Weak Isospin Violations in Charged and Neutral Higgs Couplings from SUSY Loop Corrections

Supersymmetric QCD and supersymmetric electroweak loop corrections to the violations of weak isospin to Yukawa couplings are investigated. Specifically it involves an analysis of the supersymmetric loop corrections to the Higgs couplings to the third generation quarks and leptons. Here we analyze the SUSY loop corrections to the charged Higgs couplings which are then compared with the supersymmetric loop corrections to the neutral Higgs couplings previously computed. It is found that the weak isospin violations can be quite significant, i.e, as much as 40-50% or more of the total loop correction to the Yukawa coupling. The effects of CP phases are also studied and it is found that these effects can either enhance or suppress the weak isospin violations. We also investigate the weak isospin violation effects on the branching ratio $BR(H^-\to\bar t b)/ BR(H^-\to \bar\nu_{\tau}\tau^-)$ and show that the effects are sensitive to CP phases. Thus an accurate measurement of this branching ratio along with the branching ratio of the neutral Higgs boson decays can provide a measure of weak isospin violation along with providing a clue to the presence of supersymmetry.Comment: 20 pages, 9 figure

The anomalous Higgs-top couplings in the MSSM

The anomalous couplings of the top quark and the Higgs boson has been studied in an effective theory resulting in the framework of the minimal supersymmetric extension of the standard model (MSSM) when the heavy fields are integrated out. Constraints on the parameters of the model from the experimental data on the ratio $R_b={\Gamma(Z\to b\bar{b})/\Gamma(Z\to hadrons)}$ are derived.Comment: Latex, 26 pages + 13 ps figures, final version in PR

Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major

Background The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in a wide range of pathogenic microorganisms. It has previously been demonstrated that small-molecule compounds designed to target Mip from the Gram-negative bacterium Burkholderia pseudomallei bind at the site of enzymatic activity of the protein, inhibiting the in vitro activity of Mip. Objectives In this study, co-crystallography experiments with recombinant B. pseudomallei Mip (BpMip) protein and Mip inhibitors, biochemical analysis and computational modelling were used to predict the efficacy of lead compounds for broad-spectrum activity against other pathogens. Methods Binding activity of three lead compounds targeting BpMip was verified using surface plasmon resonance spectroscopy. The determination of crystal structures of BpMip in complex with these compounds, together with molecular modelling and in vitro assays, was used to determine whether the compounds have broad-spectrum antimicrobial activity against pathogens. Results Of the three lead small-molecule compounds, two were effective in inhibiting the PPIase activity of Mip proteins from Neisseria meningitidis, Klebsiella pneumoniae and Leishmania major. The compounds also reduced the intracellular burden of these pathogens using in vitro cell infection assays. Conclusions These results indicate that Mip is a novel antivirulence target that can be inhibited using small-molecule compounds that prove to be promising broad-spectrum drug candidates in vitro. Further optimization of compounds is required for in vivo evaluation and future clinical applications

Star Formation and Dynamics in the Galactic Centre

The centre of our Galaxy is one of the most studied and yet enigmatic places in the Universe. At a distance of about 8 kpc from our Sun, the Galactic centre (GC) is the ideal environment to study the extreme processes that take place in the vicinity of a supermassive black hole (SMBH). Despite the hostile environment, several tens of early-type stars populate the central parsec of our Galaxy. A fraction of them lie in a thin ring with mild eccentricity and inner radius ~0.04 pc, while the S-stars, i.e. the ~30 stars closest to the SMBH (<0.04 pc), have randomly oriented and highly eccentric orbits. The formation of such early-type stars has been a puzzle for a long time: molecular clouds should be tidally disrupted by the SMBH before they can fragment into stars. We review the main scenarios proposed to explain the formation and the dynamical evolution of the early-type stars in the GC. In particular, we discuss the most popular in situ scenarios (accretion disc fragmentation and molecular cloud disruption) and migration scenarios (star cluster inspiral and Hills mechanism). We focus on the most pressing challenges that must be faced to shed light on the process of star formation in the vicinity of a SMBH.Comment: 68 pages, 35 figures; invited review chapter, to be published in expanded form in Haardt, F., Gorini, V., Moschella, U. and Treves, A., 'Astrophysical Black Holes'. Lecture Notes in Physics. Springer 201

TRY plant trait database – enhanced coverage and open access

Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits—almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Design Support and Tooling for Dependable Embedded Control Systems

The efficient design of resilient embedded systems is hampered by the separation of engineering disciplines in current development approaches. We describe a new project entitled “Design Support and Tooling for Embedded Control Software” (DESTECS), which aims to develop a methodology and open tools platform for collaborative and multidisciplinary development of dependable embedded real-time control systems. We also present some initial results from a small co-simulation case study. The DESTECS methodology combines continuous-time and discrete-event modelling via co-simulation, allowing explicit modelling of faults and fault-tolerance mechanisms from the outset. Continuous-time models are expressed using differential equations, which we represent using the wellknown bond graph notation, supported by the 20-sim tool. We model discrete-event controllers using the Vienna Development Method (VDM), supported by the Overture tools. An open, extensible tools platform will be developed, populated with plug-ins to support static analysis, co-simulation, testing and fault analysis. Trials will be conducted on industrial case studies from several domains, including document handling, inertial measurement and personal transportation