Surface water flood forecasting for urban communities

Key findings and recommendations: • This research has addressed the challenge of surface water flood forecasting by producing the UK’s first operational surface water flood risk forecast with a 24-hour lead time. This was successfully used in Glasgow at the Commonwealth Games in 2014. • The methodology of the Glasgow Pilot has been developed to use nationally available datasets and a transferrable approach which will help urban areas in Scotland improve their resilience to and preparedness for future flooding. • It also delivered a novel method for forecasting the impacts of flooding in real-time and increased knowledge on communicating uncertainties in flood risk. • A real-time forecasting system for surface water flooding from intense rainfall needs to use models that represent surface runoff production, surface water inundation and movement, and how water travels via surface and sub-surface pathways, including urban sewerage and drainage networks. Ensemble rainfall prediction models are key to quantifying uncertainty in forecasting the rainfall that causes surface water flooding. • Detailed surface water flood inundation models exist and are widely used in design and research activities, but none were found to be ready for real-time use. The Grid-to-Grid (G2G) distributed hydrological model was chosen for used in the Glasgow Pilot as it can provide ensemble forecasts of surface water flooding, and takes account of the intensity and pattern of rainfall, land cover and slope, and antecedent conditions. • The research developed a novel methodology for impact assessment that links surface runoff to the severity of flooding impacts on people, property and transport. Use is made of a library of information based on SEPA’s Regional Pluvial (rainfall-related) Flood Hazard maps. • For the Glasgow Pilot, G2G was operated over a 10km by 10km area encompassing Glasgow’s East End and the main areas of activity for the 2014 Commonwealth Games. The research team developed an operational application, called FEWS Glasgow, to support running the model in real-time and reporting on the likely impacts of surface water flooding. A new Daily Glasgow Daily Surface Water Flood Forecast was designed and produced based on operational requirements and emergency responder feedback

Temperature-dependent NMR features of the Al65Cu20Ru15 icosahedral alloy

The Al65Cu20Ru15 icosahedral alloy was studied by Al27 nuclear magnetic resonance from 150 to 1110 K. The Knight shift of the unresolved resonance line was observed to significantly increase above 500 K. This uncommon temperature dependence of the Knight shift is interpreted in terms of the presence of a pseudogap at the Fermi level. The spin-lattice relaxation rate deviates from the linear temperature dependence of Korringa relaxation below 500 K, and above 500 K it is dominated by a thermally activated process with a small activation energy of 0.48 eV. This energy is distinctly different from the activation energy observed in simple metallic alloys

Mental health academics in rural and remote Australia

Context: The significant impact of mental ill health in rural and remote Australia has been well documented. Included among innovative approaches undertaken to address this issue has been the Mental Health Academic (MHA) project, established in 2007. Funded by the Australian Government (Department of Health), this project was established as a component of the University Departments of Rural Health (UDRH) program. All 11 UDRHs appointed an MHA. Although widely geographically dispersed, the MHAs have collaborated in various ways. The MHA project encompasses a range of activities addressing four key performance indicators. These activities, undertaken in rural and remote Australia, aimed to increase access to mental health services, promote awareness of mental health issues, support students undertaking mental health training and improve health professionals' capacity to recognise and address mental health issues. MHAs were strategically placed within the UDRHs across the country, ensuring an established academic base for the MHAs' work was available immediately. Close association with each local rural community was recognised as important. For most MHAs this was facilitated by having an established clinical role in their local community and actively engaging with the community in which they worked. In common with other rural health initiatives, some difficulties were experienced in the recruitment of suitable MHAs, especially in more remote locations. The genesis of this article was a national meeting of the MHAs in 2014, to identify and map the different types of activities MHAs had undertaken in their regions. These activities were analysed and categorised by the MHAs. These categories have been used as a guiding framework for this article. Issues: The challenge to increase community access to mental health services was addressed by (i) initiatives to address specific access barriers, (ii) supporting recruitment and retention of rural mental health staff, (iii) developing the skills of the existing workforce and (iv) developing innovative approaches to student placements. Strategies to promote awareness of mental health issues included workshops in rural and remote communities, specific suicide prevention initiatives and targeted initiatives to support the mental health needs of Indigenous Australians. The need for collaboration between the widely dispersed MHAs was identified as important to bridge the rural divide, to promote project cohesiveness and ensure new ideas in an emerging setting are readily shared and to provide professional support for one another as mental health academics are often isolated from academic colleagues with similar mental health interests. Lessons learned: The MHA project suggests that an integrated approach can be taken to address the common difficulties of community awareness raising of mental health issues, increasing access to mental health services, workforce recruitment and retention (access), and skill development of existing health professionals (access and awareness). To address the specific needs and circumstances of their community, MHAs have customised their activities. As in other rural initiatives, one size was found not to fit all. The triad of flexibility, diversity and connectedness (both to local community and other MHAs) describes the response identified as appropriate by the MHAs. The breadth of the MHA role to provide university sponsored educational activities outside traditional student teaching meant that the broader health workforce benefited from access to mental health training that would not otherwise have occurred. Provision of these additional educational opportunities addressed not only the need for increased education regarding mental health but also reduced the barriers commonly faced by rural health professionals in accessing quality professional development

Parametrization of nonlinear and chaotic oscillations in driven beam-plasma diodes

Nonlinear phenomena in a driven plasma diode are studied using a fluid code and the particle-in-cell simulation code XPDPI. When a uniform electron beam is injected to a bounded diode filled with uniform ion background, the beam is destabilized by the Pierce instability and a perturbation grows to exhibit nonlinear oscillations including chaos. Two standard routes to chaos, period doubling and quasiperiodicity, are observed. Mode lockings of various winding numbers are observed in an ac driven system. A new diagnostic quantity is used to parametrize various nonlinear oscillations.open10

Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major

Background The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in a wide range of pathogenic microorganisms. It has previously been demonstrated that small-molecule compounds designed to target Mip from the Gram-negative bacterium Burkholderia pseudomallei bind at the site of enzymatic activity of the protein, inhibiting the in vitro activity of Mip. Objectives In this study, co-crystallography experiments with recombinant B. pseudomallei Mip (BpMip) protein and Mip inhibitors, biochemical analysis and computational modelling were used to predict the efficacy of lead compounds for broad-spectrum activity against other pathogens. Methods Binding activity of three lead compounds targeting BpMip was verified using surface plasmon resonance spectroscopy. The determination of crystal structures of BpMip in complex with these compounds, together with molecular modelling and in vitro assays, was used to determine whether the compounds have broad-spectrum antimicrobial activity against pathogens. Results Of the three lead small-molecule compounds, two were effective in inhibiting the PPIase activity of Mip proteins from Neisseria meningitidis, Klebsiella pneumoniae and Leishmania major. The compounds also reduced the intracellular burden of these pathogens using in vitro cell infection assays. Conclusions These results indicate that Mip is a novel antivirulence target that can be inhibited using small-molecule compounds that prove to be promising broad-spectrum drug candidates in vitro. Further optimization of compounds is required for in vivo evaluation and future clinical applications

The effect of autonomy, training opportunities, age and salaries on job satisfaction in the South East Asian retail petroleum industry

South East Asian petroleum retailers are under considerable pressure to improve service quality by reducing turnover. An empirical methodology from this industry determined the extent to which job characteristics, training opportunities, age and salary influenced the level of job satisfaction, an indicator of turnover. Responses are reported on a random sample of 165 site employees (a 68% response rate) of a Singaporean retail petroleum firm. A restricted multivariate regression model of autonomy and training opportunities explained the majority (35.4%) of the variability of job satisfaction. Age did not moderate these relationships, except for employees >21 years of age, who reported enhanced job satisfaction with additional salary. Human Capital theory, Life Cycle theory and Job Enrichment theory are invoked and explored in the context of these findings in the South East Asian retail petroleum industry. In the South East Asian retail petroleum industry, jobs providing employees with the opportunity to undertake a variety of tasks that enhanced the experienced meaningfulness of work are likely to promote job satisfaction, reduce turnover and increase the quality of service

L-glutamine and L-glutamate in diets with different lactose levels for piglets weaned at 21 days of age

This study was developed to evaluate the effects of adding L-glutamine and L-glutamate in diets with no lactose or with 4.0 or 8.0% lactose inclusion for piglets weaned at 21 days old. One hundred and eight piglets with initial weight of 6.12±0.70 kg were allotted in a complete randomized block design, in a 3 × 2 factorial arrangement, with six treatments, six replicates, and three piglets per experimental unit. The experimental diets were supplied from 21 to 35 days. From 36 to 49 days, animals received the same diet with no lactose inclusion, but the animals in the treatments with L-glutamine + L-glutamate in the previous phase continued to receive diets containing these ingredients. There was no interaction between the level of lactose and the inclusion of L-glutamine + L-glutamate on the parameters evaluated. The levels of lactose did not affect the performance of piglets in either of the two periods. Adding L-glutamine and L-glutamate in the diet positively influenced the weight gain of pigs from 21 to 49 days of age and increased the villous height in the duodenum, jejunum and ileum. Inclusion of L-glutamine + L-glutamate in diets for piglets weaned at 21 days of age improves the performance and the intestinal mucosa morphology, regardless of lactose addition

Diving into the vertical dimension of elasmobranch movement ecology

Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements