Mesure de la section efficace d'interaction des neutrinos muoniques par courant chargé sur du carbone, sans production de pions dans l'état final et en fonction de la multiplicité et de la cinématique des particules produites, en utilisant le détecteur proche de T2K

Since the Higgs boson discovery and the absence of hints pointing to new physics at the LHC, neutrinos oscillations are one of the only perspectives to observe new physics phenomenon beyond the standard model. The first chapter of this thesis introduces the concept of neutrino flavour oscillation before describing the state of the art knowledges as well as the experimental perspectives of observing or measuring the missing parts.To obtain significant results, those future experiments will need a better understanding of neutrino interactions. The second chapter describes these interactions from a theoretical point of view. The third one describes the T2K experiment and its main results on neutrino oscillations. Chapter four focus on the T2K near detector (ND280) and on how it is used within neutrino oscillations analysis. The angular acceptance of the current ND280 selection is limited compared to the far detector one. Chapter 5 describes two selections developed in order to improve this angular acceptance. This chapter also describes the selection used to carry out this thesis main work : the cross-section measurement of muon neutrino charged current interactions on Carbon, with no pions in the final state and as a function of the outgoing particles multiplicity and kinematics. Chapter six describes this measurement, designed to be as model independent as possible, and made for the first time as a function of the protons multiplicity and of their kinematic. The results are shown in chapter seven.Depuis la confirmation de l’existence du boson de Higgs et avec l’absence de signes de nouvelle physique au LHC, les oscillations des neutrinos sont parmi les seules à offrir des perspectivesd’observation et de mesure de phénomènes de nouvelle physique au delà du modèle standard.Le premier chapitre de cette thèse introduit le concept d’oscillation de saveur des neutrinospuis décrit l’état de l’art des connaissances ainsi que les perspectives expérimentales pour mesurer ou observer les pièces manquantes.Pour obtenir des résultats significatifs, ces futures expériences auront besoin de pouvoir profiter d’une meilleure compréhension des processus d’interaction des neutrinos. Le second chapitre décrit ces interactions d’un point de vu théorique.Le troisième chapitre présente l’expérience T2K ainsi que ses résultats sur les oscillationsdes neutrinos. Le quatrième décrit plus précisément le détecteur proche de T2K (ND280) etl’usage qu’on en fait dans les analyses d’oscillations.La couverture angulaire de la sélection des interactions dans le détecteur proche de T2K estlimitée par rapport à celle, complète, du détecteur lointain. Le chapitre 5 décrit deux sélections visant à améliorer cette couverture, ainsi que celle utilisée pour réaliser, dans le cadre de cette thèse, la mesure de la section efficace d’interaction des neutrinos muoniques par courant chargé sur le carbone sans production de pions dans l’état final.Le chapitre 6 décrit cette mesure, conçue pour ne pas dépendre de modèles théoriques d’interaction, et réalisée pour la première fois en fonction du nombre de protons éjectés et de leur cinématique. Les résultats sont montrés dans le chapitre 7

Cross-section measurement of muon neutrino charged current interactions on Carbon, with no pions in the final state and as a function of the outgoing particles multiplicity and kinematics, using the T2K near detector

Depuis la confirmation de l’existence du boson de Higgs et avec l’absence de signes de nouvelle physique au LHC, les oscillations des neutrinos sont parmi les seules à offrir des perspectivesd’observation et de mesure de phénomènes de nouvelle physique au delà du modèle standard.Le premier chapitre de cette thèse introduit le concept d’oscillation de saveur des neutrinospuis décrit l’état de l’art des connaissances ainsi que les perspectives expérimentales pour mesurer ou observer les pièces manquantes.Pour obtenir des résultats significatifs, ces futures expériences auront besoin de pouvoir profiter d’une meilleure compréhension des processus d’interaction des neutrinos. Le second chapitre décrit ces interactions d’un point de vu théorique.Le troisième chapitre présente l’expérience T2K ainsi que ses résultats sur les oscillationsdes neutrinos. Le quatrième décrit plus précisément le détecteur proche de T2K (ND280) etl’usage qu’on en fait dans les analyses d’oscillations.La couverture angulaire de la sélection des interactions dans le détecteur proche de T2K estlimitée par rapport à celle, complète, du détecteur lointain. Le chapitre 5 décrit deux sélections visant à améliorer cette couverture, ainsi que celle utilisée pour réaliser, dans le cadre de cette thèse, la mesure de la section efficace d’interaction des neutrinos muoniques par courant chargé sur le carbone sans production de pions dans l’état final.Le chapitre 6 décrit cette mesure, conçue pour ne pas dépendre de modèles théoriques d’interaction, et réalisée pour la première fois en fonction du nombre de protons éjectés et de leur cinématique. Les résultats sont montrés dans le chapitre 7.Since the Higgs boson discovery and the absence of hints pointing to new physics at the LHC, neutrinos oscillations are one of the only perspectives to observe new physics phenomenon beyond the standard model. The first chapter of this thesis introduces the concept of neutrino flavour oscillation before describing the state of the art knowledges as well as the experimental perspectives of observing or measuring the missing parts.To obtain significant results, those future experiments will need a better understanding of neutrino interactions. The second chapter describes these interactions from a theoretical point of view. The third one describes the T2K experiment and its main results on neutrino oscillations. Chapter four focus on the T2K near detector (ND280) and on how it is used within neutrino oscillations analysis. The angular acceptance of the current ND280 selection is limited compared to the far detector one. Chapter 5 describes two selections developed in order to improve this angular acceptance. This chapter also describes the selection used to carry out this thesis main work : the cross-section measurement of muon neutrino charged current interactions on Carbon, with no pions in the final state and as a function of the outgoing particles multiplicity and kinematics. Chapter six describes this measurement, designed to be as model independent as possible, and made for the first time as a function of the protons multiplicity and of their kinematic. The results are shown in chapter seven

Validation of the Withings Sleep Analyzer, an under-the-mattress device for the detection of moderate-severe sleep apnea syndrome

Study Objectives: To assess the diagnostic performance of a nonintrusive device placed under the mattress to detect sleep apnea syndrome. Methods: One hundred eighteen patients suspected to have obstructive sleep apnea syndrome completed a night at a sleep clinic with a simultaneous polysomnography (PSG) and recording with the Withings Sleep Analyzers. PSG nights were scored twice: First as simple polygraphy, then as PSG. Results: Average (standard deviation) apnea-hypopnea index from PSG was 31.2 events/h (25.0) and 32.8 events/h (29.9) according to the Withings Sleep Analyzers. The mean absolute error was 9.5 events/h. The sensitivity, specificity, and area under the receiver operating characteristic curve at thresholds of apnea-hypopnea index ≥ 15 events/h were, respectively, sensitivity (Se)15 = 88.0%, specificity (Sp)15 = 88.6%, and area under the receiver operating characteristic curve (AUROC) 15 = 0.926. At the threshold of apnea-hypopnea index ≥ 30 events/h, results included Se30 = 86.0%, Sp30 = 91.2%, AUROC30 = 0.954. The average total sleep time from PSG and the Withings Sleep Analyzers was 366.6 (61.2) and 392.4 (67.2) minutes, sleep efficiency was 82.5% (11.6) and 82.6% (11.6), and wake after sleep onset was 62.7 (48.0) and 45.2 (37.3) minutes, respectively. Conclusions:Withings Sleep Analyzers accurately detect moderate-severe sleep apnea syndrome in patients suspected of sleep apnea syndrome. This simple and automated approach could be of great clinical value given the high prevalence of sleep apnea syndrome in the general population.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Atrial Fibrillation Detection With an Analog Smartwatch: Prospective Clinical Study and Algorithm Validation

BackgroundAtrial fibrillation affects approximately 4% of the world’s population and is one of the major causes of stroke, heart failure, sudden death, and cardiovascular morbidity. It can be difficult to diagnose when asymptomatic or in the paroxysmal stage, and its natural history is not well understood. New wearables and connected devices offer an opportunity to improve on this situation. ObjectiveWe aimed to validate an algorithm for the automatic detection of atrial fibrillation from a single-lead electrocardiogram taken with a smartwatch. MethodsEligible patients were recruited from 4 sites in Paris, France. Electrocardiograms (12-lead reference and single lead) were captured simultaneously. The electrocardiograms were reviewed by independent, blinded board-certified cardiologists. The sensitivity and specificity of the algorithm to detect atrial fibrillation and normal sinus rhythm were calculated. The quality of single-lead electrocardiograms (visibility and polarity of waves, interval durations, heart rate) was assessed in comparison with the gold standard (12-lead electrocardiogram). ResultsA total of 262 patients (atrial fibrillation: n=100, age: mean 74.3 years, SD 12.3; normal sinus rhythm: n=113, age: 61.8 years, SD 14.3; other arrhythmia: n=45, 66.9 years, SD 15.2; unreadable electrocardiograms: n=4) were included in the final analysis; 6.9% (18/262) were classified as Noise by the algorithm. Excluding other arrhythmias and Noise, the sensitivity for atrial fibrillation detection was 0.963 (95% CI lower bound 0.894), and the specificity was 1.000 (95% CI lower bound 0.967). Visibility and polarity accuracies were similar (1-lead electrocardiogram: P waves: 96.9%, QRS complexes: 99.2%, T waves: 91.2%; 12-lead electrocardiogram: P waves: 100%, QRS complexes: 98.8%, T waves: 99.5%). P-wave visibility accuracy was 99% (99/100) for patients with atrial fibrillation and 95.7% (155/162) for patients with normal sinus rhythm, other arrhythmias, and unreadable electrocardiograms. The absolute values of the mean differences in PR duration and QRS width were <3 ms, and more than 97% were <40 ms. The mean difference between the heart rates from the 1-lead electrocardiogram calculated by the algorithm and those calculated by cardiologists was 0.55 bpm. ConclusionsThe algorithm demonstrated great diagnostic performance for atrial fibrillation detection. The smartwatch’s single-lead electrocardiogram also demonstrated good quality for physician use in daily routine care. Trial RegistrationClinicalTrials.gov NCT04351386; http://clinicaltrials.gov/ct2/show/NCT0435138

Combined Analysis of Neutrino and Antineutrino Oscillations at T2K

T2K reports its first results in the search for CP violation in neutrino oscillations using appearance and disappearance channels for neutrino- and antineutrino-mode beams. The data include all runs from January 2010 to May 2016 and comprise 7.482 ×10^(20) protons on target in neutrino mode, which yielded in the far detector 32 e-like and 135 μ-like events, and 7.471 × 10^(20) protons on target in antineutrino mode, which yielded 4 e-like and 66 μ-like events. Reactor measurements of sin(2)2θ(13) have been used as an additional constraint. The one-dimensional confidence interval at 90% for the phase δCP spans the range (−3.13, −0.39) for normal mass ordering. The CP conservation hypothesis (δCP = 0, π) is excluded at 90% C.L.ISSN:0031-9007ISSN:1079-711