Persistent Homology Analysis of Brain Artery Trees.

New representations of tree-structured data objects, using ideas from topological data analysis, enable improved statistical analyses of a population of brain artery trees. A number of representations of each data tree arise from persistence diagrams that quantify branching and looping of vessels at multiple scales. Novel approaches to the statistical analysis, through various summaries of the persistence diagrams, lead to heightened correlations with covariates such as age and sex, relative to earlier analyses of this data set. The correlation with age continues to be significant even after controlling for correlations from earlier significant summaries

Body mass index and outcome in renal transplant recipients: a systematic review and meta-analysis

BACKGROUND: Whether overweight or obese end stage renal disease (ESRD) patients are suitable for renal transplantation (RT) is often debated. The objective of this review and meta-analysis was to systematically investigate the outcome of low versus high BMI recipients after RT. METHODS: Comprehensive searches were conducted in MEDLINE OvidSP, Web of Science, Google Scholar, Embase, and CENTRAL (the Cochrane Library 2014, issue 8). We reviewed four major guidelines that are available regarding (potential) RT recipients. The methodology was in accordance with the Cochrane Handbook for Systematic Reviews of Interventions and written based on the PRISMA statement. The quality assessment of studies was performed by using the GRADE tool. A meta-analysis was performed using Review Manager 5.3. Random-effects models were used. RESULTS: After identifying 5,526 studies addressing this topic, 56 studies were included. We extracted data for 37 outcome measures (including data of more than 209,000 RT recipients), of which 26 could be meta-analysed. The following outcome measures demonstrated significant differences in favour of low BMI (<30) recipients: mortality (RR = 1.52), delayed graft function (RR = 1.52), acute rejection (RR = 1.17), 1-, 2-, and 3-year graft survival (RR = 0.97, 0.95, and 0.97), 1-, 2-, and 3-year patient survival (RR = 0.99, 0.99, and 0.99), wound infection and dehiscence (RR = 3.13 and 4.85), NODAT (RR = 2.24), length of hospital stay (2.31 days), operation duration (0.77 hours), hypertension (RR = 1.35), and incisional hernia (RR = 2.72). However, patient survival expressed in hazard ratios was in significant favour of high BMI recipients. Differences in other outcome parameters were not significant. CONCLUSIONS: Several of the pooled outcome measurements show significant benefits for ‘low’ BMI (<30) recipients. Therefore, we postulate that ESRD patients with a BMI >30 preferably should lose weight prior to RT. If this cannot be achieved with common measures, in morbidly obese RT candidates, bariatric surgery could be considered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12916-015-0340-5) contains supplementary material, which is available to authorized users

Pay to play: Children’s emerging ability to use acts of generosity for selfish ends

Adults will offer favors to advance their standing and solicit a favor in return, using ostensibly prosocial acts strategically for selfish ends. Here we assessed the developmental emergence of such strategic behaviors in which individuals are generous to elicit future reciprocation from others. In a novel experimental paradigm with children aged 3 to 7 years, we tested whether children are willing to share more valuable resources when this act could prompt subsequent reciprocation. In an Experimental condition, children could share a more attractive or less attractive resource with a person who they knew would subsequently choose to play a game with either the children or another individual. In the Control condition, children knew the person would play alone. Across two studies, we found that over repeated trials, 5- and 7-year-olds, but not 3-year-olds, learned to share more valuable resources in the Experimental condition than in the Control condition. This shows that older age groups were able to quickly learn how to influence the subsequent partner choice in a novel situation. We address theoretical questions about the various types of reciprocity as being supported by different psychological mechanisms and discuss whether the current results could be explained by children’s emerging ability for future-directed thinking.Depto. de Investigación y Psicología en EducaciónFac. de PsicologíaTRUEpu

Australian not by blood, but by character: soldiers and refugees in Australian children's picture books

In recent years, Australian children’s picture books dealing with the First World War have balanced the increasingly sentimentalized construct of the Australian soldier as a victim of trauma and the traditional use of Australian war literature as a means of exploring national identity. It is an approach that has proved quite malleable, for variations of it have been used in children’s picture books dealing with the far more polemic issue of refugees. By drawing on this framework authors and illustrators position refugees as victims of trauma who have displayed qualities that are entirely consistent with a construct of national identity grounded in martial achievement. Readers of these texts are encouraged to welcome these arrivals at a literal level as new citizens and symbolically as new inductees into a pervasive construct of national identity

Understanding the mental health of refugees: Trauma, stress, and the cultural context

At the end of 2016, there were a record-high 65.6 million people forcibly displaced according to the United Nations High Commissioner for Refugees (1). With 300,000 new people displaced in 2016, there were 20 people newly displaced every minute of 2016. Most refugees flee their homes with little time to prepare (2) and, in turn, frequently are ill-equipped with the financial, linguistic, and other resources needed to address the challenges of the journey that lies ahead. The nature of the pre-migration and flight experiences for refugees, which are frequently marked by fear, forced departure, and experiences of torture and trauma, distinguishes them from other voluntary migrants. Since 1975 approximately three million individuals have been resettled in the USA (approximately 2 million adults and 1 million children) (3); this represents a significant population to respond to clinically. Importantly, status as a forcibly displaced person seeking refuge is not in itself a psychiatric condition – refugee status is a sociopolitical phenomenon with common downstream psychosocial effects (4). As refugees resettle in third party countries, often after prolonged stays in refugee camps in a country or countries outside of their home, many experience mental health problems associated with past trauma, ongoing stress, or both. In order to effectively serve resettled refugee and migrant communities, mental health professionals including, researchers, clinicians, educators, and policy makers need to understand the impact of the refugee experience and cultural contexts on psychosocial functioning. This chapter will review the unique mental health challenges and culturally-responsive assessments and treatments targeting some of the world’s most vulnerable and resilient populations