit $\mu$ --> 0. A {\it disorder length} $\xi_D$ is identified beyond which the system is effectively homogeneous. This length diverges as $\xi_D \sim |\mu|^{-\nu}$ ($\nu$ is the regular percolation correlation length exponent) as $\mu$-->0. This suggest that exactly the same critical behavior can be induced by geometrical disorder and bu strong bond disorder with the bond occupation probability $p$$\mu$. Only lattices at the percolation threshold have renormalized probability distribution in a {\it Levy-like} basin. At the threshold the disorder length diverges at a vritical tail strength $\mu_c$ as $|\mu-\mu_c|^{-z}$, with $z=3.2\pm 0.1$, a new exponent. Critical path analysis is used in a generalized form to give form to give the macroscopic conductance for lattice above $p_c$.Comment: 16 pages plain TeX file, 6 figures available upon request.IBC-1603-01

Natural history and determinants of dysglycemia in Canadian children with parental obesity from ages 8–10 to 15–17 years : the QUALITY cohort

In children, the mechanisms implicated in deterioration of glucose homeostasis versus reversion to normal glucose tolerance (NGT) remain uncertain. We aimed to describe the natural history of dysglycemia from childhood to late adolescence and to identify its early determinants. We used baseline (8–10 years, n = 630), 1st follow-up (10–12 years, n = 564) and 2nd follow-up (15–17 years, n = 377) data from the QUALITY cohort of White Canadian children with parental obesity. Children underwent a 2-h oral glucose tolerance test at each cycle with plasma glucose and insulin measured at 0/30/60/90/120 min. American Diabetes Association criteria defined dysglycemia (impaired fasting glucose, impaired glucose tolerance or type 2 diabetes). Longitudinal patterns of insulin sensitivity and beta-cell function were estimated using generalized additive mixed models. Model averaging identified biological, sociodemographic and lifestyle-related determinants of dysglycemia. Of the children NGT at baseline, 66 (21%) developed dysglycemia without reverting to NGT. Among children with dysglycemia at baseline, 24 (73%) reverted to NGT. In children with dysglycemia at 1st follow-up, 18 (53%) later reverted to NGT. Among biological, sociodemographic and lifestyle determinants at 8–10 years, only fasting and 2-h glucose were associated with developing dysglycemia (odds ratio [95% CI] per 1 mmol/L increase: 4.50 [1.06; 19.02] and 1.74 [1.11; 2.73], respectively). Beta-cell function decreased by 40% in children with overweight or obesity. In conclusion, up to 75% of children with dysglycemia reverted to NGT during puberty. Children with higher fasting and 2-h glucose were at higher risk for progression to dysglycemia, while no demographic/lifestyle determinants were identified

Surface Hardness Impairment of Quorum Sensing and Swarming for Pseudomonas aeruginosa

The importance of rhamnolipid to swarming of the bacterium Pseudomonas aeruginosa is well established. It is frequently, but not exclusively, observed that P. aeruginosa swarms in tendril patterns—formation of these tendrils requires rhamnolipid. We were interested to explain the impact of surface changes on P. aeruginosa swarm tendril development. Here we report that P. aeruginosa quorum sensing and rhamnolipid production is impaired when growing on harder semi-solid surfaces. P. aeruginosa wild-type swarms showed huge variation in tendril formation with small deviations to the “standard” swarm agar concentration of 0.5%. These macroscopic differences correlated with microscopic investigation of cells close to the advancing swarm edge using fluorescent gene reporters. Tendril swarms showed significant rhlA-gfp reporter expression right up to the advancing edge of swarming cells while swarms without tendrils (grown on harder agar) showed no rhlA-gfp reporter expression near the advancing edge. This difference in rhamnolipid gene expression can be explained by the necessity of quorum sensing for rhamnolipid production. We provide evidence that harder surfaces seem to limit induction of quorum sensing genes near the advancing swarm edge and these localized effects were sufficient to explain the lack of tendril formation on hard agar. We were unable to artificially stimulate rhamnolipid tendril formation with added acyl-homoserine lactone signals or increasing the carbon nutrients. This suggests that quorum sensing on surfaces is controlled in a manner that is not solely population dependent