563 research outputs found
Adiabatic evolution on a spatial-photonic Ising machine
Combinatorial optimization problems are crucial for widespread applications
but remain difficult to solve on a large scale with conventional hardware.
Novel optical platforms, known as coherent or photonic Ising machines, are
attracting considerable attention as accelerators on optimization tasks
formulable as Ising models. Annealing is a well-known technique based on
adiabatic evolution for finding optimal solutions in classical and quantum
systems made by atoms, electrons, or photons. Although various Ising machines
employ annealing in some form, adiabatic computing on optical settings has been
only partially investigated. Here, we realize the adiabatic evolution of
frustrated Ising models with 100 spins programmed by spatial light modulation.
We use holographic and optical control to change the spin couplings
adiabatically, and exploit experimental noise to explore the energy landscape.
Annealing enhances the convergence to the Ising ground state and allows to find
the problem solution with probability close to unity. Our results demonstrate a
photonic scheme for combinatorial optimization in analogy with adiabatic
quantum algorithms and enforced by optical vector-matrix multiplications and
scalable photonic technology.Comment: 9 pages, 4 figure
Large-scale photonic Ising machine by spatial light modulation
Quantum and classical physics can be used for mathematical computations that
are hard to tackle by conventional electronics. Very recently, optical Ising
machines have been demonstrated for computing the minima of spin Hamiltonians,
paving the way to new ultra-fast hardware for machine learning. However, the
proposed systems are either tricky to scale or involve a limited number of
spins. We design and experimentally demonstrate a large-scale optical Ising
machine based on a simple setup with a spatial light modulator. By encoding the
spin variables in a binary phase modulation of the field, we show that light
propagation can be tailored to minimize an Ising Hamiltonian with spin
couplings set by input amplitude modulation and a feedback scheme. We realize
configurations with thousands of spins that settle in the ground state in a
low-temperature ferromagnetic-like phase with all-to-all and tunable pairwise
interactions. Our results open the route to classical and quantum photonic
Ising machines that exploit light spatial degrees of freedom for parallel
processing of a vast number of spins with programmable couplings.Comment: https://journals.aps.org/prl/accepted/7007eYb7N091546c41ad4108828a97d5f92006df
Immunodeficiency-associated viral oncogenesis
AbstractSeveral viruses with different replication mechanisms contribute to oncogenesis by both direct and indirect mechanisms in immunosuppressed subjects after solid organ transplantation, after allogeneic stem cell transplantation, or with human immunodeficiency virus (HIV) infection. Epstein–Barr virus (EBV), human papillomavirus (HPV), Kaposi sarcoma herpesvirus (KSHV), human T-cell lymphotropic virus type 1 (HTLV-1) and Merkel cell polyoma virus (MCV) are the main viruses associated with the development of cancer in immunosuppressed patients. Besides being a main cause of immunodeficiency, HIV1 has a direct pro-oncogenic effect. In this review, we provide an update on the association between the condition of acquired immunodeficiency and cancer risk, specifically addressing the contributions to oncogenesis of HPV, MCV, KSHV, HTLV-1, and EBV
Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report.
Abstract
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Introduction:
Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple reactive lymphoadenopathies and large intra-anal condylomas. The patient was treated with a complete excision of Bowen's lesion and with a 4 months course of supplementation with a high concentration multistrain probiotic formulation administered orally and by rectal instillation with the purpose to reduce local inflammation and to enhance local mucosal immunity.
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Conclusion:
An MRI performed at the end of the supplementation period evidenced the clearance of the anal condylomas previously described and no evidence of residual lymphadenopathies. Trials are therefore required to confirm this therapeutic possibility and for a better understanding of the mechanisms by which this specific probiotic formulation interacts with local epithelium when administered by the anal route
Observation of Fermi-Pasta-Ulam-Tsingou Recurrence and Its Exact Dynamics
One of the most controversial phenomena in nonlinear dynamics is the reappearance of initial
conditions. Celebrated as the Fermi-Pasta-Ulam-Tsingou problem, the attempt to understand how these
recurrences form during the complex evolution that leads to equilibrium has deeply influenced the entire
development of nonlinear science. The enigma is rendered even more intriguing by the fact that integrable
models predict recurrence as exact solutions, but the difficulties involved in upholding integrability for a
sufficiently long dynamic has not allowed a quantitative experimental validation. In natural processes,
coupling with the environment rapidly leads to thermalization, and finding nonlinear multimodal systems
presenting multiple returns is a long-standing open challenge. Here, we report the observation of more than
three Fermi-Pasta-Ulam-Tsingou recurrences for nonlinear optical spatial waves and demonstrate the
control of the recurrent behavior through the phase and amplitude of the initial field. The recurrence period
and phase shift are found to be in remarkable agreement with the exact recurrent solution of the nonlinear
Schrödinger equation, while the recurrent behavior disappears as integrability is lost. These results identify
the origin of the recurrence in the integrability of the underlying dynamics and allow us to achieve one of
the basic aspirations of nonlinear dynamics: the reconstruction, after several return cycles, of the exact
initial condition of the system, ultimately proving that the complex evolution can be accurately predicted in
experimental conditions
Facilitating the Decentralised Exchange of Cryptocurrencies in an Order-Driven Market
This article discusses a protocol to facilitate decentralised exchanges on an order-driven market through a consortium of market services operators. We discuss whether this hybrid protocol combining a centralised initiation phase with a decentralised execution phase outperforms fully centralised exchanges with regards to efficiency and security. Here, a fully efficient and fully secure protocol is defined as one where traders incur no trading costs or opportunity costs and counterparty risk is absent. We devise a protocol addressing the main downsides in the decentralised exchange process that uses a facilitating distributed ledger, maintains an order book and monitors the order status in real-time to provide accurate exchange rate information and performance scoring of participants. We show how performance ratings can lower opportunity costs and how a rolling benchmark rate of verifiable trades can be used to establish a trustworthy exchange rate between cryptocurrencies. The formal validation of the proposed technical mechanisms is the subject of future work
Early and late follow-up of untreated traumatic aortic lesion: a support to delayed surgery
Fuente Fuente, Carlos;Montes Gil, Antonio;Periel Piquer, Montserra
Topological control of extreme waves
From optics to hydrodynamics, shock and rogue waves are widespread. Although they appear as distinct phenomena, transitions between extreme waves are allowed. However, these have never been experimentally observed because control strategies are still missing. We introduce the new concept of topological control based on the one-to-one correspondence between the number of wave packet oscillating phases and the genus of toroidal surfaces associated with the nonlinear Schrödinger equation solutions through Riemann theta functions. We demonstrate the concept experimentally by reporting observations of supervised transitions between waves with different genera. Considering the box problem in a focusing photorefractive medium, we tailor the time-dependent nonlinearity and dispersion to explore each region in the state diagram of the nonlinear wave propagation. Our result is the first realization of topological control of nonlinear waves. This new technique casts light on shock and rogue waves generation and can be extended to other nonlinear phenomena
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