Eliminating Human African Trypanosomiasis: Where Do We Stand and What Comes Next>

While the number of new detected cases of HAT is falling, say the authors, sleeping sickness could suffer the "punishment of success," receiving lower priority by public and private health institutions

The identification of Trypanosoma brucei subspecies using repetitive DNA sequences

We describe the use of repetitive DNA probes to characterise the relationships between different stocks of African trypanosomes representing the subspecies of Trypanosoma brucei. Probes derived from the ribosomal RNA genes (coding region and non-transcribed spacer) and another repetitive DNA sequence were used to characterise trypanosome stocks by Southern blotting. Numerical taxonomy methods applied to the resulting restriction enzyme patterns were used to derive a dendrogram depicting the relationships between the stocks examined. We show that three groups of West African human infective stocks can be distinguished: firstly, a group containing exclusively T. b. gambiense; secondly, a group which is indistinguishable from animal isolates in West Africa; and thirdly, a single stock which is indistinguishable from East African T. b. rhodesiense. In addition, we observe that T. b. rhodesiense stocks from East Africa are indistinguishable from animal isolates from the same area. Finally, we show that a group of T. b. rhodesiense stocks, isolated from a 1978 sleeping sickness outbreak in Zambia, are probably derived from a single parasite strain, and that this strain is distinct from T. b. rhodesiense parasites from Kenya and Uganda

T. b. gambiense: Comparative Evolution Curves between Population Placed Under Active Surveillance and New Cases Reported (1997–2006)

<p>T. b. gambiense: Comparative Evolution Curves between Population Placed Under Active Surveillance and New Cases Reported (1997–2006)</p

New Cases of Sleeping Sickness Reported for All Africa between 1927 and 1997

<p>New Cases of Sleeping Sickness Reported for All Africa between 1927 and 1997</p

HAT Transmission Cycle

<p>In T. b. gambiense the cycle is mostly human-to-human (central circle); occasionally transmission may occur from animal to human. In T. b. rhodesiense the animal reservoir plays an important role in the cycle, thus sustaining parasite transmission and human infections.</p

Le misanthrope / Molière, aut. ; Jean-Louis Barrault (Alceste), Madeleine Renaud (Célimène), Pierre Bertin (Oronte), Jean Desailly (Philinte)... [et al.], voix

[Le misanthrope (français)]BnF-Partenariats, Collection sonore - BelieveContient une table des matière